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Journal of Cardiovascular Translational Research
Erschienen in:

29.07.2024 | Review

The Role of Methylation in Ferroptosis

verfasst von: Yushu Xie, Jie Xie, Liang Li

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 6/2024

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Abstract

Methylation modification is a crucial epigenetic alteration encompassing RNA methylation, DNA methylation, and histone methylation. Ferroptosis represents a newly discovered form of programmed cell death (PCD) in 2012, which is characterized by iron-dependent lipid peroxidation. The comprehensive investigation of ferroptosis is therefore imperative for a more profound comprehension of the pathological and pathophysiological mechanisms implicated in a wide array of diseases. Researches show that methylation modifications can exert either promotive or inhibitory effects on cell ferroptosis. Consequently, this review offers a comprehensive overview of the pivotal role played by methylation in ferroptosis, elucidating its associated factors and underlying mechanisms.
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Metadaten
Titel
The Role of Methylation in Ferroptosis
verfasst von
Yushu Xie
Jie Xie
Liang Li
Publikationsdatum
29.07.2024
Verlag
Springer US
Erschienen in
Journal of Cardiovascular Translational Research / Ausgabe 6/2024
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-024-10539-1

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Silencing DOCK2 Attenuates Cardiac Fibrosis Following Myocardial Infarction in Mice Via Targeting PI3K/Akt and Wnt/β-Catenin Pathways

  • Original Article

A Kernel Attention-based Transformer Model for Survival Prediction of Heart Disease Patients

  • Original Article

Cirbp: A Key Regulator in Hypothermic Cardioprotection of Aged Donor Hearts During Transplantation

  • Editorial

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Schützen GLP1-Rezeptor-Agonisten vor kardiovaskulären Komplikationen nach Pneumonie?

Kardiovaskuläre Ereignisse nach Lungeninfektionen sind häufig, doch pathophysiologisch wenig verstanden. Dass womöglich Glukagon daran Anteil hat, eröffnet neue therapeutische Perspektiven.

Beeinträchtigte Ventrikelfüllung erhöht die COPD-Mortalität

  • 24.04.2025
  • COPD
  • Nachrichten

Patienten mit chronisch obstruktiver Lungenerkrankung und eingeschränkter Füllung der linken Herzkammer haben ein erhöhtes Sterberisiko. Dabei sind zwei Formen des Füllungsdefizits zu unterscheiden, wie eine Studie zeigt.

Auf dem Weg zur Präzisionsmedizin in der Kardiologie

Eine Entwicklung hin zur Präzisionsmedizin ist derzeit auch im Bereich der Kardiologie voll im Gang. Informationen zu den dabei inzwischen erzielten Fortschritten gab es bei der DGK-Jahrestagung 2025 in Mannheim.

Nach kardiovaskulärer Erkrankung steigt das Krebsrisiko

Wer an einer kardiovaskulären Erkrankung (CVD) leidet, hat offenbar ein erhöhtes Risiko, in der Folge auch noch eine Krebsdiagnose zu erhalten. Der Zusammenhang scheint für diverse CVD und Krebsentitäten zu gelten.

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

In diesem CME-Kurs können Sie Ihr Wissen zur EKG-Befundung anhand von zwölf Video-Tutorials auffrischen und 10 CME-Punkte sammeln.
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