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Annals of Nuclear Medicine

Erschienen in:

18.03.2019 | Short Communication

The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function

verfasst von: Sakiko Shimizu Handa, Shingo Baba, Kenichiro Yamashita, Mari Nishizaka, Shinichi Ando

Erschienen in: Annals of Nuclear Medicine | Ausgabe 7/2019

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Abstract

Objective

Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition.

Method

We performed polysomnography (PSG) and Aβ imaging with [¹¹C]-Pittsburgh compound B PET computed tomography (¹¹C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h).

Results

The abnormal accumulation of enhanced ¹¹C-PiB PET was observed only one patient with severe, but not the most severe.

Conclusions

The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.

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Titel: The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function
verfasst von: Sakiko Shimizu Handa
Shingo Baba
Kenichiro Yamashita
Mari Nishizaka
Shinichi Ando
Publikationsdatum: 18.03.2019
Verlag: Springer Singapore
Erschienen in: Annals of Nuclear Medicine / Ausgabe 7/2019
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-019-01349-6

Springer Medizin

Abstract

Objective

Method

Results

Conclusions

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