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Erschienen in: Indian Journal of Gastroenterology 5/2016

16.08.2016 | Review Article

The role of surgery in the therapeutic approach of gastric cancer liver metastases

verfasst von: Aikaterini Mastoraki, Christina Benetou, Sotiria Mastoraki, Ioannis S. Papanikolaou, Nikolaos Danias, Vassilios Smyrniotis, Nikolaos Arkadopoulos

Erschienen in: Indian Journal of Gastroenterology | Ausgabe 5/2016

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Abstract

Gastric cancer (GC) currently prevails as the second cause of death by malignancy worldwide. Estimations suggest that 35 % of affected patients appear with synchronous distant metastases. The vast majority of patients present with hepatic metastatic disease, sometimes accompanied by synchronous peritoneal and lung dissemination. The disease mostly remains asymptomatic at an early stage, with few reported cases of incidental abdominal discomfort. As the cancer advances, symptoms such as nausea or vomiting arise, along with indigestion and dysphagia, blood loss in the form of melena or hematemesis, as well as anorexia and weight loss. Having spread to the liver, it also causes jaundice due to hepatomegaly and general inanition. Despite recent research on the therapeutic strategies against GC metastatic disease, surgical resection appears the only potentially curative approach. Unfortunately, the majority of patients are not eligible to undergo surgical intervention. With regard to treatment modalities of the advanced stage disease, the role of metastasectomy is still debatable and quite unclear, while prolonged survival was succeeded only under certain specific circumstances. Systemic chemotherapy remains however another option, as well as local management in the form of cryotherapy, radiofrequency ablation, or transcatheter arterial chemoembolization. The aims of this review were to evaluate the results of surgical treatment for metastatic GC with special reference to the extent of its histological spread and to present the recent literature in order to provide an update on the current concepts of advanced surgical management of this entity. Relevant publications in the last two decades are briefly reviewed.
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Metadaten
Titel
The role of surgery in the therapeutic approach of gastric cancer liver metastases
verfasst von
Aikaterini Mastoraki
Christina Benetou
Sotiria Mastoraki
Ioannis S. Papanikolaou
Nikolaos Danias
Vassilios Smyrniotis
Nikolaos Arkadopoulos
Publikationsdatum
16.08.2016
Verlag
Springer India
Erschienen in
Indian Journal of Gastroenterology / Ausgabe 5/2016
Print ISSN: 0254-8860
Elektronische ISSN: 0975-0711
DOI
https://doi.org/10.1007/s12664-016-0683-7

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