Skip to main content
Erschienen in: NeuroMolecular Medicine 2/2018

23.03.2018 | Review Paper

Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway–PPAR Gamma, Energy Metabolism and Circadian Rhythms

verfasst von: Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée

Erschienen in: NeuroMolecular Medicine | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

Entropy production rate is increased by several metabolic and thermodynamics abnormalities in neurodegenerative diseases (NDs). Irreversible processes are quantified by changes in the entropy production rate. This review is focused on the opposing interactions observed in NDs between the canonical WNT/beta-catenin pathway and PPAR gamma and their metabolic and thermodynamic implications. In amyotrophic lateral sclerosis and Huntington’s disease, WNT/beta-catenin pathway is upregulated, whereas PPAR gamma is downregulated. In Alzheimer’s disease and Parkinson’s disease, WNT/beta-catenin pathway is downregulated while PPAR gamma is upregulated. The dysregulation of the canonical WNT/beta-catenin pathway is responsible for the modification of thermodynamics behaviors of metabolic enzymes. Upregulation of WNT/beta-catenin pathway leads to aerobic glycolysis, named Warburg effect, through activated enzymes, such as glucose transporter (Glut), pyruvate kinase M2 (PKM2), pyruvate dehydrogenase kinase 1(PDK1), monocarboxylate lactate transporter 1 (MCT-1), lactic dehydrogenase kinase-A (LDH-A) and inactivation of pyruvate dehydrogenase complex (PDH). Downregulation of WNT/beta-catenin pathway leads to oxidative stress and cell death through inactivation of Glut, PKM2, PDK1, MCT-1, LDH-A but activation of PDH. In addition, in NDs, PPAR gamma is dysregulated, whereas it contributes to the regulation of several key circadian genes. NDs show many dysregulation in the mediation of circadian clock genes and so of circadian rhythms. Thermodynamics rhythms operate far-from-equilibrium and partly regulate interactions between WNT/beta-catenin pathway and PPAR gamma. In NDs, metabolism, thermodynamics and circadian rhythms are tightly interrelated.
Literatur
Zurück zum Zitat Abe, M., Herzog, E. D., Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., et al. (2002). Circadian rhythms in isolated brain regions. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 22(1), 350–356.CrossRef Abe, M., Herzog, E. D., Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., et al. (2002). Circadian rhythms in isolated brain regions. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 22(1), 350–356.CrossRef
Zurück zum Zitat Aliev, G., Priyadarshini, M., Reddy, V. P., Grieg, N. H., Kaminsky, Y., Cacabelos, R., et al. (2014). Oxidative stress mediated mitochondrial and vascular lesions as markers in the pathogenesis of Alzheimer disease. Current Medicinal Chemistry, 21(19), 2208–2217.PubMedCrossRef Aliev, G., Priyadarshini, M., Reddy, V. P., Grieg, N. H., Kaminsky, Y., Cacabelos, R., et al. (2014). Oxidative stress mediated mitochondrial and vascular lesions as markers in the pathogenesis of Alzheimer disease. Current Medicinal Chemistry, 21(19), 2208–2217.PubMedCrossRef
Zurück zum Zitat Bonuccelli, U., Del Dotto, P., Lucetti, C., Petrozzi, L., Bernardini, S., Gambaccini, G., et al. (2000). Diurnal motor variations to repeated doses of levodopa in Parkinson’s disease. Clinical Neuropharmacology, 23(1), 28–33.PubMedCrossRef Bonuccelli, U., Del Dotto, P., Lucetti, C., Petrozzi, L., Bernardini, S., Gambaccini, G., et al. (2000). Diurnal motor variations to repeated doses of levodopa in Parkinson’s disease. Clinical Neuropharmacology, 23(1), 28–33.PubMedCrossRef
Zurück zum Zitat Borghammer, P. (2012). Perfusion and metabolism imaging studies in Parkinson’s disease. Danish Medical Journal, 59(6), B4466.PubMed Borghammer, P. (2012). Perfusion and metabolism imaging studies in Parkinson’s disease. Danish Medical Journal, 59(6), B4466.PubMed
Zurück zum Zitat Borghammer, P., Chakravarty, M., Jonsdottir, K. Y., Sato, N., Matsuda, H., Ito, K., et al. (2010). Cortical hypometabolism and hypoperfusion in Parkinson’s disease is extensive: Probably even at early disease stages. Brain Structure & Function, 214(4), 303–317. https://doi.org/10.1007/s00429-010-0246-0.CrossRef Borghammer, P., Chakravarty, M., Jonsdottir, K. Y., Sato, N., Matsuda, H., Ito, K., et al. (2010). Cortical hypometabolism and hypoperfusion in Parkinson’s disease is extensive: Probably even at early disease stages. Brain Structure & Function, 214(4), 303–317. https://​doi.​org/​10.​1007/​s00429-010-0246-0.CrossRef
Zurück zum Zitat Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., et al. (2000). Mop3 is an essential component of the master circadian pacemaker in mammals. Cell, 103(7), 1009–1017.PubMedPubMedCentralCrossRef Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., et al. (2000). Mop3 is an essential component of the master circadian pacemaker in mammals. Cell, 103(7), 1009–1017.PubMedPubMedCentralCrossRef
Zurück zum Zitat Chiang, M.-C., Chen, C.-M., Lee, M.-R., Chen, H.-W., Chen, H.-M., Wu, Y.-S., et al. (2010). Modulation of energy deficiency in Huntington’s disease via activation of the peroxisome proliferator-activated receptor gamma. Human Molecular Genetics, 19(20), 4043–4058. https://doi.org/10.1093/hmg/ddq322.PubMedCrossRef Chiang, M.-C., Chen, C.-M., Lee, M.-R., Chen, H.-W., Chen, H.-M., Wu, Y.-S., et al. (2010). Modulation of energy deficiency in Huntington’s disease via activation of the peroxisome proliferator-activated receptor gamma. Human Molecular Genetics, 19(20), 4043–4058. https://​doi.​org/​10.​1093/​hmg/​ddq322.PubMedCrossRef
Zurück zum Zitat Chuquet, J., Quilichini, P., Nimchinsky, E. A., & Buzsáki, G. (2010). Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30(45), 15298–15303. https://doi.org/10.1523/jneurosci.0762-10.2010.CrossRef Chuquet, J., Quilichini, P., Nimchinsky, E. A., & Buzsáki, G. (2010). Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30(45), 15298–15303. https://​doi.​org/​10.​1523/​jneurosci.​0762-10.​2010.CrossRef
Zurück zum Zitat Combs, C. K., Johnson, D. E., Karlo, J. C., Cannady, S. B., & Landreth, G. E. (2000). Inflammatory mechanisms in Alzheimer’s disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 20(2), 558–567.CrossRef Combs, C. K., Johnson, D. E., Karlo, J. C., Cannady, S. B., & Landreth, G. E. (2000). Inflammatory mechanisms in Alzheimer’s disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 20(2), 558–567.CrossRef
Zurück zum Zitat Csernus, V., & Mess, B. (2003). Biorhythms and pineal gland. Neuro Endocrinology Letters, 24(6), 404–411.PubMed Csernus, V., & Mess, B. (2003). Biorhythms and pineal gland. Neuro Endocrinology Letters, 24(6), 404–411.PubMed
Zurück zum Zitat Cuadrado-Tejedor, M., Vilariño, M., Cabodevilla, F., Del Río, J., Frechilla, D., & Pérez-Mediavilla, A. (2011). Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer’s disease transgenic mice: An insight into the pathogenic effects of amyloid-β. Journal of Alzheimer’s disease: JAD, 23(2), 195–206. https://doi.org/10.3233/jad-2010-100966.PubMedCrossRef Cuadrado-Tejedor, M., Vilariño, M., Cabodevilla, F., Del Río, J., Frechilla, D., & Pérez-Mediavilla, A. (2011). Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer’s disease transgenic mice: An insight into the pathogenic effects of amyloid-β. Journal of Alzheimer’s disease: JAD, 23(2), 195–206. https://​doi.​org/​10.​3233/​jad-2010-100966.PubMedCrossRef
Zurück zum Zitat Czeisler, C. A., Dumont, M., Duffy, J. F., Steinberg, J. D., Richardson, G. S., Brown, E. N., et al. (1992). Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet (London, England), 340(8825), 933–936.CrossRef Czeisler, C. A., Dumont, M., Duffy, J. F., Steinberg, J. D., Richardson, G. S., Brown, E. N., et al. (1992). Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet (London, England), 340(8825), 933–936.CrossRef
Zurück zum Zitat de la Monte, S. M., & Wands, J. R. (2006). Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer’s disease. Journal of Alzheimer’s disease: JAD, 9(2), 167–181.PubMedCrossRef de la Monte, S. M., & Wands, J. R. (2006). Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer’s disease. Journal of Alzheimer’s disease: JAD, 9(2), 167–181.PubMedCrossRef
Zurück zum Zitat Djouadi, F., Lecarpentier, Y., Hébert, J.-L., Charron, P., Bastin, J., & Coirault, C. (2009). A potential link between peroxisome proliferator-activated receptor signalling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy. Cardiovascular Research, 84(1), 83–90. https://doi.org/10.1093/cvr/cvp183.PubMedCrossRef Djouadi, F., Lecarpentier, Y., Hébert, J.-L., Charron, P., Bastin, J., & Coirault, C. (2009). A potential link between peroxisome proliferator-activated receptor signalling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy. Cardiovascular Research, 84(1), 83–90. https://​doi.​org/​10.​1093/​cvr/​cvp183.PubMedCrossRef
Zurück zum Zitat Duffield, G. E., Best, J. D., Meurers, B. H., Bittner, A., Loros, J. J., & Dunlap, J. C. (2002). Circadian programs of transcriptional activation, signaling, and protein turnover revealed by microarray analysis of mammalian cells. Current biology: CB, 12(7), 551–557.PubMedCrossRef Duffield, G. E., Best, J. D., Meurers, B. H., Bittner, A., Loros, J. J., & Dunlap, J. C. (2002). Circadian programs of transcriptional activation, signaling, and protein turnover revealed by microarray analysis of mammalian cells. Current biology: CB, 12(7), 551–557.PubMedCrossRef
Zurück zum Zitat Edison, P., Ahmed, I., Fan, Z., Hinz, R., Gelosa, G., Ray Chaudhuri, K., et al. (2013). Microglia, amyloid, and glucose metabolism in Parkinson’s disease with and without dementia. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 38(6), 938–949. https://doi.org/10.1038/npp.2012.255.CrossRef Edison, P., Ahmed, I., Fan, Z., Hinz, R., Gelosa, G., Ray Chaudhuri, K., et al. (2013). Microglia, amyloid, and glucose metabolism in Parkinson’s disease with and without dementia. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 38(6), 938–949. https://​doi.​org/​10.​1038/​npp.​2012.​255.CrossRef
Zurück zum Zitat Elbrecht, A., Chen, Y., Cullinan, C. A., Hayes, N., Leibowitz, M. D., Moller, D. E., et al. (1996). Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2. Biochemical and Biophysical Research Communications, 224(2), 431–437.PubMedCrossRef Elbrecht, A., Chen, Y., Cullinan, C. A., Hayes, N., Leibowitz, M. D., Moller, D. E., et al. (1996). Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2. Biochemical and Biophysical Research Communications, 224(2), 431–437.PubMedCrossRef
Zurück zum Zitat El-Sahar, A. E., Safar, M. M., Zaki, H. F., Attia, A. S., & Ain-Shoka, A. A. (2015). Neuroprotective effects of pioglitazone against transient cerebral ischemic reperfusion injury in diabetic rats: Modulation of antioxidant, anti-inflammatory, and anti-apoptotic biomarkers. Pharmacological reports: PR, 67(5), 901–906. https://doi.org/10.1016/j.pharep.2015.03.018.PubMedCrossRef El-Sahar, A. E., Safar, M. M., Zaki, H. F., Attia, A. S., & Ain-Shoka, A. A. (2015). Neuroprotective effects of pioglitazone against transient cerebral ischemic reperfusion injury in diabetic rats: Modulation of antioxidant, anti-inflammatory, and anti-apoptotic biomarkers. Pharmacological reports: PR, 67(5), 901–906. https://​doi.​org/​10.​1016/​j.​pharep.​2015.​03.​018.PubMedCrossRef
Zurück zum Zitat Escribano, L., Simón, A.-M., Gimeno, E., Cuadrado-Tejedor, M., López de Maturana, R., García-Osta, A., et al. (2010). Rosiglitazone rescues memory impairment in Alzheimer’s transgenic mice: Mechanisms involving a reduced amyloid and tau pathology. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 35(7), 1593–1604. https://doi.org/10.1038/npp.2010.32.CrossRef Escribano, L., Simón, A.-M., Gimeno, E., Cuadrado-Tejedor, M., López de Maturana, R., García-Osta, A., et al. (2010). Rosiglitazone rescues memory impairment in Alzheimer’s transgenic mice: Mechanisms involving a reduced amyloid and tau pathology. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 35(7), 1593–1604. https://​doi.​org/​10.​1038/​npp.​2010.​32.CrossRef
Zurück zum Zitat Fajas, L., Auboeuf, D., Raspé, E., Schoonjans, K., Lefebvre, A. M., Saladin, R., et al. (1997). The organization, promoter analysis, and expression of the human PPARgamma gene. The Journal of biological Chemistry, 272(30), 18779–18789.PubMedCrossRef Fajas, L., Auboeuf, D., Raspé, E., Schoonjans, K., Lefebvre, A. M., Saladin, R., et al. (1997). The organization, promoter analysis, and expression of the human PPARgamma gene. The Journal of biological Chemistry, 272(30), 18779–18789.PubMedCrossRef
Zurück zum Zitat Fontaine, C., Dubois, G., Duguay, Y., Helledie, T., Vu-Dac, N., Gervois, P., et al. (2003). The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation. The Journal of biological chemistry, 278(39), 37672–37680. https://doi.org/10.1074/jbc.m304664200.PubMedCrossRef Fontaine, C., Dubois, G., Duguay, Y., Helledie, T., Vu-Dac, N., Gervois, P., et al. (2003). The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation. The Journal of biological chemistry, 278(39), 37672–37680. https://​doi.​org/​10.​1074/​jbc.​m304664200.PubMedCrossRef
Zurück zum Zitat Fuenzalida, K., Quintanilla, R., Ramos, P., Piderit, D., Fuentealba, R. A., Martinez, G., et al. (2007). Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. The Journal of biological chemistry, 282(51), 37006–37015. https://doi.org/10.1074/jbc.m700447200.PubMedCrossRef Fuenzalida, K., Quintanilla, R., Ramos, P., Piderit, D., Fuentealba, R. A., Martinez, G., et al. (2007). Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. The Journal of biological chemistry, 282(51), 37006–37015. https://​doi.​org/​10.​1074/​jbc.​m700447200.PubMedCrossRef
Zurück zum Zitat Galea, E., Heneka, M. T., Dello Russo, C., & Feinstein, D. L. (2003). Intrinsic regulation of brain inflammatory responses. Cellular and Molecular Neurobiology, 23(4–5), 625–635.PubMedCrossRef Galea, E., Heneka, M. T., Dello Russo, C., & Feinstein, D. L. (2003). Intrinsic regulation of brain inflammatory responses. Cellular and Molecular Neurobiology, 23(4–5), 625–635.PubMedCrossRef
Zurück zum Zitat García-Bueno, B., Caso, J. R., Pérez-Nievas, B. G., Lorenzo, P., & Leza, J. C. (2007). Effects of peroxisome proliferator-activated receptor gamma agonists on brain glucose and glutamate transporters after stress in rats. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 32(6), 1251–1260. https://doi.org/10.1038/sj.npp.1301252.CrossRef García-Bueno, B., Caso, J. R., Pérez-Nievas, B. G., Lorenzo, P., & Leza, J. C. (2007). Effects of peroxisome proliferator-activated receptor gamma agonists on brain glucose and glutamate transporters after stress in rats. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 32(6), 1251–1260. https://​doi.​org/​10.​1038/​sj.​npp.​1301252.CrossRef
Zurück zum Zitat García-Bueno, B., Madrigal, J. L. M., Lizasoain, I., Moro, M. A., Lorenzo, P., & Leza, J. C. (2005). The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. Psychopharmacology (Berl), 180(3), 513–522. https://doi.org/10.1007/s00213-005-2195-5.CrossRef García-Bueno, B., Madrigal, J. L. M., Lizasoain, I., Moro, M. A., Lorenzo, P., & Leza, J. C. (2005). The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. Psychopharmacology (Berl), 180(3), 513–522. https://​doi.​org/​10.​1007/​s00213-005-2195-5.CrossRef
Zurück zum Zitat Garcia-Gras, E., Lombardi, R., Giocondo, M. J., Willerson, J. T., Schneider, M. D., Khoury, D. S., et al. (2006). Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. The Journal of Clinical Investigation, 116(7), 2012–2021. https://doi.org/10.1172/jci27751.PubMedPubMedCentralCrossRef Garcia-Gras, E., Lombardi, R., Giocondo, M. J., Willerson, J. T., Schneider, M. D., Khoury, D. S., et al. (2006). Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. The Journal of Clinical Investigation, 116(7), 2012–2021. https://​doi.​org/​10.​1172/​jci27751.PubMedPubMedCentralCrossRef
Zurück zum Zitat Gargiulo-Monachelli, G. M., Sivori, M., Meyer, M., Sica, R. E. P., De Nicola, A. F., & Gonzalez-Deniselle, M. C. (2014). Circulating gonadal and adrenal steroids in amyotrophic lateral sclerosis: Possible markers of susceptibility and outcome. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 46(6), 433–439. https://doi.org/10.1055/s-0034-1371891.PubMedCrossRef Gargiulo-Monachelli, G. M., Sivori, M., Meyer, M., Sica, R. E. P., De Nicola, A. F., & Gonzalez-Deniselle, M. C. (2014). Circulating gonadal and adrenal steroids in amyotrophic lateral sclerosis: Possible markers of susceptibility and outcome. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 46(6), 433–439. https://​doi.​org/​10.​1055/​s-0034-1371891.PubMedCrossRef
Zurück zum Zitat Gekakis, N., Staknis, D., Nguyen, H. B., Davis, F. C., Wilsbacher, L. D., King, D. P., et al. (1998). Role of the CLOCK protein in the mammalian circadian mechanism. Science (New York, N.Y.), 280(5369), 1564–1569.CrossRef Gekakis, N., Staknis, D., Nguyen, H. B., Davis, F. C., Wilsbacher, L. D., King, D. P., et al. (1998). Role of the CLOCK protein in the mammalian circadian mechanism. Science (New York, N.Y.), 280(5369), 1564–1569.CrossRef
Zurück zum Zitat Gines, S., Ivanova, E., Seong, I.-S., Saura, C. A., & MacDonald, M. E. (2003). Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington’s disease knock-in striatal cells. The Journal of biological chemistry, 278(50), 50514–50522. https://doi.org/10.1074/jbc.m309348200.PubMedCrossRef Gines, S., Ivanova, E., Seong, I.-S., Saura, C. A., & MacDonald, M. E. (2003). Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington’s disease knock-in striatal cells. The Journal of biological chemistry, 278(50), 50514–50522. https://​doi.​org/​10.​1074/​jbc.​m309348200.PubMedCrossRef
Zurück zum Zitat Goldbeter, A. (1973). Patterns of spatiotemporal organization in an allosteric enzyme model. Proceedings of the National Academy of Sciences of the United States of America, 70(11), 3255–3259.PubMedPubMedCentralCrossRef Goldbeter, A. (1973). Patterns of spatiotemporal organization in an allosteric enzyme model. Proceedings of the National Academy of Sciences of the United States of America, 70(11), 3255–3259.PubMedPubMedCentralCrossRef
Zurück zum Zitat Goodwin, B. C. (1965). Oscillatory behavior in enzymatic control processes. Advances in Enzyme Regulation, 3, 425–438.PubMedCrossRef Goodwin, B. C. (1965). Oscillatory behavior in enzymatic control processes. Advances in Enzyme Regulation, 3, 425–438.PubMedCrossRef
Zurück zum Zitat Gravotta, L., Gavrila, A. M., Hood, S., & Amir, S. (2011). Global depletion of dopamine using intracerebroventricular 6-hydroxydopamine injection disrupts normal circadian wheel-running patterns and PERIOD2 expression in the rat forebrain. Journal of molecular neuroscience: MN, 45(2), 162–171. https://doi.org/10.1007/s12031-011-9520-8.PubMedCrossRef Gravotta, L., Gavrila, A. M., Hood, S., & Amir, S. (2011). Global depletion of dopamine using intracerebroventricular 6-hydroxydopamine injection disrupts normal circadian wheel-running patterns and PERIOD2 expression in the rat forebrain. Journal of molecular neuroscience: MN, 45(2), 162–171. https://​doi.​org/​10.​1007/​s12031-011-9520-8.PubMedCrossRef
Zurück zum Zitat Guo, B., Chatterjee, S., Li, L., Kim, J. M., Lee, J., Yechoor, V. K., et al. (2012). The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB Journal: official Publication of the Federation of American Societies for Experimental Biology, 26(8), 3453–3463. https://doi.org/10.1096/fj.12-205781.CrossRef Guo, B., Chatterjee, S., Li, L., Kim, J. M., Lee, J., Yechoor, V. K., et al. (2012). The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB Journal: official Publication of the Federation of American Societies for Experimental Biology, 26(8), 3453–3463. https://​doi.​org/​10.​1096/​fj.​12-205781.CrossRef
Zurück zum Zitat Guven, C., Taskin, E., & Akcakaya, H. (2016). Melatonin prevents mitochondrial damage induced by doxorubicin in mouse fibroblasts through AMPK-PPAR gamma-dependent mechanisms. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 22, 438–446.CrossRef Guven, C., Taskin, E., & Akcakaya, H. (2016). Melatonin prevents mitochondrial damage induced by doxorubicin in mouse fibroblasts through AMPK-PPAR gamma-dependent mechanisms. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 22, 438–446.CrossRef
Zurück zum Zitat Hatfield, C. F., Herbert, J., van Someren, E. J. W., Hodges, J. R., & Hastings, M. H. (2004). Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer’s dementia. Brain: A Journal of Neurology, 127, 1061–1074. https://doi.org/10.1093/brain/awh129.CrossRef Hatfield, C. F., Herbert, J., van Someren, E. J. W., Hodges, J. R., & Hastings, M. H. (2004). Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer’s dementia. Brain: A Journal of Neurology, 127, 1061–1074. https://​doi.​org/​10.​1093/​brain/​awh129.CrossRef
Zurück zum Zitat He, T. C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., et al. (1998). Identification of c-MYC as a target of the APC pathway. Science (New York, N.Y.), 281(5382), 1509–1512.CrossRef He, T. C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., et al. (1998). Identification of c-MYC as a target of the APC pathway. Science (New York, N.Y.), 281(5382), 1509–1512.CrossRef
Zurück zum Zitat Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009). The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nature Cell Biology, 11(6), 747–752. https://doi.org/10.1038/ncb1881.PubMedCrossRef Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009). The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nature Cell Biology, 11(6), 747–752. https://​doi.​org/​10.​1038/​ncb1881.PubMedCrossRef
Zurück zum Zitat Hofman, M. A. (2000). The human circadian clock and aging. Chronobiology International, 17(3), 245–259.PubMedCrossRef Hofman, M. A. (2000). The human circadian clock and aging. Chronobiology International, 17(3), 245–259.PubMedCrossRef
Zurück zum Zitat Hogenesch, J. B., Gu, Y. Z., Jain, S., & Bradfield, C. A. (1998). The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proceedings of the National Academy of Sciences of the United States of America, 95(10), 5474–5479.PubMedPubMedCentralCrossRef Hogenesch, J. B., Gu, Y. Z., Jain, S., & Bradfield, C. A. (1998). The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proceedings of the National Academy of Sciences of the United States of America, 95(10), 5474–5479.PubMedPubMedCentralCrossRef
Zurück zum Zitat Hood, S., Cassidy, P., Cossette, M.-P., Weigl, Y., Verwey, M., Robinson, B., et al. (2010). Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum via daily activation of D2 dopamine receptors. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30(42), 14046–14058. https://doi.org/10.1523/jneurosci.2128-10.2010.CrossRef Hood, S., Cassidy, P., Cossette, M.-P., Weigl, Y., Verwey, M., Robinson, B., et al. (2010). Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum via daily activation of D2 dopamine receptors. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30(42), 14046–14058. https://​doi.​org/​10.​1523/​jneurosci.​2128-10.​2010.CrossRef
Zurück zum Zitat Hult, S., Schultz, K., Soylu, R., & Petersén, A. (2010). Hypothalamic and neuroendocrine changes in Huntington’s disease. Current Drug Targets, 11(10), 1237–1249.PubMedCrossRef Hult, S., Schultz, K., Soylu, R., & Petersén, A. (2010). Hypothalamic and neuroendocrine changes in Huntington’s disease. Current Drug Targets, 11(10), 1237–1249.PubMedCrossRef
Zurück zum Zitat Humbert, S., Bryson, E. A., Cordelières, F. P., Connors, N. C., Datta, S. R., Finkbeiner, S., et al. (2002). The IGF-1/Akt pathway is neuroprotective in Huntington’s disease and involves Huntingtin phosphorylation by Akt. Developmental Cell, 2(6), 831–837.PubMedCrossRef Humbert, S., Bryson, E. A., Cordelières, F. P., Connors, N. C., Datta, S. R., Finkbeiner, S., et al. (2002). The IGF-1/Akt pathway is neuroprotective in Huntington’s disease and involves Huntingtin phosphorylation by Akt. Developmental Cell, 2(6), 831–837.PubMedCrossRef
Zurück zum Zitat Jakoby, P., Schmidt, E., Ruminot, I., Gutiérrez, R., Barros, L. F., & Deitmer, J. W. (2014). Higher transport and metabolism of glucose in astrocytes compared with neurons: A multiphoton study of hippocampal and cerebellar tissue slices. Cerebral Cortex (New York, N.Y.: 1991), 24(1), 222–231. https://doi.org/10.1093/cercor/bhs309.CrossRef Jakoby, P., Schmidt, E., Ruminot, I., Gutiérrez, R., Barros, L. F., & Deitmer, J. W. (2014). Higher transport and metabolism of glucose in astrocytes compared with neurons: A multiphoton study of hippocampal and cerebellar tissue slices. Cerebral Cortex (New York, N.Y.: 1991), 24(1), 222–231. https://​doi.​org/​10.​1093/​cercor/​bhs309.CrossRef
Zurück zum Zitat Joshi, P. R., Wu, N.-P., André, V. M., Cummings, D. M., Cepeda, C., Joyce, J. A., et al. (2009). Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 29(8), 2414–2427. https://doi.org/10.1523/jneurosci.5687-08.2009.CrossRef Joshi, P. R., Wu, N.-P., André, V. M., Cummings, D. M., Cepeda, C., Joyce, J. A., et al. (2009). Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 29(8), 2414–2427. https://​doi.​org/​10.​1523/​jneurosci.​5687-08.​2009.CrossRef
Zurück zum Zitat Kalliolia, E., Silajdžić, E., Nambron, R., Hill, N. R., Doshi, A., Frost, C., et al. (2014). Plasma melatonin is reduced in Huntington’s disease. Movement Disorders: Official Journal of the Movement Disorder Society, 29(12), 1511–1515. https://doi.org/10.1002/mds.26003.CrossRef Kalliolia, E., Silajdžić, E., Nambron, R., Hill, N. R., Doshi, A., Frost, C., et al. (2014). Plasma melatonin is reduced in Huntington’s disease. Movement Disorders: Official Journal of the Movement Disorder Society, 29(12), 1511–1515. https://​doi.​org/​10.​1002/​mds.​26003.CrossRef
Zurück zum Zitat Kalman, B. A., & Grahn, R. E. (2004). Measuring salivary cortisol in the behavioral neuroscience laboratory. Journal of Undergraduate Neuroscience Education: JUNE: A Publication of FUN, Faculty for Undergraduate Neuroscience, 2(2), A41–A49. Kalman, B. A., & Grahn, R. E. (2004). Measuring salivary cortisol in the behavioral neuroscience laboratory. Journal of Undergraduate Neuroscience Education: JUNE: A Publication of FUN, Faculty for Undergraduate Neuroscience, 2(2), A41–A49.
Zurück zum Zitat Kapadia, R., Yi, J.-H., & Vemuganti, R. (2008). Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists. Frontiers in Bioscience: A Journal and Virtual Library, 13, 1813–1826.CrossRef Kapadia, R., Yi, J.-H., & Vemuganti, R. (2008). Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists. Frontiers in Bioscience: A Journal and Virtual Library, 13, 1813–1826.CrossRef
Zurück zum Zitat Kim, E. J., Kwon, K. J., Park, J. Y., Lee, S. H., Moon, C. H., & Baik, E. J. (2002). Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: Associated with iNOS and COX-2. Brain Research, 941(1–2), 1–10.PubMedCrossRef Kim, E. J., Kwon, K. J., Park, J. Y., Lee, S. H., Moon, C. H., & Baik, E. J. (2002). Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: Associated with iNOS and COX-2. Brain Research, 941(1–2), 1–10.PubMedCrossRef
Zurück zum Zitat Kondepudi, D., & Prigogine, I. (1999). Modern thermodynamics from heat engines to dissipative structures. New York: Willey. Kondepudi, D., & Prigogine, I. (1999). Modern thermodynamics from heat engines to dissipative structures. New York: Willey.
Zurück zum Zitat Kuljis, D., Schroeder, A. M., Kudo, T., Loh, D. H., Willison, D. L., & Colwell, C. S. (2012). Sleep and circadian dysfunction in neurodegenerative disorders: insights from a mouse model of Huntington’s disease. Minerva Pneumologica, 51(3), 93–106.PubMedPubMedCentral Kuljis, D., Schroeder, A. M., Kudo, T., Loh, D. H., Willison, D. L., & Colwell, C. S. (2012). Sleep and circadian dysfunction in neurodegenerative disorders: insights from a mouse model of Huntington’s disease. Minerva Pneumologica, 51(3), 93–106.PubMedPubMedCentral
Zurück zum Zitat L’episcopo, F., Serapide, M. F., Tirolo, C., Testa, N., Caniglia, S., Morale, M. C., et al. (2011). A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection. Molecular Neurodegeneration, 6, 49. https://doi.org/10.1186/1750-1326-6-49.PubMedPubMedCentralCrossRef L’episcopo, F., Serapide, M. F., Tirolo, C., Testa, N., Caniglia, S., Morale, M. C., et al. (2011). A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection. Molecular Neurodegeneration, 6, 49. https://​doi.​org/​10.​1186/​1750-1326-6-49.PubMedPubMedCentralCrossRef
Zurück zum Zitat L’Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Morale, M. C., Deleidi, M., et al. (2012). Plasticity of subventricular zone neuroprogenitors in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson’s disease involves cross talk between inflammatory and Wnt/β-catenin signaling pathways: functional consequences for neuroprotection and repair. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 32(6), 2062–2085. https://doi.org/10.1523/jneurosci.5259-11.2012.CrossRef L’Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Morale, M. C., Deleidi, M., et al. (2012). Plasticity of subventricular zone neuroprogenitors in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson’s disease involves cross talk between inflammatory and Wnt/β-catenin signaling pathways: functional consequences for neuroprotection and repair. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 32(6), 2062–2085. https://​doi.​org/​10.​1523/​jneurosci.​5259-11.​2012.CrossRef
Zurück zum Zitat Loewenstein, R. J., Weingartner, H., Gillin, J. C., Kaye, W., Ebert, M., & Mendelson, W. B. (1982). Disturbances of sleep and cognitive functioning in patients with dementia. Neurobiology of Aging, 3(4), 371–377.PubMedCrossRef Loewenstein, R. J., Weingartner, H., Gillin, J. C., Kaye, W., Ebert, M., & Mendelson, W. B. (1982). Disturbances of sleep and cognitive functioning in patients with dementia. Neurobiology of Aging, 3(4), 371–377.PubMedCrossRef
Zurück zum Zitat Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., et al. (2002). Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Molecular Cell, 10(3), 457–468.PubMedCrossRef Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., et al. (2002). Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Molecular Cell, 10(3), 457–468.PubMedCrossRef
Zurück zum Zitat Luna-Medina, R., Cortes-Canteli, M., Alonso, M., Santos, A., Martínez, A., & Perez-Castillo, A. (2005). Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation. The Journal of biological chemistry, 280(22), 21453–21462. https://doi.org/10.1074/jbc.m414390200.PubMedCrossRef Luna-Medina, R., Cortes-Canteli, M., Alonso, M., Santos, A., Martínez, A., & Perez-Castillo, A. (2005). Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation. The Journal of biological chemistry, 280(22), 21453–21462. https://​doi.​org/​10.​1074/​jbc.​m414390200.PubMedCrossRef
Zurück zum Zitat Maywood, E. S., Fraenkel, E., McAllister, C. J., Wood, N., Reddy, A. B., Hastings, M. H., et al. (2010). Disruption of peripheral circadian timekeeping in a mouse model of Huntington’s disease and its restoration by temporally scheduled feeding. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30(30), 10199–10204. https://doi.org/10.1523/jneurosci.1694-10.2010.CrossRef Maywood, E. S., Fraenkel, E., McAllister, C. J., Wood, N., Reddy, A. B., Hastings, M. H., et al. (2010). Disruption of peripheral circadian timekeeping in a mouse model of Huntington’s disease and its restoration by temporally scheduled feeding. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30(30), 10199–10204. https://​doi.​org/​10.​1523/​jneurosci.​1694-10.​2010.CrossRef
Zurück zum Zitat McEwen, B. S. (2000). The neurobiology of stress: From serendipity to clinical relevance. Brain Research, 886(1–2), 172–189.PubMedCrossRef McEwen, B. S. (2000). The neurobiology of stress: From serendipity to clinical relevance. Brain Research, 886(1–2), 172–189.PubMedCrossRef
Zurück zum Zitat Mizobuchi, M., Hineno, T., Kakimoto, Y., & Hiratani, K. (1993). Increase of plasma adrenocorticotrophin and cortisol in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated dogs. Brain Research, 612(1–2), 319–321.PubMedCrossRef Mizobuchi, M., Hineno, T., Kakimoto, Y., & Hiratani, K. (1993). Increase of plasma adrenocorticotrophin and cortisol in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated dogs. Brain Research, 612(1–2), 319–321.PubMedCrossRef
Zurück zum Zitat Naia, L., Ferreira, I. L., Cunha-Oliveira, T., Duarte, A. I., Ribeiro, M., Rosenstock, T. R., et al. (2015). Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington’s Disease human lymphoblasts. Molecular Neurobiology, 51(1), 331–348. https://doi.org/10.1007/s12035-014-8735-4.PubMedCrossRef Naia, L., Ferreira, I. L., Cunha-Oliveira, T., Duarte, A. I., Ribeiro, M., Rosenstock, T. R., et al. (2015). Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington’s Disease human lymphoblasts. Molecular Neurobiology, 51(1), 331–348. https://​doi.​org/​10.​1007/​s12035-014-8735-4.PubMedCrossRef
Zurück zum Zitat Nenov, M. N., Laezza, F., Haidacher, S. J., Zhao, Y., Sadygov, R. G., Starkey, J. M., et al. (2014). Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 34(3), 1028–1036. https://doi.org/10.1523/jneurosci.3413-13.2014.CrossRef Nenov, M. N., Laezza, F., Haidacher, S. J., Zhao, Y., Sadygov, R. G., Starkey, J. M., et al. (2014). Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 34(3), 1028–1036. https://​doi.​org/​10.​1523/​jneurosci.​3413-13.​2014.CrossRef
Zurück zum Zitat Newington, J. T., Rappon, T., Albers, S., Wong, D. Y., Rylett, R. J., & Cumming, R. C. (2012). Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production. The Journal of biological chemistry, 287(44), 37245–37258. https://doi.org/10.1074/jbc.m112.366195.PubMedPubMedCentralCrossRef Newington, J. T., Rappon, T., Albers, S., Wong, D. Y., Rylett, R. J., & Cumming, R. C. (2012). Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production. The Journal of biological chemistry, 287(44), 37245–37258. https://​doi.​org/​10.​1074/​jbc.​m112.​366195.PubMedPubMedCentralCrossRef
Zurück zum Zitat Nicolis, G., & Prigogine, I. (1971). Fluctuations in nonequilibrium systems. Proceedings of the National Academy of Sciences of the United States of America, 68(9), 2102–2107.PubMedPubMedCentralCrossRef Nicolis, G., & Prigogine, I. (1971). Fluctuations in nonequilibrium systems. Proceedings of the National Academy of Sciences of the United States of America, 68(9), 2102–2107.PubMedPubMedCentralCrossRef
Zurück zum Zitat Parish, C. L., Castelo-Branco, G., Rawal, N., Tonnesen, J., Sorensen, A. T., Salto, C., et al. (2008). Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. The Journal of Clinical Investigation, 118(1), 149–160. https://doi.org/10.1172/jci32273.PubMedCrossRef Parish, C. L., Castelo-Branco, G., Rawal, N., Tonnesen, J., Sorensen, A. T., Salto, C., et al. (2008). Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. The Journal of Clinical Investigation, 118(1), 149–160. https://​doi.​org/​10.​1172/​jci32273.PubMedCrossRef
Zurück zum Zitat Patel, A. B., Lai, J. C. K., Chowdhury, G. M. I., Hyder, F., Rothman, D. L., Shulman, R. G., et al. (2014). Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle. Proceedings of the National Academy of Sciences of the United States of America, 111(14), 5385–5390. https://doi.org/10.1073/pnas.1403576111.PubMedPubMedCentralCrossRef Patel, A. B., Lai, J. C. K., Chowdhury, G. M. I., Hyder, F., Rothman, D. L., Shulman, R. G., et al. (2014). Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle. Proceedings of the National Academy of Sciences of the United States of America, 111(14), 5385–5390. https://​doi.​org/​10.​1073/​pnas.​1403576111.PubMedPubMedCentralCrossRef
Zurück zum Zitat Pesah, Y., Pham, T., Burgess, H., Middlebrooks, B., Verstreken, P., Zhou, Y., et al. (2004). Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development (Cambridge, England), 131(9), 2183–2194. https://doi.org/10.1242/dev.01095.CrossRef Pesah, Y., Pham, T., Burgess, H., Middlebrooks, B., Verstreken, P., Zhou, Y., et al. (2004). Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development (Cambridge, England), 131(9), 2183–2194. https://​doi.​org/​10.​1242/​dev.​01095.CrossRef
Zurück zum Zitat Piccini, P., Del Dotto, P., Pardini, C., D’Antonio, P., Rossi, G., & Bonuccelli, U. (1991). Diurnal worsening in Parkinson patients treated with levodopa. Rivista Di Neurologia, 61(6), 219–224.PubMed Piccini, P., Del Dotto, P., Pardini, C., D’Antonio, P., Rossi, G., & Bonuccelli, U. (1991). Diurnal worsening in Parkinson patients treated with levodopa. Rivista Di Neurologia, 61(6), 219–224.PubMed
Zurück zum Zitat Prigogine, I., & Nicolis, G. (1971). Biological order, structure and instabilities. Quarterly Reviews of Biophysics, 4(2), 107–148.PubMedCrossRef Prigogine, I., & Nicolis, G. (1971). Biological order, structure and instabilities. Quarterly Reviews of Biophysics, 4(2), 107–148.PubMedCrossRef
Zurück zum Zitat Prigogine, I., Nicolis, G., & Babloyantz, A. (1974). Nonequilibrium problems in biological phenomena. Annals of the New York Academy of Sciences, 231(1), 99–105.PubMedCrossRef Prigogine, I., Nicolis, G., & Babloyantz, A. (1974). Nonequilibrium problems in biological phenomena. Annals of the New York Academy of Sciences, 231(1), 99–105.PubMedCrossRef
Zurück zum Zitat Ramos, M., del Arco, A., Pardo, B., Martínez-Serrano, A., Martínez-Morales, J. R., Kobayashi, K., et al. (2003). Developmental changes in the Ca2+-regulated mitochondrial aspartate-glutamate carrier aralar1 in brain and prominent expression in the spinal cord. Brain Research. Developmental Brain Research, 143(1), 33–46.PubMedCrossRef Ramos, M., del Arco, A., Pardo, B., Martínez-Serrano, A., Martínez-Morales, J. R., Kobayashi, K., et al. (2003). Developmental changes in the Ca2+-regulated mitochondrial aspartate-glutamate carrier aralar1 in brain and prominent expression in the spinal cord. Brain Research. Developmental Brain Research, 143(1), 33–46.PubMedCrossRef
Zurück zum Zitat Riggs, J. E. (1998). Aging, increasing genomic entropy, and neurodegenerative disease. Neurologic Clinics, 16(3), 757–770.PubMedCrossRef Riggs, J. E. (1998). Aging, increasing genomic entropy, and neurodegenerative disease. Neurologic Clinics, 16(3), 757–770.PubMedCrossRef
Zurück zum Zitat Roche, T. E., Baker, J. C., Yan, X., Hiromasa, Y., Gong, X., Peng, T., et al. (2001). Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. Progress in Nucleic Acid Research and Molecular Biology, 70, 33–75.PubMedCrossRef Roche, T. E., Baker, J. C., Yan, X., Hiromasa, Y., Gong, X., Peng, T., et al. (2001). Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. Progress in Nucleic Acid Research and Molecular Biology, 70, 33–75.PubMedCrossRef
Zurück zum Zitat Sandler, S. (2006). Chemical and engineering thermodynamics (4th ed.). New-York: Wiely. Sandler, S. (2006). Chemical and engineering thermodynamics (4th ed.). New-York: Wiely.
Zurück zum Zitat Schibler, U., & Sassone-Corsi, P. (2002). A web of circadian pacemakers. Cell, 111(7), 919–922.PubMedCrossRef Schibler, U., & Sassone-Corsi, P. (2002). A web of circadian pacemakers. Cell, 111(7), 919–922.PubMedCrossRef
Zurück zum Zitat Schmidt, M., Fernandez de Mattos, S., van der Horst, A., Klompmaker, R., Kops, G. J. P. L., Lam, E. W.-F., et al. (2002). Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Molecular and Cellular Biology, 22(22), 7842–7852.PubMedPubMedCentralCrossRef Schmidt, M., Fernandez de Mattos, S., van der Horst, A., Klompmaker, R., Kops, G. J. P. L., Lam, E. W.-F., et al. (2002). Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Molecular and Cellular Biology, 22(22), 7842–7852.PubMedPubMedCentralCrossRef
Zurück zum Zitat Schreiber, S. L. (1991). Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science (New York, N.Y.), 251(4991), 283–287.CrossRef Schreiber, S. L. (1991). Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science (New York, N.Y.), 251(4991), 283–287.CrossRef
Zurück zum Zitat Shang, Y. C., Chong, Z. Z., Hou, J., & Maiese, K. (2009). The forkhead transcription factor FOXO3a controls microglial inflammatory activation and eventual apoptotic injury through caspase 3. Current Neurovascular Research, 6(1), 20–31.PubMedPubMedCentralCrossRef Shang, Y. C., Chong, Z. Z., Hou, J., & Maiese, K. (2009). The forkhead transcription factor FOXO3a controls microglial inflammatory activation and eventual apoptotic injury through caspase 3. Current Neurovascular Research, 6(1), 20–31.PubMedPubMedCentralCrossRef
Zurück zum Zitat Sharma, C., Pradeep, A., Wong, L., Rana, A., & Rana, B. (2004). Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway. The Journal of biological chemistry, 279(34), 35583–35594. https://doi.org/10.1074/jbc.m403143200.PubMedCrossRef Sharma, C., Pradeep, A., Wong, L., Rana, A., & Rana, B. (2004). Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway. The Journal of biological chemistry, 279(34), 35583–35594. https://​doi.​org/​10.​1074/​jbc.​m403143200.PubMedCrossRef
Zurück zum Zitat Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R., et al. (1999). The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proceedings of the National Academy of Sciences of the United States of America, 96(10), 5522–5527.PubMedPubMedCentralCrossRef Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R., et al. (1999). The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proceedings of the National Academy of Sciences of the United States of America, 96(10), 5522–5527.PubMedPubMedCentralCrossRef
Zurück zum Zitat Siersbæk, M. S., Loft, A., Aagaard, M. M., Nielsen, R., Schmidt, S. F., Petrovic, N., et al. (2012). Genome-wide profiling of peroxisome proliferator-activated receptor γ in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression. Molecular and Cellular Biology, 32(17), 3452–3463. https://doi.org/10.1128/mcb.00526-12.PubMedPubMedCentralCrossRef Siersbæk, M. S., Loft, A., Aagaard, M. M., Nielsen, R., Schmidt, S. F., Petrovic, N., et al. (2012). Genome-wide profiling of peroxisome proliferator-activated receptor γ in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression. Molecular and Cellular Biology, 32(17), 3452–3463. https://​doi.​org/​10.​1128/​mcb.​00526-12.PubMedPubMedCentralCrossRef
Zurück zum Zitat Simpson, I. A., Carruthers, A., & Vannucci, S. J. (2007). Supply and demand in cerebral energy metabolism: The role of nutrient transporters. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 27(11), 1766–1791. https://doi.org/10.1038/sj.jcbfm.9600521.CrossRef Simpson, I. A., Carruthers, A., & Vannucci, S. J. (2007). Supply and demand in cerebral energy metabolism: The role of nutrient transporters. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 27(11), 1766–1791. https://​doi.​org/​10.​1038/​sj.​jcbfm.​9600521.CrossRef
Zurück zum Zitat Skene, D. J., & Swaab, D. F. (2003). Melatonin rhythmicity: effect of age and Alzheimer’s disease. Experimental Gerontology, 38(1–2), 199–206.PubMedCrossRef Skene, D. J., & Swaab, D. F. (2003). Melatonin rhythmicity: effect of age and Alzheimer’s disease. Experimental Gerontology, 38(1–2), 199–206.PubMedCrossRef
Zurück zum Zitat Sochocka, M., Koutsouraki, E. S., Gasiorowski, K., & Leszek, J. (2013). Vascular oxidative stress and mitochondrial failure in the pathobiology of Alzheimer’s disease: A new approach to therapy. CNS & Neurological Disorders: Drug Targets, 12(6), 870–881.CrossRef Sochocka, M., Koutsouraki, E. S., Gasiorowski, K., & Leszek, J. (2013). Vascular oxidative stress and mitochondrial failure in the pathobiology of Alzheimer’s disease: A new approach to therapy. CNS & Neurological Disorders: Drug Targets, 12(6), 870–881.CrossRef
Zurück zum Zitat Soucek, T., Cumming, R., Dargusch, R., Maher, P., & Schubert, D. (2003). The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. Neuron, 39(1), 43–56.PubMedCrossRef Soucek, T., Cumming, R., Dargusch, R., Maher, P., & Schubert, D. (2003). The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. Neuron, 39(1), 43–56.PubMedCrossRef
Zurück zum Zitat Stahl, M., Dijkers, P. F., Kops, G. J. P. L., Lens, S. M. A., Coffer, P. J., Burgering, B. M. T., et al. (2002). The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. Journal of Immunology (Baltimore, Md.: 1950), 168(10), 5024–5031.CrossRef Stahl, M., Dijkers, P. F., Kops, G. J. P. L., Lens, S. M. A., Coffer, P. J., Burgering, B. M. T., et al. (2002). The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. Journal of Immunology (Baltimore, Md.: 1950), 168(10), 5024–5031.CrossRef
Zurück zum Zitat Sterniczuk, R., Theou, O., Rusak, B., & Rockwood, K. (2013). Sleep disturbance is associated with incident dementia and mortality. Current Alzheimer Research, 10(7), 767–775.PubMedCrossRef Sterniczuk, R., Theou, O., Rusak, B., & Rockwood, K. (2013). Sleep disturbance is associated with incident dementia and mortality. Current Alzheimer Research, 10(7), 767–775.PubMedCrossRef
Zurück zum Zitat St-Pierre, J., Lin, J., Krauss, S., Tarr, P. T., Yang, R., Newgard, C. B., et al. (2003). Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. The Journal of biological chemistry, 278(29), 26597–26603. https://doi.org/10.1074/jbc.m301850200.PubMedCrossRef St-Pierre, J., Lin, J., Krauss, S., Tarr, P. T., Yang, R., Newgard, C. B., et al. (2003). Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. The Journal of biological chemistry, 278(29), 26597–26603. https://​doi.​org/​10.​1074/​jbc.​m301850200.PubMedCrossRef
Zurück zum Zitat Struck, L. K., Rodnitzky, R. L., & Dobson, J. K. (1990). Circadian fluctuations of contrast sensitivity in Parkinson’s disease. Neurology, 40(3 Pt 1), 467–470.PubMedCrossRef Struck, L. K., Rodnitzky, R. L., & Dobson, J. K. (1990). Circadian fluctuations of contrast sensitivity in Parkinson’s disease. Neurology, 40(3 Pt 1), 467–470.PubMedCrossRef
Zurück zum Zitat Strum, J. C., Shehee, R., Virley, D., Richardson, J., Mattie, M., Selley, P., et al. (2007). Rosiglitazone induces mitochondrial biogenesis in mouse brain. Journal of Alzheimer’s disease: JAD, 11(1), 45–51.PubMedCrossRef Strum, J. C., Shehee, R., Virley, D., Richardson, J., Mattie, M., Selley, P., et al. (2007). Rosiglitazone induces mitochondrial biogenesis in mouse brain. Journal of Alzheimer’s disease: JAD, 11(1), 45–51.PubMedCrossRef
Zurück zum Zitat Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2017e). Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer’s disease. Acta Biochimica et Biophysica Sinica, 49(10), 853–866. https://doi.org/10.1093/abbs/gmx073.PubMedCrossRef Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2017e). Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer’s disease. Acta Biochimica et Biophysica Sinica, 49(10), 853–866. https://​doi.​org/​10.​1093/​abbs/​gmx073.PubMedCrossRef
Zurück zum Zitat Warburg, O. (1956). On the origin of cancer cells. Science (New York, N.Y.), 123(3191), 309–314.CrossRef Warburg, O. (1956). On the origin of cancer cells. Science (New York, N.Y.), 123(3191), 309–314.CrossRef
Zurück zum Zitat Wu, Y.-H., Fischer, D. F., Kalsbeek, A., Garidou-Boof, M.-L., van der Vliet, J., van Heijningen, C., et al. (2006). Pineal clock gene oscillation is disturbed in Alzheimer’s disease, due to functional disconnection from the “master clock”. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 20(11), 1874–1876. https://doi.org/10.1096/fj.05-4446fje.CrossRef Wu, Y.-H., Fischer, D. F., Kalsbeek, A., Garidou-Boof, M.-L., van der Vliet, J., van Heijningen, C., et al. (2006). Pineal clock gene oscillation is disturbed in Alzheimer’s disease, due to functional disconnection from the “master clock”. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 20(11), 1874–1876. https://​doi.​org/​10.​1096/​fj.​05-4446fje.CrossRef
Zurück zum Zitat Wu, D., & Pan, W. (2010). GSK3: A multifaceted kinase in Wnt signaling. Trends in Biochemical Sciences, 35(3), 161–168.PubMedCrossRef Wu, D., & Pan, W. (2010). GSK3: A multifaceted kinase in Wnt signaling. Trends in Biochemical Sciences, 35(3), 161–168.PubMedCrossRef
Zurück zum Zitat Xu, C., Wang, J., Zhu, T., Shen, Y., Tang, X., Fang, L., et al. (2016). Cross-talking between PPAR and WNT signaling and its regulation in mesenchymal stem cell differentiation. Current Stem Cell Research & Therapy, 11(3), 247–254.CrossRef Xu, C., Wang, J., Zhu, T., Shen, Y., Tang, X., Fang, L., et al. (2016). Cross-talking between PPAR and WNT signaling and its regulation in mesenchymal stem cell differentiation. Current Stem Cell Research & Therapy, 11(3), 247–254.CrossRef
Zurück zum Zitat Yaffe, M. B., Schutkowski, M., Shen, M., Zhou, X. Z., Stukenberg, P. T., Rahfeld, J. U., et al. (1997). Sequence-specific and phosphorylation-dependent proline isomerization: A potential mitotic regulatory mechanism. Science (New York, N.Y.), 278(5345), 1957–1960.CrossRef Yaffe, M. B., Schutkowski, M., Shen, M., Zhou, X. Z., Stukenberg, P. T., Rahfeld, J. U., et al. (1997). Sequence-specific and phosphorylation-dependent proline isomerization: A potential mitotic regulatory mechanism. Science (New York, N.Y.), 278(5345), 1957–1960.CrossRef
Zurück zum Zitat Yang, X., Wood, P. A., Ansell, C. M., Ohmori, M., Oh, E.-Y., Xiong, Y., et al. (2009). Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice. Journal of Biochemistry, 145(3), 289–297. https://doi.org/10.1093/jb/mvn167.PubMedCrossRef Yang, X., Wood, P. A., Ansell, C. M., Ohmori, M., Oh, E.-Y., Xiong, Y., et al. (2009). Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice. Journal of Biochemistry, 145(3), 289–297. https://​doi.​org/​10.​1093/​jb/​mvn167.PubMedCrossRef
Metadaten
Titel
Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway–PPAR Gamma, Energy Metabolism and Circadian Rhythms
verfasst von
Alexandre Vallée
Yves Lecarpentier
Rémy Guillevin
Jean-Noël Vallée
Publikationsdatum
23.03.2018
Verlag
Springer US
Erschienen in
NeuroMolecular Medicine / Ausgabe 2/2018
Print ISSN: 1535-1084
Elektronische ISSN: 1559-1174
DOI
https://doi.org/10.1007/s12017-018-8486-x

Weitere Artikel der Ausgabe 2/2018

NeuroMolecular Medicine 2/2018 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.