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Erschienen in: European Archives of Oto-Rhino-Laryngology 3/2017

21.11.2016 | Otology

Therapeutic efficacy of azithromycin and acetylcysteine in chronic otitis media with effusion

verfasst von: Irena Babić, Tomislav Baudoin, Robert Trotić, Vladimir Bedeković

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 3/2017

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Abstract

Otitis media with effusion (OME) is a common disease in childhood. There is no consensus on the optimal therapeutic option for OME. Considering the known efficacy of acetylcysteine (AC) and azithromycin (AZ) in the treatment of middle ear mucosa, the aim of the study was to assess their efficacy in the management of chronic OME. The study included 90 children with OME, both ears. They are divided into three groups of 30 children. Group 1 (AC) patients were treated with acetylcysteine per os, 3 × 100 mg, for 3 weeks; group 2 (AZ) with body weight adjusted dose of azithromycin for 3 days; and group 3 (AC + AZ) with a combination of acetylcysteine and azithromycin at doses described above. Three measurements were performed. On second measurement, tympanogram improvement was recorded in 45% of 60 ears in group I, 53.3% of 60 ears in group II, and 61.7% of 60 ears in group III. The percentage of improvement was highest in group III. Although between-group differences did not reach statistical significance, the results obtained appear to be clinically relevant. In conclusion, conservative therapy for chronic OME is reasonable. Although study results don’t have a strong statistical differences and may not refer clinical improvement results suggest that this combination of drugs (antibiotics, bronchosecretolytics) can be useful in the treatment of OME.
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Metadaten
Titel
Therapeutic efficacy of azithromycin and acetylcysteine in chronic otitis media with effusion
verfasst von
Irena Babić
Tomislav Baudoin
Robert Trotić
Vladimir Bedeković
Publikationsdatum
21.11.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 3/2017
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-016-4389-3

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