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Journal of Gastroenterology
Erschienen in: Journal of Gastroenterology 6/2016

21.01.2016 | Review

The role of microRNA in esophageal squamous cell carcinoma

verfasst von: Kazuto Harada, Yoshifumi Baba, Takatsugu Ishimoto, Hironobu Shigaki, Keisuke Kosumi, Naoya Yoshida, Masayuki Watanabe, Hideo Baba

Erschienen in: Journal of Gastroenterology | Ausgabe 6/2016

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Abstract

MicroRNAs (miRNA) are 22-nucleotide non-coding RNAs that post-transcriptionally regulate gene expression by base pairing to partially complementary sequences in the 3′-untranslated region of their target messenger RNA. Altered miRNA expression also changes the expression of oncogenes and tumor suppressors, affecting the proliferation, apoptosis, motility and invasibility of gastrointestinal cancer cells, including the cells of esophageal squamous cell carcinoma (ESCC). It has been suggested that various miRNA expression profiles may provide useful biomarkers and therapeutic targets, but to date few studies have been published on the role of miRNA in ESCC. In this review we summarize the identification and characterization of miRNAs involved in ESCC and discuss their potential as biomarkers and therapeutic targets.
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Metadaten
Titel
The role of microRNA in esophageal squamous cell carcinoma
verfasst von
Kazuto Harada
Yoshifumi Baba
Takatsugu Ishimoto
Hironobu Shigaki
Keisuke Kosumi
Naoya Yoshida
Masayuki Watanabe
Hideo Baba
Publikationsdatum
21.01.2016
Verlag
Springer Japan
Erschienen in
Journal of Gastroenterology / Ausgabe 6/2016
Print ISSN: 0944-1174
Elektronische ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-016-1161-9

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