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01.12.2014 | Brief Report | Ausgabe 12/2014

AIDS and Behavior 12/2014

The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

AIDS and Behavior > Ausgabe 12/2014
Jane M. Simoni, David Huh, Yan Wang, Ira B. Wilson, Nancy R. Reynolds, Robert H. Remien, Kathy Goggin, Robert Gross, Marc I. Rosen, Neil Schneiderman, Julia Arnsten, Carol E. Golin, Judith A. Erlen, David R. Bangsberg, Honghu Liu
Wichtige Hinweise
Meeting at which parts of the data were presented: 7th NIMH/IAPAC International Conference on HIV Treatment and Prevention Adherence, June 3-5, 2012, Miami, FL.


In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher’s aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [1], electronically monitored adherence and [2] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.

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