The role of serum levels of matrix metalloproteinases and their inhibitors in the etiology of inguinal hernia
- 01.12.2025
- Original Article
Erschienen in:
- Verfasst von
- Hasan Basoglu
- Fatih Yanar
- Berke Sengun
- Ibrahim Fethi Azamat
- Hakan Yanar
- Elif Ozkok
- Erschienen in
- Hernia | Ausgabe 1/2025
Abstract
Aim
Inguinal hernias are one of the most common operations performed worldwide, but etiopathogenesis remains important in current practice. Recent studies have frequently examined factors affecting the extracellular matrix and collagens and their association with hernias. This study aimed to investigate the role of matrix metalloproteinases (MMPs) and their inhibitors in the etiopathogenesis of inguinal hernia.
Methods
Serum samples obtained from 90 male inguinal hernia patients and 70 male control patients who presented to our clinic between March 15, 2024, and September 30, 2024, were analyzed using the ELISA method. Serum levels of matrix metalloproteinases (MMP-1, MMP-8, MMP-13) and tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2) were measured. The serum level results were compared in terms of net MMP activity, which was determined by calculating the MMP/TIMP ratios.
Results
The serum level of MMP-1 was found to be significantly higher in the hernia group (9.1 vs. 7.5; p < 0.001). No significant differences were observed in the levels of other enzymes. In terms of net MMP activity, the ratios of MMP-1/TIMP-1 (hernia: 1.1 vs. control: 0.8, p = 0.01), MMP-1/TIMP-2 (hernia: 0.3 vs. control: 0.2, p < 0.001), and MMP-13/TIMP-2 (hernia: 0.14 vs. control: 0.11, p = 0.046) were higher in the hernia group, whereas the MMP-8/TIMP-1 ratio (hernia: 4.5 vs. control: 7.0, p = 0.017) was lower.
Conclusion
In the inguinal hernia group, the serum level of MMP-1 and net MMP activity were increased, while the MMP-8/TIMP-1 ratio was decreased compared to the control group. These findings suggest that these markers may play a role in the etiopathogenesis of hernia.
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- Titel
- The role of serum levels of matrix metalloproteinases and their inhibitors in the etiology of inguinal hernia
- Verfasst von
-
Hasan Basoglu
Fatih Yanar
Berke Sengun
Ibrahim Fethi Azamat
Hakan Yanar
Elif Ozkok
- Publikationsdatum
- 01.12.2025
- Verlag
- Springer Paris
- Erschienen in
-
Hernia / Ausgabe 1/2025
Print ISSN: 1265-4906
Elektronische ISSN: 1248-9204 - DOI
- https://doi.org/10.1007/s10029-025-03477-7
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