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Targeted Oncology

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29.08.2016 | Review Article

The Unexpected Roles of Aurora A Kinase in Gliobastoma Recurrences

verfasst von: Estelle Willems, Arnaud Lombard, Matthias Dedobbeleer, Nicolas Goffart, Bernard Rogister

Erschienen in: Targeted Oncology | Ausgabe 1/2017

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Abstract

The main obstacle for the cure of glioblastoma (GBM) is systematic tumor recurrence after treatment. More than 90 % of GBM tumors are indeed recurrent within 5 years after diagnosis and treatment. We urgently need new therapies to specifically address these deadly relapses. A major advance in the understanding of GBM recurrence is the identification of GBM-Initiating Cells (GIC), characterized by their abilities for self-renewal, multilineage differentiation, and proliferation. It appears that these features of GIC could be modulated by the mitotic kinase Aurora A (AurA). Indeed, besides its role in mitosis, AurA has recently been identified to regulate alternative functions like cell polarity, asymmetric cell division, and epithelial to mesenchymal transition. All these properties may help explain GBM therapeutic resistance and recurrence. In this review, we make the hypothesis that AurA could significantly contribute to GBM recurrences and we focus on the possible roles of AurA in GIC.

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Titel: The Unexpected Roles of Aurora A Kinase in Gliobastoma Recurrences
verfasst von: Estelle Willems
Arnaud Lombard
Matthias Dedobbeleer
Nicolas Goffart
Bernard Rogister
Publikationsdatum: 29.08.2016
Verlag: Springer International Publishing
Erschienen in: Targeted Oncology / Ausgabe 1/2017
Print ISSN: 1776-2596
Elektronische ISSN: 1776-260X
DOI: https://doi.org/10.1007/s11523-016-0457-2

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The Unexpected Roles of Aurora A Kinase in Gliobastoma Recurrences

Abstract

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

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