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Erschienen in: Journal of Neural Transmission 3/2017

11.11.2016 | Neurology and Preclinical Neurological Studies - Original Article

Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome

verfasst von: Félix Javier Jiménez-Jiménez, Elena García-Martín, Hortensia Alonso-Navarro, Carmen Martínez, Martín Zurdo, Laura Turpín-Fenoll, Jorge Millán-Pascual, Teresa Adeva-Bartolomé, Esther Cubo, Francisco Navacerrada, Ana Rojo-Sebastián, Lluisa Rubio, Sara Ortega-Cubero, Pau Pastor, Marisol Calleja, José Francisco Plaza-Nieto, Belén Pilo-de-la-Fuente, Margarita Arroyo-Solera, Esteban García-Albea, José A. G. Agúndez

Erschienen in: Journal of Neural Transmission | Ausgabe 3/2017

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Abstract

A recent meta-analysis suggests an association between the rs11558538 single nucleotide polymorphism in the histamine-N-methyl-transferase (HNMT) gene and the risk for Parkinson’s disease. Based on the possible relationship between PD and restless legs syndrome (RLS), we tried to establish whether rs11558538 SNP is associated with the risk for RLS. We studied the genotype and allelic variant frequencies of HNMT rs11558538 SNP 205 RLS patients and 410 healthy controls using a TaqMan assay. The frequencies of the HNMT rs11558538 genotypes allelic variants were similar between RLS patients and controls, and were not influenced by gender, family history of RLS, or RLS severity. RLS patients carrying the genotype rs11558538TT had an earlier age at onset, but this finding was based on three subjects only. These results suggest a lack of major association between HNMT rs11558538 SNP and the risk for RLS.
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Metadaten
Titel
Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome
verfasst von
Félix Javier Jiménez-Jiménez
Elena García-Martín
Hortensia Alonso-Navarro
Carmen Martínez
Martín Zurdo
Laura Turpín-Fenoll
Jorge Millán-Pascual
Teresa Adeva-Bartolomé
Esther Cubo
Francisco Navacerrada
Ana Rojo-Sebastián
Lluisa Rubio
Sara Ortega-Cubero
Pau Pastor
Marisol Calleja
José Francisco Plaza-Nieto
Belén Pilo-de-la-Fuente
Margarita Arroyo-Solera
Esteban García-Albea
José A. G. Agúndez
Publikationsdatum
11.11.2016
Verlag
Springer Vienna
Erschienen in
Journal of Neural Transmission / Ausgabe 3/2017
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-016-1645-z

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