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12.09.2016 | Neurology and Preclinical Neurological Studies - Original Article

Theta burst stimulation over premotor cortex in Parkinson’s disease: an explorative study on manual dexterity

verfasst von: Tim Vanbellingen, Manuela Wapp, Katharina Stegmayer, Manuel Bertschi, Eugenio Abela, Stefanie Kübel, Thomas Nyffeler, René Müri, Sebastian Walther, Tobias Nef, Mark Hallett, Stephan Bohlhalter

Erschienen in: Journal of Neural Transmission | Ausgabe 12/2016

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Abstract

Dorsal pre-motor cortex (PMd) is thought to play a role in fine motor control. The aim of the present study was to investigate whether inhibitory or excitatory stimulation of PMd would have an impact on manual dexterity in Parkinson’s disease (PD). Fifteen patients with PD participated in this study. High resolution structural MRI was used for neuro-navigated TBS. Participants were targeted with one train of TBS in three experimental sessions: sham stimulation over vertex, continuous TBS (cTBS) over PMd and intermittent TBS (iTBS) over PMd, respectively. Dexterity was measured by a coin rotation task (CRT), which is a valid measure to detect limb kinetic apraxia (LKA). Neither cTBS or iTBS significantly interfered with CRT. Post hoc sub-analysis in a group of PD patients (n = 5) with stronger baseline impairment, indicating LKA, revealed further deterioration of dexterous performance for the cTBS condition (p = 0.04). This sham controlled pilot study demonstrates that TBS over PMd does not significantly interfere with dexterity in PD. However, patients with dexterous impairment qualifying for LKA may be more susceptible to TBS.

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Titel: Theta burst stimulation over premotor cortex in Parkinson’s disease: an explorative study on manual dexterity
verfasst von: Tim Vanbellingen
Manuela Wapp
Katharina Stegmayer
Manuel Bertschi
Eugenio Abela
Stefanie Kübel
Thomas Nyffeler
René Müri
Sebastian Walther
Tobias Nef
Mark Hallett
Stephan Bohlhalter
Publikationsdatum: 12.09.2016
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 12/2016
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-016-1614-6

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