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Erschienen in: Neurological Sciences 1/2021

08.07.2020 | Original Article

The role of transcranial sonography in differentiation of dementia subtypes: an introduction of a new diagnostic method

verfasst von: Mostafa Almasi-Dooghaee, Mohammad Rohani, Atefeh Imani, Shabnam Nadjafi, Babak Zamani

Erschienen in: Neurological Sciences | Ausgabe 1/2021

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Abstract

Purpose

Transcranial sonography (TCS) is increasingly used for the diagnosis of neurodegenerative disorders. We assessed the role of third ventricle width (TVW), midbrain area (MA), and midbrain circumference (MC) by TCS for diagnosis and differentiation of dementia.

Methods

A cross-sectional study was designed in 59 patients with dementia including 19 patients with Alzheimer’s disease (AD), 10 Dementia with Lewy bodies (DLB), 23 Frontotemporal dementia (FTD) and 7 Vascular dementia (VaD), and 22 normal-cognition individuals. Both case and control groups were matched by age, sex, and educational level. The dementia patients were divided into two subgroups: cortical-dominant dementia (CDD) including AD and FTD; and subcortical-dominant dementia (SDD) including DLB and VaD. TCS was performed through a temporal window, in which the size of TVW and midbrain was measured by trans-thalamic and trans-mesencephalic planes, respectively.

Results

The mean TVW was 0.85 ± 0.3 cm and 0.66 ± 0.2 cm in dementia patients and the control group, respectively (p < 0.01). The MA/MC were smaller in dementia patients compared with the control group (p < 0.05 and p < 0.01). The TVW in CDD (p = 0.003) and SDD (p = 0.027), but only MA/MC in SDD (p < 0.05), was statistically different compared with the control group.

Conclusion

The measurement of TVW and midbrain size by TCS can be used for diagnosis and differentiation of dementia. Patients with CDD and SDD have larger TVW than the control group, whereas patients with SDD have smaller midbrain sizes.
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Metadaten
Titel
The role of transcranial sonography in differentiation of dementia subtypes: an introduction of a new diagnostic method
verfasst von
Mostafa Almasi-Dooghaee
Mohammad Rohani
Atefeh Imani
Shabnam Nadjafi
Babak Zamani
Publikationsdatum
08.07.2020
Verlag
Springer International Publishing
Erschienen in
Neurological Sciences / Ausgabe 1/2021
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-020-04566-4

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