Skip to main content
Erschienen in: Annals of Hematology 11/2003

01.11.2003 | Case Report

Therapy-related leukemia cutis: case study of an aggressive disorder

verfasst von: A. Zebisch, L. Cerroni, C. Beham-Schmid, H. Sill

Erschienen in: Annals of Hematology | Ausgabe 11/2003

Einloggen, um Zugang zu erhalten

Abstract

Therapy-related leukemia cutis has not yet been described. We report a 55-year-old male who developed aleukemic leukemia cutis 15 months after chemotherapy and radiotherapy for non-Hodgkin's lymphoma. Despite intensive therapy including allogeneic hematopoietic stem cell transplantation, the patient died of progressive disease. Sequence analysis of the TP53 gene and screening for defective DNA mismatch repair revealed no abnormalities. This case demonstrates that therapy-related aleukemic leukemia cutis is an aggressive disorder resistant to conventional antineoplastic treatment approaches. As the number of patients developing therapy-related myelodysplasia or leukemia is increasing, clinicians might be confronted more frequently with atypical, extramedullary presentations of these disorders.
Literatur
1.
Zurück zum Zitat Baer MR, Barcos M, Farrell H, Raza A, Preisler HD (1989) Acute myelogenous leukaemia with leukemia cutis. Cancer 63:2192–2200PubMed Baer MR, Barcos M, Farrell H, Raza A, Preisler HD (1989) Acute myelogenous leukaemia with leukemia cutis. Cancer 63:2192–2200PubMed
2.
Zurück zum Zitat Ben-Yehuda D, Krichevsky S, Caspi O, Rund D, Polliack A, Abeliovich D, Zelig O, Yahalom V, Paltiel O, Or R, Peretz T, Ben-Neriah S, Yehuda O, Rachmilewitz EA (1996) Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype. Blood 88:4296–4303PubMed Ben-Yehuda D, Krichevsky S, Caspi O, Rund D, Polliack A, Abeliovich D, Zelig O, Yahalom V, Paltiel O, Or R, Peretz T, Ben-Neriah S, Yehuda O, Rachmilewitz EA (1996) Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype. Blood 88:4296–4303PubMed
3.
Zurück zum Zitat Byrd JC, Edenfield WJ, Shields DJ, Dawson NA (1995) Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review. J Clin Oncol 13:1800–1816PubMed Byrd JC, Edenfield WJ, Shields DJ, Dawson NA (1995) Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review. J Clin Oncol 13:1800–1816PubMed
4.
Zurück zum Zitat Christiansen DH, Andersen MK, Pedersen-Bjergaard J (2001) Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis. J Clin Oncol 19:1405–1413PubMed Christiansen DH, Andersen MK, Pedersen-Bjergaard J (2001) Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis. J Clin Oncol 19:1405–1413PubMed
5.
Zurück zum Zitat Das-Gupta EP, Seedhouse CH, Russell NH (2001) Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia. Br J Haematol 114:307–312CrossRefPubMed Das-Gupta EP, Seedhouse CH, Russell NH (2001) Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia. Br J Haematol 114:307–312CrossRefPubMed
6.
Zurück zum Zitat Greenblatt MS, Benett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855–4878PubMed Greenblatt MS, Benett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855–4878PubMed
7.
Zurück zum Zitat Husak R, Blume-Peytaki U, Orfanos CE (1999) Aleukemic leukemia cutis in an adolescent boy. N Engl J Med 340:893–894CrossRefPubMed Husak R, Blume-Peytaki U, Orfanos CE (1999) Aleukemic leukemia cutis in an adolescent boy. N Engl J Med 340:893–894CrossRefPubMed
8.
Zurück zum Zitat Kaddu S, Zenahlik P, Beham-Schmid C, Kerl H, Cerroni L (1999) Specific cutaneous infiltrates in patients with myelogenous leukemia: a clinicopathologic study of 26 patients with assessment of diagnostic criteria. J Am Acad Dermatol 40:966–978PubMed Kaddu S, Zenahlik P, Beham-Schmid C, Kerl H, Cerroni L (1999) Specific cutaneous infiltrates in patients with myelogenous leukemia: a clinicopathologic study of 26 patients with assessment of diagnostic criteria. J Am Acad Dermatol 40:966–978PubMed
9.
Zurück zum Zitat Ohno S, Yokoo T, Ohta M, Yamamoto M, Danno K, Hamato N, Tomii K, Ohno Y, Kobashi Y (1990) Aleukemic leukemia cutis. J Am Acad Dermatol 22:374–377PubMed Ohno S, Yokoo T, Ohta M, Yamamoto M, Danno K, Hamato N, Tomii K, Ohno Y, Kobashi Y (1990) Aleukemic leukemia cutis. J Am Acad Dermatol 22:374–377PubMed
10.
Zurück zum Zitat Olipitz W, Hopfinger G, Aguiar RCT, Gunsilius E, Girschikofsky M, Bodner C, Hiden K, Linkesch W, Hoefler G, Sill H (2002) Defective DNA-mismatch repair: a potential mediator of leukemogenic susceptibility in therapy-related myelodysplasia and leukemia. Genes Chromosomes Cancer 34:243–248CrossRefPubMed Olipitz W, Hopfinger G, Aguiar RCT, Gunsilius E, Girschikofsky M, Bodner C, Hiden K, Linkesch W, Hoefler G, Sill H (2002) Defective DNA-mismatch repair: a potential mediator of leukemogenic susceptibility in therapy-related myelodysplasia and leukemia. Genes Chromosomes Cancer 34:243–248CrossRefPubMed
11.
Zurück zum Zitat Pedersen-Bjergaard J, Andersen MK, Christiansen DH, Nerlov C (2002) Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. Blood 99:1909–1912CrossRefPubMed Pedersen-Bjergaard J, Andersen MK, Christiansen DH, Nerlov C (2002) Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. Blood 99:1909–1912CrossRefPubMed
12.
Zurück zum Zitat Shaikh BS, Frantz E, Lookingbill DP (1987) Histologically proven leukemia cutis carries a poor prognosis in acute nonlymphocytic leukemia. Cutis 39:57–60PubMed Shaikh BS, Frantz E, Lookingbill DP (1987) Histologically proven leukemia cutis carries a poor prognosis in acute nonlymphocytic leukemia. Cutis 39:57–60PubMed
13.
Zurück zum Zitat Smith SM, Le Beau MM, Huo D, Karrison T, Sobecks RM, Anastasi J, Vardiman JW, Rowley JD, Larson RA (2003) Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood 102:43–52CrossRefPubMed Smith SM, Le Beau MM, Huo D, Karrison T, Sobecks RM, Anastasi J, Vardiman JW, Rowley JD, Larson RA (2003) Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood 102:43–52CrossRefPubMed
Metadaten
Titel
Therapy-related leukemia cutis: case study of an aggressive disorder
verfasst von
A. Zebisch
L. Cerroni
C. Beham-Schmid
H. Sill
Publikationsdatum
01.11.2003
Verlag
Springer-Verlag
Erschienen in
Annals of Hematology / Ausgabe 11/2003
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-003-0717-y

Weitere Artikel der Ausgabe 11/2003

Annals of Hematology 11/2003 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.