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Erschienen in: Medical Oncology 4/2014

01.04.2014 | Short Communication

Thin melanoma and late recurrences: it is never too thin and never too late

verfasst von: Antonio Giovanni Richetta, Ugo Bottoni, Giovanni Paolino, Rita Clerico, Carmen Cantisani, Marina Ambrifi, Paola Corsetti, Stefano Calvieri

Erschienen in: Medical Oncology | Ausgabe 4/2014

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Abstract

In the absence of risk factors, thin melanomas (TM) present a long-term survival; however, recurrences may occur. We describe the predictive clinicopathological features of patients with metastatic TM. Kaplan–Meier product was performed for the survival analysis, while Cox proportional hazards regression was used to evaluate the effect of the clinicopathological features on disease-free survival (DFS) and overall survival (OS). Median DFS of the entire cohort was 26 months and three patients developed late metastases. Nine patients developed extra-nodal metastases as first recurrence, while cases of positive sentinel lymph node biopsy (SLNB) were not found. DFS and OS varied according to the clinicopathological features, but only ulceration remained the main statistical significance value. According to our results, a hypothetical use of SLNB in TM without other risk factors is not currently feasible. No consensus exists as to which patients with TM are at risk for metastases or late recurrences.
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Metadaten
Titel
Thin melanoma and late recurrences: it is never too thin and never too late
verfasst von
Antonio Giovanni Richetta
Ugo Bottoni
Giovanni Paolino
Rita Clerico
Carmen Cantisani
Marina Ambrifi
Paola Corsetti
Stefano Calvieri
Publikationsdatum
01.04.2014
Verlag
Springer US
Erschienen in
Medical Oncology / Ausgabe 4/2014
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-014-0909-4

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