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Erschienen in: BMC Nephrology 1/2019

Open Access 01.12.2019 | Research article

The vascular access questionnaire: a single centre UK experience

verfasst von: M. Field, A.Z Khawaja, J. Ellis, T. Nieto, J. Hodson, N. Inston

Erschienen in: BMC Nephrology | Ausgabe 1/2019

Abstract

Background

Haemodialysis is capable of prolonging life in patients with end stage renal disease, however this therapy comes with significant negative impact on quality of life. For patients requiring haemodialysis, the need for an adequately functioning vascular access (VA) is an everyday concern. The Vascular Access Questionnaire (VAQ) provides a mechanism for identifying and scoring factors in haemodialysis that impact on patients’ quality of life and perception of their therapy.

Methods

Between April 2017–18 the VAQ was administered to prevalent haemodialysis patients at 10 units in the West Midlands via structured interviews.

Results

749 of 920 potentially eligible patients completed the survey. The mean VAQ score was seen to improve significantly with age (7.7 in < 55 vs. 3.8 in 75+) and the duration of access (8.9 if less than 1 month old vs. 5.0 at a year). Better average scores were demonstrated for Arteriovenous fistulas (AVF) than other modalities (AVF 5.1 vs. AVG (arteriovenous grafts) 7.2 vs. CVC (central venous catheter) 6.6). There was no significant difference in scores between fistulas on non-dominant or dominant arms, with both having a mean of 5.2 (p = 0.341).

Conclusions

Overall, better satisfaction scores were seen in AVF. The presence of an AVF on the non-dominant arm was not a concern for the majority of patients and did not affect the VAQ score. A number of factors were identified that can influence VAQ satisfaction score.
Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12882-019-1493-9) contains supplementary material, which is available to authorized users.

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Abkürzungen
ADL
Activity of daily living
AVF
Arteriovenous fistula
AVG
Arteriovenous graft
CVC
Central venous catheter
HRQL
Health related quality of life
IQR
Interquartile range
OR
Odds ratio
QoL
Quality of life
VA
Vascular Access
VAQ
Vascular Access Questionnaire

Background

Guidelines, best practice policies and quality improvement initiatives support a hierarchy of arteriovenous fistulas (AVFs), arteriovenous grafts (AVGs) and central venous catheters (CVCs) as a last choice, with regards to permanent form of Vascular Access (VA) [1]. These recommendations are based on associated clinical outcomes derived from population studies. These so called “hard outcome measures” are increasingly recognized as deficient in factors important to patients, and may not be the only way of comparing different options for the patient [2].
For patients with chronic kidney disease, multiple aspects of care can impact on quality of life [3]. Haemodialysis patients consistently have lower Quality of Life (QoL) scores than patients who are pre-dialysis or have a transplant [4]. Previous studies demonstrated a negative impact of a CVCs [5, 6]. However, these studies only reported small difference in Health Related Quality of Life (HRQL) between different access modalities, despite there being differences in the reported Vascular Access Questionnaire scores (VAQ) [7] .
A patient’s vascular access is a visible reminder of their reliance on a dialysis and that they have a life threatening disease. All forms of VA require maintenance and are associated with complications and can impact on the patients overall quality of life [8].
The patient experience or satisfaction with their vascular access may play an important role in their choices for vascular access [9]. Previous studies have suggested that patients are concerned with the physical aspects of AVFs, particularly their appearance, associated pain and bleeding. The choice between the pain of having an AVF cannulated versus the needle free benefit of a CVC are a striking example. Previous work has suggested that these concerns are more important to patients and outweigh the potential benefits of an AVF, such as lower infection rate [10, 11].
Defining and a better understanding of patient’s views and experiences is fundamental to tailoring individualised care, addressing concerns to improve AVF uptake and quality of care of the patient as a whole.
The Vascular Access Questionnaire (VAQ) was described in 2008 by Quinn et al. and consists of a patient-reported questionnaire composed of 17 vascular access related questions (Additional file 1: Table S1), with responses on a five-point Likert scale which are summed, to give a Vascular Access Score, a lower overall score indicating greater satisfaction. Quinn et al. analysed responses from 222 patients and, although no statistically significant differences were revealed between AVF and CVC scores, patients with AVFs tended to be more concerned by physical symptoms (pain, bleeding, bruising) than patients with a CVC [11, 12].
The aim was to apply the VAQ in a regional, multi-ethnic dialysis population, to identify patient characteristics that influence their perception and outcomes of VA, with the aim of defining areas for quality improvement initiatives, including improvement of the information and service our patients receive.

Methods

Between April 2017 and April 2018, the VAQ was administered to in-centre patients established on haemodialysis at ten dialysis units within a UK region (West Midlands) served by the Queen Elizabeth Hospital, Birmingham. All patients undergoing haemodialysis in the chronic centres who were able to consent were approached. Patients undergoing dialysis on the acute unit or home haemodialysis were excluded.
A data collection instrument collected responses to the VAQ, demographics, comorbidities, vascular access history and interventions, and treatment satisfaction. Questions gauged the patient’s perception of the dialysis nurse’s attitude to their access and their view on the best access option for their health. In addition, three open ended, free response questions were included to assess:
1)
whether patients felt they had received sufficient access information prior to starting dialysis
 
2)
reasons for not considering an AVF in patients with a CVC
 
3)
issues with AVF on the patient’s dominant arm.
 
The interview was conducted in the patients preferred language. Non-participation reason data was also recorded.
Data was managed using REDCap electronic data capture instrument hosted at the University of Birmingham [13] and exported for analysis to IBM SPSS 22 (IBM Corp. Armonk, NY), and Prism version 7.0. Institutional audit approval was granted (CARMS-12695).

Statistical methods

VAQ scores had a highly skewed distribution, and so were reported as medians and interquartile ranges (IQRs). However, since the VAQ score produced discrete values, this approach lacked the granularity to clearly demonstrate differences between groups. As a result, the scores were also summarised using means. Comparisons across nominal factors were performed using Mann-Whitney or Kruskal-Wallis groups where there were two or more than two groups, respectively. Significant Kruskal-Wallis tests were followed by post-hoc pairwise comparisons using Dunn’s test. For ordinal and continuous factors, Spearman’s rho correlations were used to assess the significance of any associations. A multivariable analysis was then performed, to identify independent predictors of the VAQ score. Due to the distribution of the score, it was not possible to produce a reliable linear regression model. Instead, the scores were dichotomised, based on the upper quartile of the distribution, with the resulting variable set as the dependent variable in a binary logistic regression model.
Subgroup analyses were then performed, to assess the differences between the scores for the individual component questions of the VAQ score across a range of demographic and access-related factors. All analyses were performed using IBM SPSS 22 (IBM Corp. Armonk, NY), with p < 0.05 deemed to be indicative of statistical significance throughout.

Results

Demographics

Nine hundred twenty patients were identified and 749 patients (81.4%) completed the survey. Of those who did not complete the survey, 64.3% (n = 110) were not present at the time of the visit to their dialysis unit, 16.4% (n = 28) did not want to participate and 19.3% (n = 33) could not consent.
The 749 patients included had a median age of 65 years (IQR: 55–76), 57.8% were male and 49.3% White ethnicity. The median length of haemodialysis was 3 years (IQR: 2–7) and the majority had an AVF (72.0%) as their mode of vascular access. Further details in Tables 1, 2, 3 and 4.
Table 1
Patient Demographics
 
Total N
 
VAQ Score
 
N (%)
Mean
Median (IQR)
p-Value
Age (Years)
749
   
<0.001*
<55
 
175 (23.4%)
7.7
6 (2–11)
 
55–64
 
183 (24.4%)
6.2
4 (1–8)
 
65–74
 
178 (23.8%)
4.9
3 (1–7)
 
75+
 
213 (28.4%)
3.8
3 (1–6)
 
Gender
749
   
<0.001
Female
 
316 (42.2%)
6.7
5 (2–10)
 
Male
 
433 (57.8%)
4.7
3 (1–7)
 
Ethnicity
748
   
<0.001
White
 
369 (49.3%)
5.5
4 (2–8)
 
Asian
 
252 (33.7%)
5.2
3 (0–7)
 
Black
 
124 (16.6%)
6.4
5 (2–10)
 
Mixed
 
3 (0.4%)
4.7
3 (3–8)
 
Peripheral Vascular Disease
749
   
0.011
No
 
641 (85.6%)
5.3
3 (1–8)
 
Yes
 
108 (14.4%)
7.2
5 (2–10)
 
Cardiac disease
749
   
0.055
No
 
503 (67.2%)
5.2
3 (1–7)
 
Yes
 
246 (32.8%)
6.2
4 (1–9)
 
Diabetes
749
   
0.195
No
 
450 (60.1%)
5.8
4 (1–9)
 
Diet Controlled
 
66 (8.8%)
4.2
3 (1–6)
 
Tablet Controlled
 
42 (5.6%)
4.0
3 (0–7)
 
Insulin
 
191 (25.5%)
5.8
4 (1–8)
 
Unit
749
   
<0.001
Unit 1
 
43 (5.7%)
3.6
2 (0–4)
 
Unit 2
 
90 (12.0%)
4.5
3 (1–7)
 
Unit 3
 
116 (15.5%)
4.6
3 (0–7)
 
Unit 4
 
68 (9.1%)
5.1
4 (2–8)
 
Unit 5
 
79 (10.5%)
5.3
3 (1–7)
 
Unit 6
 
72 (9.6%)
5.3
3 (1–7)
 
Unit 7
 
96 (12.8%)
6.1
5 (2–8)
 
Unit 8
 
75 (10.0%)
6.3
4 (1–9)
 
Unit 9
 
56 (7.5%)
7.8
7 (2–12)
 
Unit 10
 
54 (7.2%)
7.6
7 (4–12)
 
Years of Haemodiaysis
748
   
0.235*
<2
 
188 (25.1%)
5.1
3 (1–8)
 
2–3
 
197 (26.3%)
5.2
3 (1–7)
 
4–7
 
188 (25.1%)
6.0
4 (2–9)
 
8+
 
175 (23.4%)
5.7
4 (1–8)
 
p-Values are from Mann-Whitney or Kruskal-Wallis tests, unless stated otherwise, and bold p-values are significant at p < 0.05
*p-Value from Spearman’s rho, as the factor is ordinal
Table 2
Current access
 
Total
 
VAQ Score
 
N
N (%)
Mean
Median (IQR)
p-Value
Current Mode of Vascular Access
749
   
0.004
AVF
 
539 (72.0%)
5.1
3 (1–7)
 
AV graft
 
34 (4.5%)
7.2
5 (3–10)
 
CVC
 
174 (23.2%)
6.6
5 (1–9)
 
CVC and Fistula
 
2 (0.3%)
10.0
10 (10–10)
 
Duration of Current Access?
748
   
0.003*
<1 month
 
19 (2.5%)
8.9
8 (4–12)
 
1 month - 6 months
 
101 (13.5%)
6.2
4 (2–9)
 
6 months − 12 months
 
98 (13.1%)
7.1
5 (1–11)
 
over 1 year
 
530 (70.9%)
5.0
3 (1–7)
 
Current Fistula**
538
   
0.229
Brachiobasilic
 
53 (9.9%)
5.6
3 (2–8)
 
Brachiocephalic
 
273 (50.7%)
5.2
3 (1–7)
 
Radiocephalic
 
212 (39.4%)
4.7
3 (1–7)
 
Current Graft**
34
   
0.090
Lower arm
 
2 (5.9%)
1.5
2 (0–3)
 
Upper arm
 
27 (79.4%)
7.0
5 (2–9)
 
Upper leg
 
5 (14.7%)
10.4
12 (10–13)
 
Current CVC**
174
   
0.120
Femoral
 
15 (8.6%)
10.9
10 (2–19)
 
Jugular
 
154 (88.5%)
6.3
5 (2–9)
 
Other
 
5 (2.9%)
6.4
7 (1–8)
 
Fistula/Graft on Dominant Arm***
570
   
0.341
No
 
445 (78.1%)
5.2
3 (1–7)
 
Yes
 
125 (21.9%)
5.2
3 (2–7)
 
Does This Cause Issues?****
125
   
0.002
No
 
88 (70.4%)
4.3
3 (1–7)
 
Yes
 
37 (29.6%)
7.4
6 (3–8)
 
p-Values are from Mann-Whitney or Kruskal-Wallis tests, unless stated otherwise, and bold p-values are significant at p < 0.05
*p-Value from Spearman’s rho, as the factor is ordinal
**For the subgroup of patients with the stated access type
***Excludes N = 5 with leg grafts
****Does having the fistula/graft on the dominant arm cause issues, in those where this question was applicable
Table 3
Previous access
 
Total
 
VAQ Score
p-Value
N
N (%)
Mean
Median (IQR)
Any Previous Access**
749
   
<0.001
No
 
601 (80.2%)
5.0
3 (1–7)
 
Yes
 
148 (19.8%)
7.8
6 (2–12)
 
Previous CVC**
749
   
<0.001
No
 
644 (86.0%)
5.2
3 (1–7)
 
Yes
 
105 (14.0%)
7.9
6 (3–12)
 
Previous Fistula**
749
   
0.903
No
 
712 (95.1%)
5.5
4 (1–8)
 
Yes
 
37 (4.9%)
6.9
4 (1–7)
 
Previous Graft**
749
   
0.194
No
 
737 (98.4%)
5.5
4 (1–8)
 
Yes
 
12 (1.6%)
8.3
7 (2–13)
 
Number of Previous CVC
748
   
<0.001*
0
 
244 (32.6%)
4.7
3 (1–7)
 
1 to 5
 
437 (58.4%)
5.4
4 (1–8)
 
6 to 10
 
47 (6.3%)
9.6
7 (3–14)
 
>10
 
20 (2.7%)
9.8
8 (3–18)
 
Radiological Intervention
On Graft/Fistula***
575
   
<0.001
No
 
428 (74.4%)
4.6
3 (1–7)
 
Yes
 
147 (25.6%)
7.0
5 (2–10)
 
On CVC***
175
   
0.760
No
 
139 (79.4%)
6.5
5 (2–9)
 
Yes
 
36 (20.6%)
7.6
6 (1–11)
 
p-Values are from Mann-Whitney or Kruskal-Wallis tests, unless stated otherwise, and bold p-values are significant at p < 0.05
*p-Value from Spearman’s rho, as the factor is ordinal
**Previous access in the year prior to questioning. Categories are not mutually exclusive – respondents were asked to tick all that applied
***In the last year, in those patients who had been treated with the stated access type
Table 4
Satisfaction with Treatment
 
Total
 
VAQ Score
p-Value
N
N (%)
Mean
Median (IQR)
Satisfaction with Current Access
748
   
<0.001*
Very Dissatisfied
 
4 (0.5%)
8.0
8 (5–11)
 
Somewhat Dissatisfied
 
17 (2.3%)
11.1
9 (6–15)
 
Somewhat Satisfied
 
83 (11.1%)
10.3
8 (5–15)
 
Very Satisfied
 
644 (86.1%)
4.8
3 (1–7)
 
Recommend Current Access
748
   
<0.001*
No
 
37 (4.9%)
8.6
6 (4–12)
 
Maybe Not
 
29 (3.9%)
7.9
9 (3–11)
 
Maybe
 
59 (7.9%)
7.5
6 (2–12)
 
Yes
 
623 (83.3%)
5.1
3 (1–7)
 
Access Easy to Use?
747
   
<0.001*
Very Difficult
 
3 (0.4%)
22.0
19 (7–40)
 
Somewhat Difficult
 
23 (3.1%)
11.2
9 (6–15)
 
Somewhat Easy
 
112 (15.0%)
7.1
6 (2–9)
 
Very Easy
 
609 (81.5%)
5.0
3 (1–7)
 
Which do Nurses Prefer?
744
   
0.352
AVF
 
270 (36.3%)
5.5
3 (1–7)
 
Equally Happy
 
177 (23.8%)
5.7
4 (1–8)
 
CVC
 
71 (9.5%)
5.8
5 (2–9)
 
Not Sure
 
226 (30.4%)
5.4
4 (1–8)
 
Which is Better for Your Health?
748
   
0.414
AVF
 
553 (73.9%)
5.7
4 (1–8)
 
No Difference
 
39 (5.2%)
4.7
4 (0–7)
 
CVC
 
52 (7.0%)
4.4
3 (1–6)
 
Not Sure
 
104 (13.9%)
5.3
4 (2–7)
 
p-Values are from Mann-Whitney or Kruskal-Wallis tests, unless stated otherwise, and bold p-values are significant at p < 0.05
*p-Value from Spearman’s rho, as the factor is ordinal

Factors associated with the VAQ score

The VAQ score followed a skewed distribution, with a mean of 5.5 and a median of 4 (IQR: 1–8). The associations between the score and a range of demographic factors are reported in Table 1. The VAQ score was found to improve significantly (lower scores) with age (p < 0.001), from a mean of 7.7 in those aged < 55 years to 3.8 in those that were 75+ years, and to be significantly worse (higher scores) in females (mean: 6.7 vs. 4.7 in males, p < 0.001). A significant difference between ethnicities was detected (p = 0.001), with post-hoc analysis finding that Asian patients (mean: 5.2) had significantly better (lower) scores than those of either White (mean: 5.5) or Black (mean: 6.4) ethnicity.
Patients with a history of peripheral vascular disease had significantly worse (higher) VAQ scores (mean: 7.2 vs. 5.3, p = 0.011). Subgroup analysis (Additional file 1: Table S2) found that this difference in VAQ was largest in diabetic patients (mean: 8.1 vs. 4.4, p = 0.001), with no significant difference in VAQ by peripheral vascular disease in the non-diabetic cohort (mean: 6.0 vs. 5.8, p = 0.556).
There was no significant association with either cardiac disease (p = 0.055), diabetes (p = 0.195) or the overall duration of haemodialysis (p = 0.235). However, VAQ scores were found to differ significantly between dialysis units (p < 0.001), with means ranging from 3.6–7.8 (p < 0.001).
Associations between the VAQ score and factors related to the current access are assessed in Table 2. The score was found to vary significantly with the mode of vascular access (p = 0.004). Post-hoc analysis found patients with CVC scored significantly worse than those with AVF (mean: 6.6 vs. 5.1). Within each modality, no significant differences were detected between the anatomical locations of access. However, the VAQ was found to improve significantly with the duration of the current access (p = 0.003), from a mean of 8.9 at < 1 month, to 5.0 for those that were over a year. For the subset of patients with grafts or AVF, VAQ was not found to differ significantly between those where this was in the dominant vs. non-dominant arm (p = 0.341).
For patients with grafts and AVF, those requiring radiology intervention in the previous year had a significantly worse score (mean: 7.0 vs. 4.6, p < 0.001), although this trend was not observed in those with CVCs (p = 0.719, Table 3). Increasing numbers of previous CVC were associated with significantly worse VAQ scores, with means of 4.7 for those with no previous CVC, compared to 9.8 in those with > 10 CVC (p < 0.001).
Increasing satisfaction with the current access as well as its ease of use were associated with significantly better scores (all p < 0.001). Patients with a likelihood of recommending the current access also scored better (p < 0.001) (Table 4).
To identify independent predictors of the VAQ score a multivariable analysis was performed. The score was dichotomised based on the upper quartile, with VAQ > 7 treated as a “high” score (N = 203, 26.4%). The demographic factors from Table 5 were included in the model, the mode and duration of the current access, number of previous CVC and need for radiological interventions in the previous year. This model identified younger patient age (OR 0.70 per decade, 95% CI 0.61–0.79) and female gender (OR 2.23; 95% CI 1.55–3.22) to be the strongest independent predictors of a worse VAQ score. Scores were also significantly more likely to be worse in those with a history of cardiac disease (OR 1.69; 95% CI 1.13–2.52) and those requiring radiological interventions in the previous year (OR 1.75; 95% CI 1.16–2.63), and to vary significantly across the units (largest OR 6.12; CI 1.91–19.62). However, after accounting for these mode of current access was not found to be a significant independent predictor of VAQ scores (p = 0.767).
Table 5
Multivariable analysis of VAQ scores
 
OR (95% CI)
p-Value
Age (per Decade)
0.70 (0.61–0.79)
<0.001
Gender (Female)
2.23 (1.55–3.22)
<0.001
Ethnicity
 
0.168
White
Asian
0.74 (0.44–1.25)
0.262
Black
1.39 (0.80–2.42)
0.246
Mixed
1.29 (0.09–18.16)
0.849
Peripheral Vascular Disease
1.44 (0.87–2.39)
0.158
Cardiac disease
1.69 (1.13–2.52)
0.010
Diabetes
 
0.482
No
Diet Controlled
0.59 (0.28–1.24)
0.162
Tablet Controlled
0.68 (0.27–1.70)
0.408
Insulin
0.95 (0.61–1.49)
0.829
Unit
 
0.026
Unit 1
Unit 2
1.82 (0.57–5.81)
0.313
Unit 3
2.08 (0.65–6.69)
0.218
Unit 4
2.95 (0.92–9.50)
0.069
Unit 5
2.92 (0.92–9.25)
0.069
Unit 6
1.97 (0.57–6.83)
0.285
Unit 7
2.31 (0.73–7.33)
0.154
Unit 8
3.60 (1.15–11.28)
0.028
Unit 9
4.96 (1.53–16.11)
0.008
Unit 10
6.12 (1.91–19.62)
0.002
Duration of Haemodialysis (per Year)
1.02 (0.98–1.06)
0.390
Current Access
 
0.767
AVF
AV graft
1.38 (0.58–3.25)
0.467
Tunnelled CVC
1.03 (0.62–1.71)
0.901
Duration of Current Access
 
0.124
<1 month
2.71 (0.93–7.88)
0.067
1 month - 6 months
1.25 (0.70–2.26)
0.450
6 months − 12 months
1.66 (0.97–2.87)
0.066
over 1 year
Radiology Intervention in the Last Year
1.75 (1.16–2.63)
0.007
Number of Previous CVC
 
0.474
0
1 to 5
0.93 (0.60–1.42)
0.725
6 to 10
1.63 (0.72–3.67)
0.239
>10
0.89 (0.28–2.87)
0.847
Results are from a multivariable binary logistic regression model, with a VAQ score > 7 as the dependent variable. The N = 2 patients with both CVCs and AVF were excluded, as were N = 4 with missing data on one of the factors, leaving N = 743 (N = 196 outcomes) for analysis. Odds ratios are relative to the reference category, or are for an increase of the stated number of units for continuous variables. Bold p-values are significant at p < 0.05

Components of the VAQ score

The VAQ score was broken down into its component questions, and analysed. The components with the best average scores were: infection and redness, with means of 0.05 and 0.07 respectively (Fig. 1). The worst average scores were for problems sleeping and worries over how long the access would last, having an average of 0.66 and 0.64 respectively.
The average scores for each question were compared across a range of demographic and access-related factors (Tables 6 and 7). The overall VAQ score had been shown to improve significantly with patient age. No significant associations were detected between patient age and the majority of the symptom-related questions. Scores for clotting were found to improve significantly with age (p < 0.001). Appearance became significantly less important with age, declining from a mean of 0.63 in < 55 years, to 0.23 in those aged 75+ (p < 0.001). Infection scores improved with increasing age, from a mean of 0.10 in the < 55 to 0.02 in the 75+ (p = 0.050).
Table 6
Comparisons of VAQ score components by demographic and access-related factors (part 1)
 
Mean Score for the VAQ Question Relating to:
Bleeding
Pain
Bruising
Swelling
Redness
Infection
Clotting
Appearance
Age (Years)
p = 0.071
p = 0.283
p = 0.232
p = 0.921
p = 0.328
p = 0.050
p < 0.001
p < 0.001
<55
0.17
0.24
0.19
0.14
0.12
0.10
0.27
0.63
55–64
0.21
0.31
0.26
0.17
0.07
0.04
0.24
0.40
65–74
0.19
0.16
0.22
0.13
0.04
0.03
0.16
0.40
75+
0.27
0.20
0.24
0.14
0.06
0.02
0.06
0.23
Gender
p = 0.575
p = 0.006
p = 0.005
p = 0.907
p = 0.692
p = 0.874
p < 0.001
p < 0.001
Female
0.23
0.30
0.28
0.15
0.07
0.05
0.27
0.60
Male
0.20
0.17
0.19
0.14
0.07
0.04
0.11
0.26
Number of Previous CVC
p = 0.655
p = 0.129
p = 0.510
p = 0.949
p = 0.078
p = 0.122
p < 0.001
p = 0.868
0–5
0.22
0.21
0.23
0.14
0.06
0.03
0.15
0.40
6+
0.19
0.39
0.19
0.18
0.24
0.16
0.45
0.42
Current Mode of Vascular Access*
p < 0.001
p = 0.068
p < 0.001
p < 0.001
p < 0.001
p < 0.001
p = 0.008
p = 0.392
AVF
0.26
0.27
0.30
0.17
0.03
0.01
0.14
0.39
AV graft
0.24
0.18
0.21
0.29
0.00
0.06
0.32
0.21
Tunnelled CVC
0.06
0.12
0.02
0.06
0.21
0.17
0.26
0.46
Current Fistula**
p = 0.257
p = 0.080
p = 0.831
p = 0.975
p = 0.921
p = 0.593
p = 0.172
p = 0.288
Brachiobasilic
0.36
0.19
0.23
0.13
0.04
0.00
0.06
0.49
Brachiocephalic
0.32
0.33
0.33
0.18
0.03
0.00
0.17
0.44
Radiocephalic
0.17
0.19
0.29
0.15
0.03
0.01
0.14
0.33
Fistula/Graft on Dominant Arm**
p = 0.136
p = 0.410
p = 0.638
p = 0.730
p = 0.850
p = 0.358
p = 0.567
p = 0.634
No
0.25
0.27
0.28
0.17
0.03
0.01
0.16
0.41
Yes
0.28
0.23
0.34
0.15
0.02
0.00
0.14
0.33
Does Fistula/Graft on Dominant Arm Cause Issues**
p = 0.516
p = 0.045
p = 0.016
p = 0.599
p = 0.258
p = 1.000
p = 0.254
p = 0.001
No
0.28
0.14
0.22
0.16
0.03
0.00
0.10
0.20
Yes
0.27
0.46
0.65
0.14
0.00
0.00
0.22
0.62
p-Values are from Mann-Whitney or Kruskal-Wallis tests for comparisons across factors with two or three categories, respectively. For patient age, the exact value was correlated with the scores using Spearman’s rho. Bold p-values are significant at p < 0.05
*Excludes N = 2 patients with both CVC and AVF. **For patients where this question was applicable
Table 7
Comparisons of VAQ score components by demographic and access-related factors (part 2)
 
Mean Score for the VAQ Question Relating to:
Worries Working Well
Attending Dialysis Early
Leaving Dialysis Late
Problems Sleeping
Protecting Access
Interfering ADL’s
Interfering Leisure Activities
Worries About Hospitalisation
How Long Access Will Last
Age (Years)
p < 0.001
p = 0.149
p = 0.556
p < 0.001
p < 0.001
p < 0.001
p < 0.001
p = 0.003
p < 0.001
<55
0.71
0.28
0.51
0.90
0.94
0.55
0.57
0.50
0.85
55–64
0.60
0.26
0.42
0.74
0.63
0.29
0.26
0.53
0.80
65–74
0.44
0.28
0.43
0.60
0.40
0.25
0.20
0.41
0.56
75+
0.29
0.16
0.43
0.44
0.31
0.12
0.10
0.27
0.41
Gender
p = 0.116
p = 0.047
p = 0.037
p < 0.001
p = 0.214
p = 0.190
p = 0.520
p < 0.001
p = 0.004
Female
0.56
0.28
0.52
0.80
0.63
0.36
0.30
0.54
0.77
Male
0.45
0.21
0.39
0.56
0.50
0.25
0.25
0.33
0.56
Number of Previous CVC
p < 0.001
p = 0.413
p = 0.042
p = 0.035
p = 0.046
p = 0.089
p = 0.023
p < 0.001
p < 0.001
0–5
0.45
0.23
0.42
0.63
0.53
0.28
0.25
0.35
0.56
6+
1.03
0.34
0.72
0.93
0.87
0.46
0.48
1.10
1.48
Current Mode of Vascular Access*
p = 0.025
p = 0.370
p = 0.308
p = 0.635
p = 0.020
p < 0.001
p = 0.024
p < 0.001
p = 0.001
AVF
0.43
0.21
0.41
0.64
0.50
0.22
0.23
0.33
0.54
AV graft
0.82
0.29
0.76
0.88
0.65
0.24
0.21
0.74
1.12
Tunnelled CVC
0.62
0.33
0.50
0.66
0.73
0.53
0.41
0.64
0.85
Current Fistula**
p = 0.044
p = 0.988
p = 0.683
p = 0.032
p = 0.145
p = 0.217
p = 0.388
p = 0.467
p = 0.021
Brachiobasilic
0.58
0.17
0.36
0.98
0.48
0.13
0.15
0.46
0.87
Brachiocephalic
0.37
0.21
0.45
0.67
0.43
0.22
0.22
0.34
0.53
Radiocephalic
0.48
0.23
0.36
0.54
0.58
0.24
0.26
0.27
0.48
Fistula/Graft on Dominant Arm**
p = 0.936
p = 0.683
p = 0.957
p = 0.305
p = 0.621
p = 0.936
p = 0.303
p = 0.516
p = 0.556
No
0.44
0.22
0.42
0.64
0.51
0.23
0.22
0.35
0.55
Yes
0.48
0.19
0.43
0.78
0.44
0.20
0.27
0.31
0.64
Does Fistula/Graft on Dominant Arm Cause Issues**
p = 0.495
p = 0.063
p = 0.763
p = 0.801
p = 0.022
p < 0.001
p < 0.001
p = 0.937
p = 0.423
No
0.44
0.26
0.44
0.73
0.32
0.03
0.09
0.31
0.56
Yes
0.57
0.03
0.41
0.89
0.73
0.59
0.70
0.32
0.81
p-Values are from Mann-Whitney or Kruskal-Wallis tests for comparisons across factors with two or three categories, respectively. For patient age, the exact value was correlated with the scores using Spearman’s rho. Bold p-values are significant at p < 0.05
*Excludes N = 2 patients with both CVC and AVF. **For patients where this question was applicable
Worries about the access working well, lasting, being protected and about requiring hospitalisation all declined significantly with age. Older patients scored significantly lower (showing less impact of the access) on the questions about having trouble sleeping, and interference with activities of daily living (ADLs) and leisure activities. Scores for attending dialysis early and leaving late did not differ significantly with age.
Analysis by gender found that females had significantly worse scores for pain, bruising and clotting than males. Females also scored significantly worse on the questions relating to appearance, problems sleeping, and worries about hospitalisation and how long the access would last. Concerns about attending dialysis early and leaving late were also significantly higher in females than in males.
Patients with six or more previous CVC had significantly worse scores on the clotting concerns component, as well as for problems sleeping, protecting their access and interference with leisure activities. These patients also scored significantly worse with regards to worries that the treatment is working well, how long the access will last, and about hospitalisation than those with fewer previous CVCs.
Comparisons across the modes of vascular access demonstrated significant differences for bleeding, bruising and swelling, for which the lowest scores were in CVCs. Significant differences in redness and infection were found, both of which were highest scores in CVC. A significant difference in the clotting scores was also detected, which were found to be lowest in AVF. Worries about the access working well, being protected, how long it would last and about hospitalisation were found to differ significantly by type of access, with average scores consistently being lower in AVF. Significant differences in the interference in ADLs and leisure activities were also observed, with scores being highest in tunnelled CVC.
For the subgroup of patients with AVFs, significant differences across types were detected for the questions relating to problems sleeping, concerns about how well the fistula was working and worries about how long the AVF would last. The scores for these were worse in Brachiobasilic but better in Radiocephalic AVF.
Comparisons between AVF and grafts in the dominant vs. non-dominant arm found no significant differences for any of the components. However, within the subgroup of patients with an AVF or graft in the dominant arm, those reporting that this caused issues scored considerably higher on the questions relating to interference with ADLs and leisure activities. In addition, these patients also had significantly higher scores for bruising, appearance, pain and for protecting access.

Views on AVF vs. CVC by unit

Patients were asked which type of access they felt nurses preferred, and which they thought was best for their health. For the former, 36.3% of patients thought nurses preferred AVF and 9.5% responded with CVC, with 23.8% feeling that nurses were equally happy with two methods, and 30.4% being unsure. The majority of patients (73.9%) believed that AVF were better for their health, with 7.0% responding with CVC, 5.2% believing that there was no difference, and 13.9% unsure (Table 1).
These responses were then compared across the units. The responses of “Equal” or “Not Sure” were combined, and treated as a middle category, between CVC and AVF. Comparisons of the resulting variable found no significant differences in the responses to either question between units, with p = 0.318 and p = 0.115 respectively (Fig. 2).

Free text analysis

Respondents dialysing on a CVC were asked whether they would consider changing to an AVF. For those who replied “no”, their reason was sought and categorised (Table 8). The majority of reasons related to concerns about physical (visual) implications of a fistula (34%) or because they were “happy on the line” (25%).
Table 8
Free text analysis
Reason
N (%)
Reasons for not considering fistula if current access is a CVC (N = 67)
Concern about physical aspects of the fistula
 
Pain from the fistula
12 (18%)
Appearance of fistula
5 (7%)
Bleeding from the fistula
4 (6%)
Lifespan of a fistula
1 (1%)
Concerned about amount of maintenance required
1 (1%)
Happy on a line/ feels a line is better for health
17 (25%)
Concern about having surgery
10 (15%)
Previous bad experience with fistula
7 (10%)
Surgical fatigue
7 (10%)
Holding out for a transplant
3 (4%)
Problems from fistula on dominant arm (N = 37)
Poorer function of dominant hand overall
26 (70%)
Decreased function of dominant hand whilst on dialysis
10 (27%)
Pain
2 (5%)
Inability to self cannulate
1 (3%)
Is there anything else you wish you had known before starting? (N = 108a)
More information in general/medical aspects dialysis
28 (26%)
More information on access choices:
 
In general
13 (12%)
Covering CVC as an option
3 (3%)
More information about fistulas:
 
In general
4 (4%)
Bleeding risk
2 (2%)
Failure to mature risk
1 (1%)
Risk of steal
1 (1%)
Appearance
8 (7%)
More information on mechanisms of dialysis
 
Difficulty in needling
2 (2%)
Need for needle rotation
2 (2%)
Size of needles
1 (1%)
Pain relating to cannulation
10 (9%)
More information on renal replacement choices
11 (10%)
Information regarding impact of access on Activities daily living
7 (6%)
Crash landed so different info needed/discussed
6 (6%)
The amount of nephrology input would decrease on dialysis
3 (3%)
Discussion about the finite nature of vascular access options
2 (2%)
Need for intervention to maintain access
1 (1%)
Procedure for CVC removal
1 (1%)
More peer education
1 (1%)
Information on timing of access placement
1 (1%)
aAnalysis based on the 108 responses who did want more information
To ascertain whether the presence of an AVF on the dominant arm caused a problem, this sub-group of patients were identified and analysed. Of the 125 patients with fistulae on the dominant arm, 37 (29.6%) reported that this was a problem. Of these, the majority (70%) felt overall hand function was poorer in their dominant arm, whilst 27% reported decreased function of the dominant hand whilst on dialysis (Table 8).
As part of service evaluation and improvement, all participants were asked whether there was anything they wished they had known before starting on dialysis. One hundred eight patients identified areas where they would have benefited from further information (Table 8).

Discussion

Structured interviews has been shown to produce higher response rates and quality data capture than self-filled questionnaire studies and was hence employed [14, 15] and response rates were good with patients engaged in discussing their vascular access. Whilst only a comparatively small number of the population were not captured this must be acknowledged as a potential source of bias. Self-filled questionnaires have been suggested to provide freedom of thinking time and improve the accuracy of patient responses [16] however, we chose to replicate the method undertaken in the original VAQ and this could be identified as a potential weakness.
The VAQ was developed and validated in a Canadian haemodialysis population [12]. The VAQ indicated that patients are more satisfied with their access with increasing patient age and increasing age of their access; suggesting that there may be a period of adjustment whilst patients “get accustomed to” their access. This may be pertinent for counselling of patients prior to starting their access journey. For those patients who required intervention(s) to maintain their access, worse overall scores were seen. This may be lower levels of satisfaction, or could reflect the need for intervention heightening the patient’s awareness that the access may have a limited lifespan, increasing concern about future need for intervention.
Overall scores show better satisfaction with AVF than other modalities of access, although this was not found to be an independent predictive of satisfaction on multivariable analysis. When considering the components of the VAQ score separately, CVC’s showed greater impact on activities of daily living and leisure activities than other access modalities [5, 17]. As has been shown in other studies, the scores for the physical aspects (such as bleeding and appearance) of access were higher for AVFs, suggesting this maybe the reasoning behind the preference for CVCs [11, 17, 18].
From the multivariable analysis younger age and being female were both identified to give worse scores. These groups may be more conscious of their access and perceive its negative impact partly as a surrogate for the impact of their renal failure itself. As such a vital component of a patients ability to dialyse it may be that putting increased emphasis on these groups in the pre-dialysis counselling stages may be beneficial.
The presence of a fistula in the dominant arm did not seem to be of concern for the majority of patients. In those who did report issues, the VAQ score indicated that these largely related to appearance and interference with daily/leisure activities. Since vessel size in the dominant arm may be more favourable for fistula maturation, the longstanding dogma of avoiding the dominant arm should be challenged in selected patients, in favour of better vessel size [19].
Pain scores were not found to differ significantly between the different fistula types. Brachiobasilic fistulas have been suggested to be more painful (chronic pain and pain on cannulation) than brachiocephalic fistulas, but this has not been demonstrated in this cohort [20].
The VAQ differed significantly between dialysis units prompting further study to identify the causes and areas of the service in those units with the highest scores and least patient satisfaction to drive quality improvement. The difference between the scores in the units was not explained by different demographic differences between the units.
Differences, although not statistically significant, were identified between different dialysis units in terms of the patients perception of the nurse’s preference for dialysis access. Little research exists on the effect of the perception of the nurse’s preference on dialysis access modality choice, however, if patients feel that the nurses prefer CVCs then they might be more reluctant to consider changing from a CVC to a fistula. It also appears to be an area that would be sensible to target intervention and education towards.
Despite their access modality or preference, the majority of patients do seem to accept that fistulas are better for their health. However, despite this, the potential benefits do not outweigh the concerns about the physical aspects relating to the fistula. This is a finding that has been similarly highlighted in other research [11].

Conclusion

Overall, patients are satisfied with their access and are acutely aware of the critical role it plays in their renal disease management. The ability to measure modifiable factors such as nurse attitude and centre effect may allow a unique approach to application of quality improvement initiatives and their outcomes.

Acknowledgements

The authors would like to acknowledge the contribution to data collection of Mr. Kamlesh Patel and Mr. Dilan Dabare.
As this was an audit and quality improvement project ethical approval was not necessary only institutional approval, which was granted by Queen Elizabeth Hospital, University of Birmingham Foundation trust, Edgbaston, B15 2TH. (CARMS-12695). As is standard in our institution for audit purposes patients were verbally consented to participate. Consent to participate was recorded as participation in the audit data, patients who did not consent to participate in the audit were also recorded.
There is no patient identifiable data/images within the manuscript.

Competing interests

The authors have no conflicts or competing interests to declare and the results presented in this paper have not been published previously in whole or part, except in abstract format.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.

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Metadaten
Titel
The vascular access questionnaire: a single centre UK experience
verfasst von
M. Field
A.Z Khawaja
J. Ellis
T. Nieto
J. Hodson
N. Inston
Publikationsdatum
01.12.2019
Verlag
BioMed Central
Erschienen in
BMC Nephrology / Ausgabe 1/2019
Elektronische ISSN: 1471-2369
DOI
https://doi.org/10.1186/s12882-019-1493-9

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