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Breast Cancer Research
Erschienen in: Breast Cancer Research 1/2002

01.02.2002 | Review

The role of the ubiquitination-proteasome pathway in breast cancer: Ubiquitin mediated degradation of growth factor receptors in the pathogenesis and treatment of cancer

verfasst von: Stan Lipkowitz

Erschienen in: Breast Cancer Research | Ausgabe 1/2002

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Abstract

Aberrant activity of growth factor receptors has been implicated in the pathogenesis of a wide variety of malignancies. The negative regulation of signaling by growth factor receptors is mediated in large part by the ubiquitination, internalization, and degradation of the activated receptor. Over the past few years, considerable insight into the mechanisms that control receptor downregulation has been gained. There are also data suggesting that mutations that lead to inhibition of downregulation of growth factor receptors could play a role in the pathogenesis of cancer. Therapies directed at enhancing the degradation of growth factor receptors offer a promising approach to the treatment of malignancies.
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Metadaten
Titel
The role of the ubiquitination-proteasome pathway in breast cancer: Ubiquitin mediated degradation of growth factor receptors in the pathogenesis and treatment of cancer
verfasst von
Stan Lipkowitz
Publikationsdatum
01.02.2002
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 1/2002
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr541

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