11.08.2023 | Correspondence
The variance in phosphorylated, insoluble ⍺-synuclein in humans, rats, and mice is not mainly driven by biological sex
verfasst von:
Kristin M. Miner, Anuj S. Jamenis, Tarun N. Bhatia, Rachel N. Clark, Muslim Abbas, Kelvin C. Luk, Rehana K. Leak
Erschienen in:
Acta Neuropathologica
|
Ausgabe 4/2023
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Excerpt
As all lifeforms must display sensitivity to surrounding chemicals, the mammalian olfactory bulb (OB) and its peripheral fibers have evolved to sample the air. However, this structural blueprint may enable transmission of disease triggers into the rhinencephalon (nose–brain). For example, the OB and olfactory peduncle may be affected with Lewy pathology in early stages of dementia with Lewy bodies (DLB) and Parkinson’s disease (PD), particularly in cases with amygdalar predominance [
1,
2,
5,
6]. The olfactory peduncle (i.e., foot) connects the OB with the forebrain and encompasses the anterior olfactory nuclei (AON) and tenia tectae [
7]. The OB and olfactory peduncle are rostral components of
le grand lobe limbique, defined by Broca as the
limbus (border) of the cortex (Fig. 1 in [
13]). However, the modern view of the limbic system centers on the amygdala, a nuclear complex operating in support of emotional regulation. …
