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16.03.2016 | Original Article | Ausgabe 1/2016 Open Access

Strategies in Trauma and Limb Reconstruction 1/2016

The use of recombinant morphogenic protein-2(rhBMP-2) in children undergoing revision surgery for persistent non-union

Strategies in Trauma and Limb Reconstruction > Ausgabe 1/2016
Madhavan C. Papanna, K. A. Saldanha, Binu Kurian, James A. Fernandes, Stan Jones


The purpose of the study was to evaluate the safety and efficacy with the use of BMP-2 for treating persistent non-unions in children with underlying complex conditions. Between October 2006 and November 2010 in our unit, 15 patients were treated with rhBMP-2 to enhance bone union. There were nine females and six males with a mean age of 9.5 years (range 4–15) at time of surgery. Seventy-five per cent of the patients required revision of internal fixation with insertion of rhBMP-2 to the non-union site, and the reminder had freshening of the non-union site with rhBMP-2 application. Patients had undergone a mean of 2 (1–5) operations prior to implantation of rhBMP-2. All the patients in the study group were available for review with mean follow-up of 44 months (range 21–70). The mean time to union was 16 weeks (range 10–28 weeks). No adverse events related to BMP-2 application were noted in our study group. Healing occurred clinically and radiographically in 16 of the 17 sites. Our study demonstrates that BMP-2 enhances healing of the persistent non-unions without any adverse events
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