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01.12.2018 | Review article | Ausgabe 1/2018 Open Access

Environmental Health and Preventive Medicine 1/2018

The toxicological mechanisms and detoxification of depleted uranium exposure

Zeitschrift:
Environmental Health and Preventive Medicine > Ausgabe 1/2018
Autoren:
Yong-Chao Yue, Ming-Hua Li, Hai-Bo Wang, Bang-Le Zhang, Wei He

Abstract

Depleted uranium (DU) has been widely applied in industrial and military activities, and is often obtained from producing fuel for nuclear reactors. DU may be released into the environment, polluting air, soil, and water, and is considered to exert both radiological and chemical toxicity. In humans and animals, DU can induce multiple health effects, such as renal tubular necrosis and bone malignancies. This review summarizes the known information on DU’s routes of entry, mechanisms of toxicity, and health effects. In addition, we survey the chelating agents used in ameliorating DU toxicity.

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