Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Current Cardiovascular Imaging Reports
Erschienen in: Current Cardiovascular Imaging Reports 7/2017

01.07.2017 | Cardiac Nuclear Imaging (A Cuocolo and M Petretta, Section Editors)

The Role of Nuclear Cardiac Imaging in Infective Endocarditis

verfasst von: Martina Sollini, Roberto Boni, Lidija Antunovic, Margarita Kirienko, Elena Lazzeri, Paola Anna Erba

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 7/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Infective endocarditis (IE) remains a deadly disease despite improvements in its management. Echocardiography is crucial for the diagnosis of IE; however, its value is operator-dependent and its sensitivity can decrease in the presence of valvular prosthesis. This review aims to provide an overview on the role of nuclear cardiac imaging in the diagnosis of IE.

Recent Findings

Among all nuclear cardiac imaging modalities, both radiolabeled leukocyte scintigraphy and 2-deoxy-2-[fluorine-18]fluoro-D-glucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) have been recently introduced in the guidelines of European Society of Cardiology (ESC) for the management of IE. The ESC guidelines included some minor criteria (mainly clinical), and two different sets of major criteria based on blood culture and imaging, respectively. The positivity of either radiolabeled leukocyte scintigraphy or [18F]FDG-PET/CT images is considered itself a major criterion to diagnose IE. However, nuclear cardiac imaging analysis may be tricky and methodological and technical aspects should be carefully considered.

Summary

Available evidence supports the role of nuclear cardiac imaging in the diagnosis and management of IE. However, all practitioners who act within the “Endocarditis Team” should present a very high level of expertise.
Literatur
1.
Murdoch DR, Corey GR, Hoen B, Miró JM, Fowler VG, Bayer AS, et al. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the international collaboration on endocarditis-prospective cohort study. Arch Intern Med. 2009;169:463–73.CrossRefPubMedPubMedCentral
2.
Vogkou C, Vlachogiannis N, Palaiodimos L, Kousoulis A. The causative agents in infective endocarditis: a systematic review comprising 33,214 cases. Eur J Clin Microbiol Infect Dis. 2016;35:1227–45.CrossRefPubMed
3.
Thuny F, Hubert S, Tribouilloy C, Le Dolley Y, Casalta JP, Riberi A, et al. Sudden death in patients with infective endocarditis: findings from a large cohort study. Int J Cardiol. 2013;162:129–32.CrossRefPubMed
4.
Htwe TH, Khardori NM. Cardiac emergencies: infective endocarditis, pericarditis, and myocarditis. Med Clin North Am. 2012;96:1149–69.CrossRefPubMed
5.
Durante-Mangoni E, Bradley S, Selton-Suty C, Tripodi M-F, Barsic B, Bouza E, et al. Current features of infective endocarditis in elderly patients: results of the international collaboration on endocarditis prospective cohort study. Arch Intern Med. 2008;168:2095–103.CrossRefPubMed
6.
Osler W. The Gulstonian lectures , on malignant endocarditis. Br Med J. 1885;1:1885.CrossRef
7.
Durack DT, Lukes ASBD. New criteria for diagnosis of infective endocarditis: utilization of specific endocardiographic findings. Am J Med. 1994;96:200–9.CrossRefPubMed
8.
Habib G, Derumeaux G, Avierinos JF, Casalta JP, Jamal F, Volot F, et al. Value and limitations of the duke criteria for the diagnosis of infective endocarditis. J Am Coll Cardiol. 1999;33:2023–9.CrossRefPubMed
9.
Li JS, Sexton DJ, Mick N, Nettles R, Fowler VG, Ryan T, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000;30:633–8.CrossRefPubMed
10.
• Erba PA, Conti U, Lazzeri E, Sollini M, Doria R, De Tommasi SM, et al. Added value of 99mTc-HMPAO-labeled leukocyte SPECT/CT in the characterization and management of patients with infectious endocarditis. J Nucl Med. 2012;53:1235–43. This is the first paper reporting the added value of 99m Tc-HMPAO-labeled leukocyte SPECT/CT in a large series of patients with infectiosu endcarditis. CrossRefPubMed
11.
•• Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta J-P, Del Zotti F, et al. 2015 ESC guidelines for the management of infective endocarditis. Eur Heart J. 36:ehv319. These are the first clinical guidelines which included nuclear medicine imaging in the diagnostic alghorithm of infective endocarditis and defined the “Endocarditis Team”.
12.
Iung B, Erba PA, Petrosillo N, Lazzeri E. Common diagnostic flowcharts in infective endocarditis. Q J Nucl Med Mol imaging Off Publ Ital Assoc Nucl Med [and] Int Assoc Radiopharmacol (IAR), [and] Sect Soc Radiopharm. 2014;58:55–65.
13.
Erba PA, Sollini M, Boni R, Lazzeri E. Other imaging modalities in infective endocarditis diagnosis. In: Habib G, editor. Infect. Endocarditis Epidemiol. Diagnosis, imaging, Ther. Prev. 1st ed. Heidelberg: Springer-Verlag Berlin; 2016. p. 51–80.CrossRef
14.
Caobelli F, Wollenweber T, Bavendiek U, Kühn C, Schütze C, Geworski L, et al. Simultaneous dual-isotope solid-state detector SPECT for improved tracking of white blood cells in suspected endocarditis. Eur. Heart J. 2016;ehw231.
15.
Glaudemans AWJM, de Vries EFJ, Vermeulen LEM, Slart RHJA, Dierckx RAJO, Signore A. A large retrospective single-centre study to define the best image acquisition protocols and interpretation criteria for white blood cell scintigraphy with 99mTc-HMPAO-labelled leucocytes in musculoskeletal infections. Eur J Nucl Med Mol Imaging. 2013;40:1760–9.CrossRefPubMed
16.
Lazzeri E, Israel O, Erba P, Chakravartty R, Comin J, Jamar F, et al. Comment on Aksoy et al.: FDG and FDG-labelled leucocyte PET/CT in the imaging of prosthetic joint infection. Eur J Nucl Med Mol Imaging. 2014;41:1811–2.CrossRefPubMed
17.
Hyafil F, Rouzet F, Lepage L, Benali K, Raffoul R, Duval X, et al. Role of radiolabelled leucocyte scintigraphy in patients with a suspicion of prosthetic valve endocarditis and inconclusive echocardiography. Eur. Heart J. Cardiovasc. Imaging. 2013;14:586–94.CrossRefPubMed
18.
Hyafil F, Rouzet F, Le Guludec D. Nuclear imaging for patients with a suspicion of infective endocarditis: be part of the team! J Nucl Cardiol. 2015:1–5.
19.
Thurlow LR, Thomas VC, Narayanan S, Olson S, Fleming SD, Hancock LE. Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis. Infect Immun. 2010;78:4936–43.CrossRefPubMedPubMedCentral
20.
Cheung GYC, Rigby K, Wang R, Queck SY, Braughton KR, Whitney AR, et al. Staphylococcus epidermidis strategies to avoid killing by human neutrophils. PLoS Pathog. 2010;6:15–6.CrossRef
21.
•• Saby L, Laas O, Habib G, Cammilleri S, Mancini J, Tessonnier L, et al. Positron emission tomography/computed tomography for diagnosis of prosthetic valve endocarditis: increased valvular 18F-fluorodeoxyglucose uptake as a novel major criterion. J Am Coll Cardiol. 2013;61:2374–82. This is the first paper that proposed the introduction of increased valvular [ 18 F]FDG uptake as a novel major criteria in prosthetic valve endocarditis.
22.
•• Erba PA, Sollini M, Lazzeri E, Mariani G. FDG-PET in cardiac infections. Semin Nucl Med. 2013;43:377–95. This paper summarizes published evidence on the usefulness of [ 18 F]FDG-PET for the diagnosis of cardiac infections.
23.
Yan J, Zhang C, Niu Y, Yuan R, Zeng X, Ge X, et al. The role of 18F-FDG PET/CT in infectious endocarditis: a systematic review and meta- analysis. Int J Clin Pharmacol Ther. 2016;54:337–42.CrossRefPubMed
24.
Ahmed FZ, James J, Memmott MJ, Arumugam P. Radionuclide imaging of cardiovascular infection. Cardiol Clin. 2016;34:149–65.CrossRefPubMed
25.
26.
Chen W, Kim J, Molchanova-Cook OP, Dilsizian V. The potential of FDG PET/CT for early diagnosis of cardiac device and prosthetic valve infection before morphologic damages ensue. Curr Cardiol Rep. 2014;16:459.CrossRefPubMed
27.
Jenkins WSA, Chin C, Rudd JHF, Newby DE, Dweck MR. What can we learn about valvular heart disease from PET/CT? Futur Cardiol. 2013;9:657–67.CrossRef
28.
Balmforth D, Chacko J, Uppal R. Does positron emission tomography/computed tomography aid the diagnosis of prosthetic valve infective endocarditis? Interact. Cardiovasc. Thorac. Surg. 2016;ivw177.
29.
•• Tanis W, Budde RPJ, Van Der Bilt IAC, Delemarre B, Hoohenker G, Van Rooden JK, et al. Novel imaging strategies for the detection of prosthetic heart valve obstruction and endocarditis. Netherlands Hear J. 2016;24:96–107. This paper reviews the role of novel imaging tools in the field of prosthetic heart valve obstruction and endocarditis.
30.
Orvin K, Goldberg E, Bernstine H, Groshar D, Sagie A, Kornowski R, et al. The role of FDG-PET/CT imaging in early detection of extra-cardiac complications of infective endocarditis. Clin Microbiol Infect. 2015;21:69–76.CrossRefPubMed
31.
Ricciardi A, Sordillo P, Ceccarelli L, Maffongelli G, Calisti G, Di Pietro B, et al. 18-Fluoro-2-deoxyglucose positron emission tomography-computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis. Int J Infect Dis. 2014;28:219–24.CrossRefPubMed
32.
Kestler M, Muñoz P, Rodríguez-Créixems M, Rotger A, Jimenez-Requena F, Mari A, et al. Role of 18F-FDG PET in patients with infectious endocarditis. J Nucl Med. 2014;55:1093–8.CrossRefPubMed
33.
Kouijzer IJE, Vos FJ, Janssen MJR, van Dijk APJ, Oyen WJG, Bleeker-Rovers CP. The value of 18F-FDG PET/CT in diagnosing infectious endocarditis. Eur J Nucl Med Mol Imaging. 2013;40:1102–7.CrossRefPubMed
34.
Asmar A, Ozcan C, Diederichsen ACP, Thomassen A, Gill S. Clinical impact of 18F-FDG-PET/CT in the extra cardiac work-up of patients with infective endocarditis. Eur Heart J Cardiovasc Imaging. 2014;15:1013–9.CrossRefPubMed
35.
Salomäki SP, Saraste A, Kemppainen J, Bax JJ, Knuuti J, Nuutila P, et al. 18F-FDG positron emission tomography/computed tomography in infective endocarditis. J Nucl Cardiol. 2015:1–12.
36.
•• Gomes A, Glaudemans AWJM, Touw DJ, van Melle JP, Willems TP, Maass AH, et al. Diagnostic value of imaging in infective endocarditis: a systematic review. Lancet Infect Dis. 2016;3099:16–7. This systematic review found positive albeit weak evidence for the diagnostic benefit of [ 18 F]FDG PET/CT and MDCTA.
37.
Pizzi MN, Roque A, Fernández-Hidalgo N, Cuéllar-Calabria H, Ferreira-González I, Gonzàlez-Alujas MT, et al. Improving the diagnosis of infective endocarditis in prosthetic valves and intracardiac devices with 18F-fluordeoxyglucose positron emission tomography/computed tomography angiography: initial results at an infective endocarditis referral center. Circulation. 2015;132:1113–26.CrossRefPubMed
38.
Granados U, Fuster D, Pericas JM, Llopis J, Ninot S, Quintana E, et al. Diagnostic accuracy of 18F-FDG PET/CT in infective endocarditis and implantable cardiac electronic device infection: a cross-sectional study. J Nucl Med. 2016:15–6.
39.
Fagman E, van Essen M, Fredén Lindqvist J, Snygg-Martin U, Bech-Hanssen O, Svensson G. 18F–FDG PET/CT in the diagnosis of prosthetic valve endocarditis. Int. J. Cardiovasc. Imaging. 2015;679–86.
40.
de Groot M, Meeuwis APW, Kok PJM, Corstens FHM, Oyen WJG. Influence of blood glucose level, age and fasting period on non-pathological FDG uptake in heart and gut. Eur J Nucl Med Mol Imaging. 2005;32:98–101.CrossRefPubMed
41.
Dorbala S, Di Carli MF, Delbeke D, Abbara S, DePuey EG, Dilsizian V, et al. SNMMI/ASNC/SCCT guideline for cardiac SPECT/CT and PET/CT 1.0. J Nucl Med. 2013;54:1485–507.CrossRefPubMed
42.
Osborne MT, Hulten EA, Murthy VL, Skali H, Taqueti VR, Dorbala S, et al. Patient preparation for cardiac fluorine-18 fluorodeoxyglucose positron emission tomography imaging of inflammation. J Nucl Cardiol. 2017;24:86–99.CrossRefPubMed
43.
Fan C-M, Fischman AJ, Kwek BH, Abbara S, Aquino SL. Lipomatous hypertrophy of the interatrial septum: increased uptake on FDG PET. AJR Am J Roentgenol. 2005;184:339–42.CrossRefPubMed
44.
Scholtens AM, Swart LE, Verberne HJ, Tanis W, Lam MGEH, Budde RPJ. Confounders in FDG-PET/CT imaging of suspected prosthetic valve endocarditis. JACC Cardiovasc. Imaging. 2016;27344422.
45.
Buteau JP, Morais J, Keu KV. 18F–FDG PET/CT uptake of a nonbacterial thrombotic endocarditis. J. Nucl. Cardiol. 2016;27000880.
46.
Rouzet F, Chequer R, Benali K, Lepage L, Ghodbane W, Duval X, et al. Respective performance of 18F-FDG PET and radiolabeled leukocyte scintigraphy for the diagnosis of prosthetic valve endocarditis. J Nucl Med. 2014;55:1980–5.CrossRefPubMed
47.
Pizzi MN, Roque A, Cuéllar-Calabria H, Fernández-Hidalgo N, Ferreira-González I, González-Alujas MT, et al. 18F-FDG-PET/CTA of prosthetic cardiac valves and valve-tube grafts. JACC Cardiovasc Imaging. 2016;9:9–12.CrossRef
48.
Scholtens AM, van Aarnhem EEHL, Budde RP. Effect of antibiotics on FDG-PET/CT imaging of prosthetic heart valve endocarditis. Eur Hear J – Cardiovasc Imaging. 2015;16:1223.CrossRef
49.
Yilmaz S, Aliyev A, Ekmekcioglu O, Ozhan M, Uslu L, Vatankulu B, et al. Comparison of FDG and FDG-labeled leukocytes PET/CT in diagnosis of infection. Nuklearmedizin. 2015;54:262–71.CrossRefPubMed
Metadaten
Titel
The Role of Nuclear Cardiac Imaging in Infective Endocarditis
verfasst von
Martina Sollini
Roberto Boni
Lidija Antunovic
Margarita Kirienko
Elena Lazzeri
Paola Anna Erba
Publikationsdatum
01.07.2017
Verlag
Springer US
Erschienen in
Current Cardiovascular Imaging Reports / Ausgabe 7/2017
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-017-9421-5

Neu im Fachgebiet Kardiologie

25.04.2024 | Hypotonie | Nachrichten

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 | Hypertonie | Nachrichten

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

24.04.2024 | Adipositas | Nachrichten

Adipositas-Medikament auch gegen Schlafapnoe wirksam

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Myokarditis nach Infekt – Richtig schwierig wird es bei Profisportlern
weitere anzeigen

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen