The online version of this article (doi:10.1186/s13601-017-0146-y) contains supplementary material, which is available to authorized users.
Recently, we have published an overview of systematic reviews in allergy epidemiology and identified asthma as the most commonly reviewed allergic disease. Building on this work, we aimed to investigate the quality of systematic reviews in asthma using the AMSTAR checklist and to provide a reference for future, more in-depth assessment of the extent of previous knowledge.
We included all 307 systematic reviews indexed with asthma, including occupational asthma, and/or wheeze from our previous search in PubMed and EMBASE up to December 2014 for systematic reviews on epidemiological research on allergic diseases. Topics of the included systematic reviews were indexed and we applied the AMSTAR checklist for methodological quality to all. Statistical analyses include description of lower and upper bounds of AMSTAR scores and variation across publication time and topics.
Of 43 topics catalogued, family history, birth weight, and feeding of formula were only covered once in systematic reviews published from 2011 onwards. Overall, at least one meta-analysis was conducted for all topics except for “social determinants”, “perinatal”, “birth weight”, and “climate”. AMSTAR quality scores were significantly higher in more recently published systematic reviews, in those with meta-analysis, and in Cochrane reviews. There was evidence of variation of quality across topics even, after accounting for these characteristics. Genetic factors in asthma development were often covered by systematic reviews with some evidence of unsubstantiated updates or repetition.
We present a comprehensive overview with an indexed database of published systematic reviews in asthma epidemiology including quality scores. We highlight some topics including active smoking and pets, which should be considered for future systematic reviews. We propose that our search strategy and database could be a basis for topic-specific overviews of systematic reviews in asthma epidemiology.
Additional file 1: Tables S1. AMSTAR checklist with “liberal” and “conservative” instructions. Table S2. Topic index terms and their aggregation. Figure S1. Profile lines of adjusted mean liberal and conservative AMSTAR scores across topics.
Additional file 2. Full indexed list of the included systematic reviews including AMSTAR scores.
Akdis CA, Agache I, editors. Global atlas of asthma. Zürich: EAACI; 2013.
Gibson G, Loddenkemper R, Sibille Y, editors. The European lung white book. 2nd ed. Sheffield: European Respiratory Society; 2013.
King ME, Mannino DM, Holguin F. Risk factors for asthma incidence. A review of recent prospective evidence. Panminerva Med. 2004;46:97–110. PubMed
Contopoulos-Ioannidis DG, Kouri IN, Ioannidis JPA. Genetic predisposition to asthma and atopy. Respir Int Rev Thorac Dis. 2007;74:8–12.
Genuneit J, Seibold AM, Apfelbacher CJ, Konstantinou GN, Koplin JJ, La Grutta S, Logan K, Perkin MR, Flohr C, Task Force ‘Overview of Systematic Reviews in Allergy Epidemiology (OSRAE)’ of the EAACI Interest Group on Epidemiology. Overview of systematic reviews in allergy epidemiology. Allergy. 2017. doi: 10.1111/all.13123.
Jarahi L, Shojaie SRH. Long-term effects of sulfur mustard poisoning in iranian chemical warfare victims: a systematic review (English). J Isfahan Med Sch. 2013;30:2353–66.
Tang L, Chen J, Shen Y. [Meta-analysis of probiotics preventing allergic diseases in infants]. Zhonghua Er Ke Za Zhi Chin J Pediatr. 2012;50:504–9.
Himathongkam T, Nicogossian A, Kloiber O, Ebadirad N. Updates of secondhand smoke exposure on infants’ and children’s health. World Med Health Policy. 2013;5:124–40. CrossRef
Drysdale SB, Milner AD, Greenough A. Respiratory syncytial virus infection and chronic respiratory morbidity: is there a functional or genetic predisposition? Acta Paediatr Oslo Nor. 1992;2012(101):1114–20.
Rodríguez E, Baurecht H, Herberich E, Wagenpfeil S, Brown SJ, Cordell HJ, et al. Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease. J Allergy Clin Immunol. 2009;123(1361–1370):e7.
- The state of asthma epidemiology: an overview of systematic reviews and their quality
Annina M. Seibold
Christian J. Apfelbacher
George N. Konstantinou
Jennifer J. Koplin
Stefania La Grutta
Michael R. Perkin
for the Task Force “Overview of Systematic Reviews in Allergy Epidemiology (OSRAE)” of the EAACI Interest Group on Epidemiology
- BioMed Central
Neu im Fachgebiet HNO
Mail Icon II