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05.07.2018 | Neurological Disease and Cognitive Function (Y Gu, Section Editor) | Ausgabe 3/2018

The Role of Nutrition in Cognitive Function and Brain Ageing in the Elderly

Zeitschrift:: Current Nutrition Reports > Ausgabe 3/2018

Autoren:: Samantha L. Gardener, Stephanie R. Rainey-Smith

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Wichtige Hinweise

This article is part of the Topical Collection on Neurological Disease and Cognitive Function

Abstract

Purpose of Review

The purposes of this review were to examine literature published over the last 5 years and to evaluate the role of nutrition in cognitive function and brain ageing, focussing on the Mediterranean diet (MeDi), Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets.

Recent Findings

Results suggest that higher adherence to a healthy dietary pattern is associated with preservation of brain structure and function as well as slower cognitive decline, with the MIND diet substantially slowing cognitive decline, over and above the MeDi and DASH diets.

Summary

Whilst results to-date suggest adherence to a healthy diet, such as the MeDi, DASH, or MIND, is an important modifiable risk factor in the quest to develop strategies aimed at increasing likelihood of healthy brain ageing, further work is required to develop dietary guidelines with the greatest potential benefit for public health; a research topic of increasing importance as the world’s population ages.

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Tucker-Drob EM, Reynolds CA, Finkel D, Pedersen NL. Shared and unique genetic and environmental influences on aging-related changes in multiple cognitive abilities. Dev Psychol. 2014;50(1):152–66. CrossRefPubMed

Cover KS, van Schijndel RA, van Dijk BW, Redolfi A, Knol DL, Frisoni GB, et al. Assessing the reproducibility of the SienaX and Siena brain atrophy measures using the ADNI back-to-back MP-RAGE MRI scans. Psychiatry Res. 2011;193(3):182–90. CrossRefPubMed

Raz N, Lindenberger U, Rodrigue KM, Kennedy KM, Head D, Williamson A, et al. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb Cortex. 2005;15(11):1676–89. CrossRefPubMed

Jobst KA, Smith AD, Szatmari M, Molyneux A, Esiri ME, King E, et al. Detection in life of confirmed Alzheimer's disease using a simple measurement of medial temporal lobe atrophy by computed tomography. Lancet. 1992;340(8829):1179–83. CrossRefPubMed

Berti V, Mosconi L, Pupi A. Brain: normal variations and benign findings in fluorodeoxyglucose-PET/computed tomography imaging. PET Clin. 2014;9(2):129–40. CrossRefPubMed

Salmon E, Sadzot B, Maquet P, Degueldre C, Lemaire C, Rigo P, et al. Differential diagnosis of Alzheimer’s disease with PET. J Nucl Med. 1994;35(3):391–8. PubMed

Rowe CC, Villemagne VL. Brain amyloid imaging. J Nucl Med. 2011;52(11):1733–40. PubMed

Zheng H, Koo EH. Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener. 2011;6(1):27. CrossRefPubMedPubMedCentral

Gao X, Chen H, Fung TT, Logroscino G, Schwarzschild MA, Hu FB, et al. Prospective study of dietary pattern and risk of Parkinson disease. Am J Clin Nutr. 2007;86(5):1486–94. CrossRefPubMedPubMedCentral

10.

Scarmeas N, Luchsinger JA, Mayeux R, Stern Y. Mediterranean diet and Alzheimer disease mortality. Neurology. 2007;69(11):1084–93. CrossRefPubMedPubMedCentral

11.

Scarmeas N, Stern Y, Mayeux R, Luchsinger JA. Mediterranean diet, Alzheimer disease, and vascular mediation. Arch Neurol. 2006;63(12):1709–17. CrossRefPubMedPubMedCentral

12.

Scarmeas N, Stern Y, Mayeux R, Manly JJ, Schupf N, Luchsinger JA. Mediterranean diet and mild cognitive impairment. Arch Neurol. 2009;66(2):216–25. CrossRefPubMedPubMedCentral

13.

Scarmeas N, Stern Y, Tang MX, Mayeux R, Luchsinger JA. Mediterranean diet and risk for Alzheimer’s disease. Ann Neurol. 2006;59(6):912–21. CrossRefPubMedPubMedCentral

14.

Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med. 2003;348(26):2599–608. CrossRefPubMed

15.

Sofi F, Abbate R, Gensini GF, Casini A. Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am J Clin Nutr. 2010;92(5):1189–96. CrossRefPubMed

16.

Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Adherence to Mediterranean diet and health status: meta-analysis. BMJ. 2008;337:a1344. CrossRefPubMedPubMedCentral

17.

Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997;336(16):1117–24. CrossRefPubMed

18.

• Morris MC, Tangney CC, Wang Y, Sacks FM, Barnes LL, Bennett DA, et al. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015;11(9):1015–22. This study examined all three dietary patterns investigated in this review, and concluded that low MIND diet adherence is more predictive of cognitive decline than either low MeDi or DASH diet scores. CrossRefPubMedPubMedCentral

19.

Kesse-Guyot E, Andreeva VA, Lassale C, Ferry M, Jeandel C, Hercberg S, et al. Mediterranean diet and cognitive function: a French study. Am J Clin Nutr. 2013;97(2):369–76. CrossRefPubMed

20.

Samieri C, Sun Q, Townsend MK, Chiuve SE, Okereke OI, Willett WC, et al. The association between dietary patterns at midlife and health in aging: an observational study. Ann Intern Med. 2013;159(9):584–91. CrossRefPubMedPubMedCentral

21.

Samieri C, Okereke OI, E ED, Grodstein F. Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in women. J Nutr. 2013;143(4):493–9. CrossRefPubMedPubMedCentral

22.

Katsiardanis K, Diamantaras AA, Dessypris N, Michelakos T, Anastasiou A, Katsiardani KP, et al. Cognitive impairment and dietary habits among elders: the Velestino study. J Med Food. 2013;16(4):343–50. CrossRefPubMed

23.

Martinez-Lapiscina EH, Clavero P, Toledo E, Estruch R, Salas-Salvado J, San Julian B, et al. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry. 2013;84(12):1318–25. CrossRefPubMed

24.

Martinez-Lapiscina EH, Clavero P, Toledo E, San Julian B, Sanchez-Tainta A, Corella D, et al. Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial. J Nutr Health Aging. 2013;17(6):544–52. CrossRefPubMed

25.

Tsivgoulis G, Judd S, Letter AJ, Alexandrov AV, Howard G, Nahab F, et al. Adherence to a Mediterranean diet and risk of incident cognitive impairment. Neurology. 2013;80(18):1684–92. CrossRefPubMedPubMedCentral

26.

Tangney CC, Li H, Wang Y, Barnes L, Schneider JA, Bennett DA, et al. Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons. Neurology. 2014;83(16):1410–6. CrossRefPubMedPubMedCentral

27.

Gardener SL, Rainey-Smith SR, Barnes MB, Sohrabi HR, Weinborn M, Lim YY, et al. Dietary patterns and cognitive decline in an Australian study of ageing. Mol Psychiatry. 2014;

28.

•• Valls-Pedret C, Sala-Vila A, Serra-Mir M, Corella D, de la Torre R, Martinez-Gonzalez MA, et al. Mediterranean diet and age-related cognitive decline: a randomized clinical trial. JAMA Int Med. 2015;175(7):1094–103. This is the first MeDi intervention trial, with analysis of cognitive performance both pre- and post- intervention, demonstrating a positive effect of MeDi consumption, supplemented with both nuts and extra virgin olive oil, on cognition. Intervention trials are required to establish a causal relationship between diet and cognitive performance. CrossRef

29.

McEvoy CT, Guyer H, Langa KM, Yaffe K. Neuroprotective diets are associated with better cognitive function: the health and retirement study. J Am Geriatr Soc. 2017;65(8):1857–62. CrossRefPubMedPubMedCentral

30.

Mosconi L, Murray J, Tsui WH, Li Y, Davies M, Williams S, et al. Mediterranean diet and magnetic resonance imaging-assessed brain atrophy in cognitively normal individuals at risk for Alzheimer’s disease. J Prev Alzheimers Dis. 2014;1(1):23–32. PubMedPubMedCentral

31.

Gu Y, Brickman AM, Stern Y, Habeck CG, Razlighi QR, Luchsinger JA, et al. Mediterranean diet and brain structure in a multiethnic elderly cohort. Neurology. 2015;85(20):1744–51. CrossRefPubMedPubMedCentral

32.

Staubo SC, Aakre JA, Vemuri P, Syrjanen JA, Mielke MM, Geda YE, et al. Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2017;13(2):168–77. CrossRef

33.

Titova OE, Ax E, Brooks SJ, Sjogren P, Cederholm T, Kilander L, et al. Mediterranean diet habits in older individuals: associations with cognitive functioning and brain volumes. Exp Gerontol. 2013;48(12):1443–8. CrossRefPubMed

34.

Pelletier A, Barul C, Feart C, Helmer C, Bernard C, Periot O, et al. Mediterranean diet and preserved brain structural connectivity in older subjects. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2015;11(9):1023–31. CrossRef

35.

• Gu Y, Scarmeas N, Stern Y, Manly J, Schupf N, Mayeux R, et al. Mediterranean diet is associated with slower rates of hippocampal atrophy: a longitudinal study in cognitively normal older adults. Alzheimers Dement. 2016;12(7):193–4. One of the few longitudinal studies investigating MeDi adherence and brain atrophy in a relatively large cohort of cognitively normal participants. Higher MeDi adherence was associated with slower rate of hippocampal atrophy. CrossRef

36.

Luciano M, Corley J, Cox SR, Valdes Hernandez MC, Craig LC, Dickie DA, et al. Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort. Neurology. 2017;88(5):449–55. CrossRefPubMedPubMedCentral

37.

Matthews DC, Davies M, Murray J, Williams S, Tsui WH, Li Y, et al. Physical activity, Mediterranean diet and biomarkers-assessed risk of Alzheimer’s: a multi-modality brain imaging study. Adv J Mol Imaging. 2014;4(4):43–57. CrossRefPubMedPubMedCentral

38.

Merrill DA, Siddarth P, Raji CA, Emerson ND, Rueda F, Ercoli LM, et al. Modifiable risk factors and brain positron emission tomography measures of amyloid and tau in nondemented adults with memory complaints. Am J Geriatr Psychiatry. 2016;24(9):729–37. CrossRefPubMedPubMedCentral

39.

•• Rainey-Smith SR, Gu Y, Gardener SL, Doecke JD, Villemagne VL, Brown BM, et al. Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Transl Psychiatry. 2018; This is the only study to-date investigating MeDi adherence and accumulation of cerebral Aβ longitudinally, conducted in individuals on the pathway to Alzheimer's disease. Higher MeDi adherence was associated with significantly less Aβ accumulation over three years.

40.

Mecocci P. Oxidative stress in mild cognitive impairment and Alzheimer disease: a continuum. J Alzheimers Dis. 2004;6(2):159–63. CrossRefPubMed

41.

Galimberti D, Scarpini E. Inflammation and oxidative damage in Alzheimer’s disease: friend or foe. Front Biosci. 2011;3:252–66. CrossRef

42.

Devore EE, Kang JH, Breteler MM, Grodstein F. Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol. 2012;72(1):135–43. CrossRefPubMedPubMedCentral

43.

Andres-Lacueva C, Shukitt-Hale B, Galli RL, Jauregui O, Lamuela-Raventos RM, Joseph JA. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci. 2005;8(2):111–20. CrossRefPubMed

44.

Joseph JA, Shukitt-Hale B, Willis LM. Grape juice, berries, and walnuts affect brain aging and behavior. J Nutr. 2009;139(9):1813S–7S. CrossRefPubMed

45.

Bakhtiari M, Panahi Y, Ameli J, Darvishi B. Protective effects of flavonoids against Alzheimer's disease-related neural dysfunctions. Biomed Pharmacother. 2017;93:218–29. CrossRefPubMed

46.

Urpi-Sarda M, Casas R, Chiva-Blanch G, Romero-Mamani ES, Valderas-Martinez P, Arranz S, et al. Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomakers related to atherosclerosis. Pharmacol Res. 2012;65(6):577–83. CrossRefPubMed

47.

Estruch R, Martinez-Gonzalez MA, Corella D, Salas-Salvado J, Ruiz-Gutierrez V, Covas MI, et al. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med. 2006;145(1):1–11. CrossRefPubMed

48.

Vassiliou EK, Gonzalez A, Garcia C, Tadros JH, Chakraborty G, Toney JH. Oleic acid and peanut oil high in oleic acid reverse the inhibitory effect of insulin production of the inflammatory cytokine TNF-alpha both in vitro and in vivo systems. Lipids Health Dis. 2009;8:25. CrossRefPubMedPubMedCentral

49.

Fung TT, Chiuve SE, McCullough ML, Rexrode KM, Logroscino G, Hu FB. Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women. Arch Intern Med. 2008;168(7):713–20. CrossRefPubMed

50.

Mena MP, Sacanella E, Vazquez-Agell M, Morales M, Fito M, Escoda R, et al. Inhibition of circulating immune cell activation: a molecular antiinflammatory effect of the Mediterranean diet. Am J Clin Nutr. 2009;89(1):248–56. CrossRefPubMed

51.

Chrysohoou C, Panagiotakos DB, Pitsavos C, Das UN, Stefanadis C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. J Am Coll Cardiol. 2004;44(1):152–8. CrossRefPubMed

52.

Abuznait AH, Qosa H, Busnena BA, El Sayed KA, Kaddoumi A. Olive-oil-derived oleocanthal enhances beta-amyloid clearance as a potential neuroprotective mechanism against Alzheimer’s disease: in vitro and in vivo studies. ACS Chem Neurosci. 2013;4(6):973–82. CrossRefPubMedPubMedCentral

53.

Del Rio D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G, Crozier A. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal. 2013;18(14):1818–92. CrossRefPubMedPubMedCentral

54.

Dyall SC. Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Front Aging Neurosci. 2015;7:52. CrossRefPubMedPubMedCentral

55.

Calder P. Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition of pharmacology. Br J Clin Pharmacol. 2012;75(3):645–62. CrossRef

56.

Erlinger TP, Miller ER 3rd, Charleston J, Appel LJ. Inflammation modifies the effects of a reduced-fat low-cholesterol diet on lipids: results from the DASH-sodium trial. Circulation. 2003;108(2):150–4. CrossRefPubMed

57.

Miller ER 3rd, Erlinger TP, Sacks FM, Svetkey LP, Charleston J, Lin PH, et al. A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding study. Atherosclerosis. 2005;183(1):175–82. CrossRefPubMed

58.

Blumenthal JA, Babyak MA, Hinderliter A, Watkins LL, Craighead L, Lin PH, et al. Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study. Arch Intern Med. 2010;170(2):126–35. CrossRefPubMedPubMedCentral

59.

Azadbakht L, Surkan PJ, Esmaillzadeh A, Willett WC. The Dietary Approaches to Stop Hypertension eating plan affects C-reactive protein, coagulation abnormalities, and hepatic function tests among type 2 diabetic patients. J Nutr. 2011;141(6):1083–8. CrossRefPubMedPubMedCentral

60.

Casas R, Sacanella E, Urpi-Sarda M, Chiva-Blanch G, Ros E, Martinez-Gonzalez MA, et al. The effects of the mediterranean diet on biomarkers of vascular wall inflammation and plaque vulnerability in subjects with high risk for cardiovascular disease. A randomized trial. PLoS One. 2014;9(6):e100084. CrossRefPubMedPubMedCentral

61.

Romaguera D, Norat T, Mouw T, May AM, Bamia C, Slimani N, et al. Adherence to the Mediterranean diet is associated with lower abdominal adiposity in European men and women. J Nutr. 2009;139(9):1728–37. CrossRefPubMed

62.

Estruch R, Ros E, Salas-Salvado J, Covas MI, Corella D, Aros F, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013;368(14):1279–90. CrossRefPubMed

63.

Domenech M, Roman P, Lapetra J, Garcia de la Corte FJ, Sala-Vila A, de la Torre R, et al. Mediterranean diet reduces 24-hour ambulatory blood pressure, blood glucose, and lipids: one-year randomized, clinical trial. Hypertension. 2014;64(1):69–76. CrossRefPubMed

64.

Asemi Z, Tabassi Z, Samimi M, Fahiminejad T, Esmaillzadeh A. Favourable effects of the Dietary Approaches to Stop Hypertension diet on glucose tolerance and lipid profiles in gestational diabetes: a randomised clinical trial. Br J Nutr. 2013;109(11):2024–30. CrossRefPubMed

65.

Moore TJ, Alsabeeh N, Apovian CM, Murphy MC, Coffman GA, Cullum-Dugan D, et al. Weight, blood pressure, and dietary benefits after 12 months of a web-based nutrition education program (DASH for health): longitudinal observational study. J Med Internet Res. 2008;10(4):e52. CrossRefPubMedPubMedCentral

Titel: The Role of Nutrition in Cognitive Function and Brain Ageing in the Elderly
Autoren:: Samantha L. Gardener
Stephanie R. Rainey-Smith
Publikationsdatum: 05.07.2018
DOI: https://doi.org/10.1007/s13668-018-0229-y
Verlag: Springer US
Zeitschrift: Current Nutrition Reports
Ausgabe 3/2018
Elektronische ISSN: 2161-3311

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21.02.2019 | Larynxkarzinom | Nachrichten

The Role of Nutrition in Cognitive Function and Brain Ageing in the Elderly

Abstract

Purpose of Review

Recent Findings

Summary

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Abstract

Purpose of Review

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