nach oben

European Spine Journal

Erschienen in:

04.10.2016 | Original Article

Thoracic spine morphology of a pseudo-biped animal model (kangaroo) and comparisons with human and quadruped animals

verfasst von: Sriram Balasubramanian, James R. Peters, Lucy F. Robinson, Anita Singh, Richard W. Kent

Erschienen in: European Spine Journal | Ausgabe 12/2016

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Based on the structural anatomy, loading condition and range of motion (ROM), no quadruped animal has been shown to accurately mimic the structure and biomechanical function of the human spine. The objective of this study is to quantify the thoracic vertebrae geometry of the kangaroo, and compare with adult human, pig, sheep, and deer.

Methods

The thoracic vertebrae (T1–T12) from whole body CT scans of ten juvenile kangaroos (ages 11–14 months) were digitally reconstructed and geometric dimensions of the vertebral bodies, endplates, pedicles, spinal canal, processes, facets and intervertebral discs were recorded. Similar data available in the literature on the adult human, pig, sheep, and deer were compared to the kangaroo. A non-parametric trend analysis was performed.

Results

Thoracic vertebral dimensions of the juvenile kangaroo were found to be generally smaller than those of the adult human and quadruped animals. The most significant (p < 0.001) correlations (Rho) found between the human and kangaroo were in vertebrae and endplate dimensions (0.951 ≤ Rho ≤ 0.963), pedicles (0.851 ≤ Rho ≤ 0.951), and inter-facet heights (0.891 ≤ Rho ≤ 0.967). The deer displayed the least similar trends across vertebral levels.

Conclusions

Similarities in thoracic spine vertebral geometry, particularly of the vertebrae, pedicles and facets may render the kangaroo a more clinically relevant human surrogate for testing spinal implants. The pseudo-biped kangaroo may also be a more suitable model for the human thoracic spine for simulating spine deformities, based on previously published similarities in biomechanical loading, posture and ROM.

Akbarnia BA, Cheung K, Noordeen H et al. (2013). Next Generation of Growth-Sparing Technique: Preliminary Clinical Results of a Magnetically Controlled Growing Rod (MCGR) in 14 Patients With Early Onset Scoliosis. Spine 38(8):665–70CrossRefPubMed

Deviren V, Acaroglu E, Lee J et al (2005) Pedicle screw fixation of the thoracic spine: an in vitro biomechanical study on different configurations. Spine 30(22):2530–2537CrossRefPubMed

Helgeson MD, Kang DG, Lehman RA Jr, Dmitriev AE, Luhmann SJ (2013) Tapping insertional torque allows prediction for better pedicle screw fixation and optimal screw size selection. Spine J. 13(8):957–965CrossRefPubMed

Mannen EM, Anderson JT, Arnold PM, Friis EA (2015) Mechanical analysis of the human cadaveric thoracic spine with intact rib cage. J Biomech 48(10):2060–2066CrossRefPubMed

McCarthy RE, Luhmann S, Lenke L, McCullough FL (2014) The shilla growth guidance technique for early-onset spinal deformities at 2-year follow-up: a preliminary report. J Pediatr Orthop 34(1):1–7CrossRefPubMed

Olgun ZD, Ahmadiadli H, Alanay A, Yazici M (2012) Vertebral body growth during growing rod instrumentation: growth preservation or stimulation? J Pediatr Orthop 32(2):184–189CrossRefPubMed

Janssen MM, de Wilde RF, Kouwenhoven JW, Castelein RM (2011) Experimental animal models in scoliosis research: a review of the literature. Spine J 11(4):347–358CrossRefPubMed

Agadir M, Sevastik B, Sevastik JA, Persson A, Isberg B (1988) Induction of scoliosis in the growing rabbit by unilateral rib-growth stimulation. Spine 13(9):1065–1069CrossRefPubMed

Braun JT, Hoffman M, Akyuz E, Ogilvie JW, Brodke DS, Bachus KN (2006) Mechanical modulation of vertebral growth in the fusionless treatment of progressive scoliosis in an experimental model. Spine. 31(12):1314–1320CrossRefPubMed

10.

Braun JT, Ogilvie JW, Akyuz E, Brodke DS, Bachus KN (2006) Creation of an experimental idiopathic-type scoliosis in an immature goat model using a flexible posterior asymmetric tether. Spine 31(13):1410–1414CrossRefPubMed

11.

Fekete TF, Kleinstück FS, Mannion AF, Kendik ZS, Jeszenszky DJ (2011) Prospective study of the effect of pedicle screw placement on development of the immature vertebra in an in vivo porcine model. Eur Spine J 20(11):1892–1898CrossRefPubMedPubMedCentral

12.

Kanemura T, Kawakami N, Deguchi M, Mimatsu K, Iwata H (1997) Natural Course of experimental scoliosis in pinealectomized chickens. Spine 22(14):1563–1567CrossRefPubMed

13.

McLain RF, Yerby SA, Moseley TA (2002) Comparative morphometry of L4 vertebrae comparison of large animal models for the human lumbar spine. Spine 27(8):E200–E206CrossRefPubMed

14.

Newton PO, Farnsworth CL, Upasani VV, Chambers RC, Varley E, Tsutsui S (2011) Effects of intraoperative tensioning of an anterolateral spinal tether on spinal growth modulation in a porcine model. Spine 36(2):109–117CrossRefPubMed

15.

Newton PO, Fricka KB, Lee SS, Farnsworth CL, Cox TG, Mahar AT (2002) Asymmetrical flexible tethering of spine growth in an immature bovine model. Spine 27(7):689–693CrossRefPubMed

16.

Olson EJ, Hanley EN, Rudert MJ, Baratz ME (1991) Vertebral column allografts for the treatment of segmental spine defects—an experimental investigation in dogs. Spine 16(9):1081–1088CrossRefPubMed

17.

Alini M, Eisenstein SM, Ito K et al (2008) Are animal models useful for studying human disc disorders/degeneration? Eur Spine J 17(1):2–19CrossRefPubMed

18.

Kettler A, Liakos L, Haegele B, Wilke HJ (2007) Are the spines of calf, pig and sheep suitable models for pre-clinical implant tests? Eur Spine J 16(12):2186–2192CrossRefPubMedPubMedCentral

19.

Sheng SR, Wang XY, Xu HZ, Zhu GQ, Zhou YF (2010) Anatomy of large animal spines and its comparison to the human spine: a systematic review. Eur Spine J 19(1):46–56CrossRefPubMed

20.

Boszczyk BM, Boszczyk AA, Putz R (2001) Comparative and functional anatomy of the mammalian lumbar spine. Anat Rec 264:157–168CrossRefPubMed

21.

Busscher I, van der Veen AJ, van Dieen JH, Kingma I, Verkerke GJ, Veldhuizen AG (2010) In vitro biomechanical characteristics of the spine: a comparison between human and porcine spinal segments. Spine 35(2):E35–E42CrossRefPubMed

22.

Jiang H, Moreau M, Raso JV, Russell G, Bagnall K (1995) A comparison of spinal ligaments-differences between bipeds and quadrupeds. J Anat 187:85–91PubMedPubMedCentral

23.

Smit TH (2002) The use of a quadruped as an in vivo model for the study of the spine—biomechanical considerations. Eur Spine J 11(2):137–144CrossRefPubMedPubMedCentral

24.

Animal models in orthopaedic research. Boca Raton, Florida: CRC Press LLC, 1999

25.

Boden SD, Moskovitz PA, Morone MA, Toribitake Y (1996) Video-assisted lateral intertransverse process arthrodesis validation of a new minimally invasive lumbar spinal fusion technique in the rabbit and nonhuman primate (Rhesus) Models. Spine 21(22):2689–2697CrossRefPubMed

26.

Tominaga T, Dickman CA, Sonntag VKH, Coons S (1995) Comparative anatomy of the baboon and human cervical spine. Spine. 20(2):131–137CrossRefPubMed

27.

Colliard C, Rivard CH (1996) Vertebral deformities and scoliosis. Eur Spine J 5:91–100CrossRef

28.

Deguchi M, Kawakami N, Kanemura T (1996) Correction of scoliosis by rib resection in pinealectomized chickens. J Spinal Disord 9(3):207–213CrossRefPubMed

29.

Machida M, Dubousset J, Imamura Y, Iwaya T, Yamada T, Kimura J (1993) An experimental study in chickens for the pathogenesis of idiopathic scoliosis. Spine 18(12):1609–1615CrossRefPubMed

30.

Machida M, Dubousset J, Imamura Y, Iwaya T, Yamada T, Kimura J (1995) Role of melatonin deficiency in the development of scoliosis in pinealectomised chickens. J Bone Jt Surg 77:134–138

31.

Machida M, Miyashita Y, Murai I, Dubousset J, Yamada T, Kimura J (1997) Role of Serotonin for scoliosis deformity in pinealectomized chickens. Spine. 22(12):1297–1301CrossRefPubMed

32.

Wang XY, Jiang H, Raso JV et al (1997) Characterization of the scoliosis that develops after pinealectomy in the chicken and comparison with adolescent idiopathic scoliosis in humans. Spine. 23(22):2626–2635CrossRef

33.

Hodge AJ, Neethling WM, Glancy R (2004) Evaluation of stentless kangaroo aortic valves in the mitral position of juvenile sheep. J Heart Valve Dis 13(4):681–688PubMed

34.

Narine KK, Kramm K, Dumont K et al (2006) Hydrodynamic evaluation of kangaroo aortic valve matrices for tissue valve engineering. Artif Organs 30(6):432–439CrossRefPubMed

35.

Neethling WM, Papadimitriou JM, Swarts E, Hodge AJ (2000) Kangaroo versus porcine aortic valve tissue–valve geometry morphology, tensile strength and calcification potential. J Cardiovasc Surg (Torino). 41(3):341–348PubMed

36.

Lau SH (2013) Assessment of Macropus giganteus as a biomechanical model of the pediatric thorax: the school of engineering and applied sciences, University of Verginia

37.

Hutchinson JR (2004) Biomechanical modeling and sensitivity analysis of bipedal running ability. I. Extant taxa. J Morphol 262(1):421–440CrossRefPubMed

38.

Department of Sustainability E, Water, Population and Communities (2012) Commercial kangaroo harvesting fact sheet. In: Department of sustainability E, water, population and communities (ed) Commonwealth of Australia: Commonwealth of Australia. https://www.environment.gov.au/biodiversity/wildlife-trade/publications/commercial-kangaroo-harvesting-fact-sheet-2012. Accessed 22 July 2016

39.

Peters JR, Chandrasekaran C, Robinson LF, Servaes SE, Campbell RM Jr, Balasubramanian S (2015) Age- and gender-related changes in pediatric thoracic vertebral morphology. Spine J 15(5):1000–1020CrossRefPubMed

40.

Panjabi MM, Oxland T, Takata K, Goel V, Duranceau J, Krag M (1993) Articular facets of the human spine quantitative three-dimensional anatomy. Spine 18(10):1298–1310CrossRefPubMed

41.

Panjabi MM, Takata K, Goel V et al (1991) Thoracic human vertebrae quantitative three-dimensional anatomy. Spine 16(8):888–901CrossRefPubMed

42.

Zindrick MR, Knight GW, Sartori MJ, Carnevale TJ, Patwardhan AG, Lorenz MA (2000) Pedicle morphology of the immature thoracolumbar spine. Spine 25(21):2726–2735CrossRefPubMed

43.

Busscher I, Ploegmakers JJ, Verkerke GJ, Veldhuizen AG (2010) Comparative anatomical dimensions of the complete human and porcine spine. Eur Spine J 19(7):1104–1114CrossRefPubMedPubMedCentral

44.

Kumar N, Kukreti S, Ishaque M, Mulholland R (2000) Anatomy of deer spine and its comparison to the human spine. Anat Rec 260:189–203CrossRefPubMed

45.

Wilke HJ, Kettler A, Claes LE (1997) Are sheep spines a valid biomechanical model for human spines? Spine 22(20):2365–2374CrossRefPubMed

46.

Standring S (2008) Gray’s anatomy, 40th edn. Elsevier, Churchill Livingstone

47.

White AA, Panjabi MM (1990) Clinical biomechanics of the spine, 2nd edn. J.B. Lippincott Company, Philadelphia

48.

Nahum AM, Melvin J (2002) Accidental injury: biomechanics and prevention. Springer, New YorkCrossRef

49.

Kretzer RM, Chaput C, Sciubba DM et al (2011) A computed tomography-based morphometric study of thoracic pedicle anatomy in a random United States trauma population. J Neurosurg Spine 14(2):235–243CrossRefPubMed

50.

Parent S, Labelle H, Skalli W, de Guise J (2001) Thoracic pedicle morphometry in vertebrae from scoliotic spines. Spine J 29(3):239–248CrossRef

51.

Lee MC, Solomito M, Patel A (2013) Supine magnetic resonance imaging cobb measurements for idiopathic scoliosis are linearly related to measurements from standing plain radiographs. Spine 38(11):E656–E661CrossRefPubMed

52.

Yazici M, Acaroglu ER, Alanay A, Deviren V, Cila A, Surat A (2001) Measurement of vertebral rotation in standing versus supine position in adolescent idiopathic scoliosis. J Pediatr Orthop 21:252–256PubMed

53.

Hasler C, Sprecher CM, Milz S (2010) Comparison of the immature sheep spine and the growing human spine a spondylometric database for growth modulating research. Spine 35(23):E1262–E1272CrossRefPubMed

54.

Chen X, Milne N, O’Higgins P (2005) Morphological variation of the thoracolumbar vertebrae in Macropodidae and its functional relevance. J Morphol 266(2):167–181CrossRefPubMed

55.

Ouellet J, Odent T (2013) Animal models for scoliosis research: state of the art, current concepts and future perspective applications. Eur Spine J 22(Suppl 2):S81–S95 CrossRefPubMed

56.

Bozkus H, Crawford NR, Chamberlain RH, Valenzuela TD, Espinoza A, Yüksel Z, Dickman CA (2005) Comparative anatomy of the porcine and human thoracic spines with reference to thoracoscopic surgical techniques. Surg Endosc 19(12):1652–1665CrossRefPubMed

Titel: Thoracic spine morphology of a pseudo-biped animal model (kangaroo) and comparisons with human and quadruped animals
verfasst von: Sriram Balasubramanian
James R. Peters
Lucy F. Robinson
Anita Singh
Richard W. Kent
Publikationsdatum: 04.10.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Spine Journal / Ausgabe 12/2016
Print ISSN: 0940-6719
Elektronische ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-016-4776-x

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen.
» Jetzt entdecken

Neu im Fachgebiet Orthopädie und Unfallchirurgie

18.04.2024 | Wirbelsäulenmetastase | Nachrichten

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Thoracic spine morphology of a pseudo-biped animal model (kangaroo) and comparisons with human and quadruped animals

Abstract

Purpose

Methods

Results

Conclusions

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Brustkrebs in der Vorgeschichte macht Gelenkersatz komplikationsträchtiger

Zwei neue Alternativen zu TNF-Inhibitoren bei axSpA

Update Orthopädie und Unfallchirurgie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 12/2016

Treatment options and prognosis for repeatedly recurrent giant cell tumor of the spine

Minimally invasive iliac screw fixation in treating painful metastatic lumbosacral deformity: a technique description and clinical results

Residual neurological function after sacral root resection during en-bloc sacrectomy: a systematic review

The timing of surgical intervention in the treatment of complete motor paralysis in patients with spinal metastasis

Letter to the Editor concerning “A prospective randomized controlled study comparing the pain relief in patients with osteoporotic vertebral compression fractures with the use of vertebroplasty or facet blocking” by Wang B, Guo H, Yuan L et al. Eur Spine J (2016): doi:10.1007/s00586-016-4425-4

Long-term recurrence rates after the removal of spinal meningiomas in relation to Simpson grades

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Brustkrebs in der Vorgeschichte macht Gelenkersatz komplikationsträchtiger

Zwei neue Alternativen zu TNF-Inhibitoren bei axSpA

Update Orthopädie und Unfallchirurgie