Erschienen in:
01.06.2005 | Oral Presentation
The search for low-penetrance breast cancer genes
verfasst von:
BAJ Ponder, A Cebrian, AM Dunning, DF Easton, F Lesueur, C Luccarini, PDP Pharoah
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2005
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Excerpt
Fifteen per cent to 20% of the familial clustering of breast cancer is explained by the effects of highly penetrant mutations in BRCA1 and BRCA2. Modelling based on the patterns of familial aggregation of breast cancer in the relatives of cases ascertained on a population basis suggests that much of the remaining familial effect is due to the combined effects of genetic variants individually of small effect. The numbers of such variants, their allele frequencies and the strength of their effects is not known. …