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01.12.2018 | Research | Ausgabe 1/2018 Open Access

Journal of Cardiovascular Magnetic Resonance 1/2018

Three-dimensional free breathing whole heart cardiovascular magnetic resonance T1 mapping at 3 T

Zeitschrift:
Journal of Cardiovascular Magnetic Resonance > Ausgabe 1/2018
Autoren:
Rui Guo, Zhensen Chen, Yishi Wang, Daniel A. Herzka, Jianwen Luo, Haiyan Ding
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12968-018-0487-2) contains supplementary material, which is available to authorized users.

Abstract

Background

This study demonstrates a three-dimensional (3D) free-breathing native myocardial T1 mapping sequence at 3 T.

Methods

The proposed sequence acquires three differently T1-weighted volumes. The first two volumes receive a saturation pre-pulse with different recovery time. The third volume is acquired without magnetization preparation and after a significant recovery time. Respiratory navigator gating and volume-interleaved acquisition are adopted to mitigate misregistration. The proposed sequence was validated through simulation, phantom experiments and in vivo experiments in 12 healthy adult subjects.

Results

In phantoms, good agreement on T1 measurement was achieved between the proposed sequence and the reference inversion recovery spin echo sequence (R2 = 0.99). Homogeneous 3D T1 maps were obtained from healthy adult subjects, with a T1 value of 1476 ± 53 ms and a coefficient of variation (CV) of 6.1 ± 1.4% over the whole left-ventricular myocardium. The averaged septal T1 was 1512 ± 60 ms with a CV of 2.1 ± 0.5%.

Conclusion

Free-breathing 3D native T1 mapping at 3 T is feasible and may be applicable in myocardial assessment. The proposed 3D T1 mapping sequence is suitable for applications in which larger coverage is desired beyond that available with single-shot parametric mapping, or breath-holding is unfeasible.
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