Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Konkret geht es um den Diabetes-Patienten mit kardiovaskulären Erkrankungen oder Risiken, die Herzinsuffizienz sowie die kardiovaskuläre Primär- und Sekundärprävention. Sind Sie hier schon auf dem neuesten Stand? Unsere Experten beleuchten, wo und warum das bisherige Procedere geändert werden soll und was in der Praxis sinnvoll ist. Holen Sie sich Ihr Update und 2 CME-Punkte beim MMW-Webinar am 24. April von 17.30 bis 19 Uhr. 
Erweiterte Suche
Anmelden
nach oben
Current Sexual Health Reports
Erschienen in: Current Sexual Health Reports 4/2017

02.11.2017 | Medical Comorbidities (M Miner, S Parish and A Goldstein, Section Editors)

The Testosterone Trials: What the Results Mean for Healthcare Providers and for Science

verfasst von: Abraham Morgentaler

Erschienen in: Current Sexual Health Reports | Ausgabe 4/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

The purpose of this review was to assess the results of the Testosterone (T) Trials with regard to their clinical and scientific implications.

Recent Findings

The T Trials investigated 1 year of T gel versus placebo in 790 men 65 years and older with unequivocally low serum T concentrations (< 275 ng/dl). Safety monitoring was performed for an additional year. Primary results were improvement over placebo for sexual desire, sexual activity, erection quality, physical activity, and mood. Vitality improved with some instruments, but not all. Improvement was noted in bone density and anemia. Coronary CT provided mixed results—coronary calcium scores were unchanged whereas volume of non-calcified plaque increased more in the testosterone group. There were no worrisome safety concerns. Major adverse cardiovascular events over 2 years occurred in 9 testosterone-treated men and 16 placebo-treated men.

Summary

The T Trials provide high-level evidence of strong, broad benefits of T therapy, without substantive safety concerns.
Literatur
1.
•• Snyder PJ, Bhasin S, Cunningham GR, Matsumoto AM, Stephens-Shields AJ, Cauley JA, et al. Effects of testosterone treatment in older men. N Engl J Med. 2016;374(7):611–24. This article provides the primary results of the Testosterone Trials.
2.
Cunningham GR, Stephens-Shields AJ, Rosen RC, Wang C, Bhasin S, Matsumoto AM, et al. Testosterone treatment and sexual function in older men with low testosterone levels. J Clin Endocrinol Metab. 2016 Aug;101(8):3096–104.
3.
Snyder PJ, Kopperdahl DL, Stephens-Shields AJ, Ellenberg SS, Cauley JA, Ensrud KE, et al. Effect of testosterone treatment on volumetric bone density and strength in older men with low testosterone: a controlled clinical trial. JAMA Intern Med. 2017;177(4):471–9.
4.
Roy CN, Snyder PJ, Stephens-Shields AJ, Artz AS, Bhasin S, Cohen HJ, et al. Association of testosterone levels with anemia in older men: a controlled clinical trial. JAMA Intern Med. 2017;177(4):480–90.
5.
• Budoff MJ, Ellenberg SS, Lewis CE, Mohler ER 3rd, Wenger NK, Bhasin S, et al. Testosterone treatment and coronary artery plaque volume in older men with low testosterone. JAMA. 2017;317(7):708–16. This paper provides coronary computed tomography results from a sub-study within the Testosterone Trials.
6.
Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA. 2002;288(3):321–33.
7.
•• Traish AM, Vance JC, Morgentaler A. Overselling hysteria: the role of the media and medical journals in promoting questionable risks—a case study of the testosterone controversy. Embo Rep. 2017;18:11–7. This paper uses testosterone as a case example to show how the media and medical journals unwittingly collaborate to create exaggerated concerns regarding medical risks. CrossRefPubMed
8.
Aub JC. Reports on medical progress. Endocrines: the use of testosterone. N Engl J Med. 1940;222:877–81.CrossRef
9.
Wu FC, Tajar A, Beynon JM, Pye SR, Silman AJ, Finn JD, et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med. 2010;363(2):123–35.
10.
Corona G, Rastrelli G, Morgentaler A, Sforza A, Mannucci E, Maggi M. Meta-analysis of results of testosterone therapy on sexual function based on International Index of Erectile Function Scores. Eur Urol 2017. doi:10.​1016/​j.​eururo.​2017.​03.​032.​
11.
Hackett G, Cole N, Bhartia M, Kennedy D, Raju J, Wilkinson P, et al. The response to testosterone undecanoate in men with type 2 diabetes is dependent on achieving threshold serum levels (the BLAST study). Int J Clin Pract. 2014;68(2):203–15.
12.
Morgentaler A, Crews D. Role of the anterior hypothalamus-preoptic area in the regulation of reproductive behavior in the lizard, Anolis carolinensis: implantation studies. Horm Behav. 1978;11:61.CrossRef
13.
• Morgentaler A. Controversies and advances with testosterone therapy: a 40-year perspective. Urology. 2016;89:27–32. This paper provides a broad perspective on testosterone therapy by a clinician-scientist. CrossRefPubMed
14.
Sakr WA, Grignon DJ, Crissman JD, et al. High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20–69: an autopsy study of 249 cases. In Vivo. 1994;8:439–43.PubMed
15.
Shigehara K, Sugimoto K, Konaka H, Iijima M, Fukushima M, Maeda Y, et al. Androgen replacement therapy contributes to improving lower urinary tract symptoms in patients with hypogonadism and benign prostate hypertrophy: a randomised controlled study. Aging Male. 2011 Mar;14(1):53–8.
16.
Morgentaler A, Traish A. Shifting the paradigm of testosterone and prostate cancer: the saturation model and the limits of androgen-dependent growth. Eur Urol. 2009;55:310–20.CrossRefPubMed
17.
Morgentaler A, Benesh JA, Denes BS, Kan-Dobrosky N, Harb D, Miller MG. Factors influencing prostate-specific antigen response among men treated with testosterone therapy for 6 months. J Sex Med. 2014 Nov;11(11):2818–25.CrossRefPubMed
18.
Vigen R, O’Donnell CI, Baron AE, et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA. 2013;310(17):1829–36.CrossRefPubMed
19.
Finkle WD, Greenland S, Ridgeway GK, et al. Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men. Plos One. 2014;9(1):76.CrossRef
20.
Wallis CJ, Lo K, Lee Y, Krakowsky Y, et al. Survival and cardiovascular events in men treated with replacement therapy: an intention-to-treat observational cohort study. Lancet Diabetes Endocrinol. 2016;4:498–506.CrossRefPubMed
21.
Sharma R, Oni OA, Gupta K, Barua, et al. Normalization of testosterone level is associated with reduced incidence myocardial infarction and mortality in men. Eur Heart J. 2015;36(40):2706–015.
22.
• Morgentaler A, Miner MM, Caliber M, et al. Testosterone therapy and cardiovascular risk: advances and controversies. Mayo Clin Proc. 2015;90:224–51. Comprehensive review of evidence regarding cardiovascular risks of testosterone. CrossRefPubMed
23.
Finkelstein JS, Lee H, Burnett-Bowie SA, Pallais JC, EW Y, Borges LF, et al. Gonadal steroids and body composition, strength, and sexual function in men. N Engl J Med. 2013;369(11):1011–22.
24.
• Nguyen CP, Hirsch MS, Moeny D, Kaul S, Mohamoud M, Joffe HV. Testosterone and “age-related hypogonadism”—FDA concerns. N Engl J Med. 2015;373(8):689–91. In this commentary, the FDA provides arguments in favor of its controversial actions to restrict the use of testosterone. CrossRefPubMed
Metadaten
Titel
The Testosterone Trials: What the Results Mean for Healthcare Providers and for Science
verfasst von
Abraham Morgentaler
Publikationsdatum
02.11.2017
Verlag
Springer US
Erschienen in
Current Sexual Health Reports / Ausgabe 4/2017
Print ISSN: 1548-3584
Elektronische ISSN: 1548-3592
DOI
https://doi.org/10.1007/s11930-017-0135-0

Weitere Artikel der Ausgabe 4/2017

Current Sexual Health Reports 4/2017 Zur Ausgabe

Male and Female Surgical Interventions (A Burnett and C Carson, Section Editors)

An Update on the Management of the Short Penis: Results from a Systematic Review

Preclinical and Psychophysiology (F Guarraci and L Marson, Section Editors)

Sexual Transmission of Cyst-Forming Coccidian Parasites with Complex Life Cycles

Male and Female Surgical Interventions (A Burnett and C Carson, Section Editors)

Surgical Management of the Concealed Penis in Adults

Preclinical and Psychophysiology (F Guarraci and L Marson, Section Editors)

The Role of Ovarian Hormones and the Medial Amygdala in Sexual Motivation

Medical Comorbidities (M Miner, S Parish and A Goldstein, Section Editors)

Vascular Erectile Dysfunction and Subclinical Cardiovascular Disease

Medical Comorbidities (M Miner, S Parish and A Goldstein, Section Editors)

Testosterone and Physical Function

Neu im Fachgebiet Urologie

22.04.2024 | Prostatakarzinom | Nachrichten

Stufenschema weist Prostatakarzinom zuverlässig nach

20.04.2024 | EAU 2024 | Kongressbericht | Nachrichten

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

19.04.2024 | EAU 2024 | Kongressbericht | Nachrichten

Varikozelen bei Jugendlichen: Das Für und Wider der Operation

19.04.2024 | EAU 2024 | Kongressbericht | Nachrichten

Ureterstriktur: Innovative OP-Technik bewährt sich
weitere anzeigen

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen