Introduction
Methods
Animals
Data acquisition
Data pre-processing
Image registration
Analysis
Infarct area 0 % IT | All healthy tissue. IT = 0 % (includes 0 % only) |
Infarct area 0–25 % IT | IT > 0 % to IT < or = 25 % (does not include 0 % and includes 25 %) |
Infarct area 25–50 % IT | IT > 25 % to IT < or = 50 % (does not include 25 % and includes 50 %) |
Infarct area 50–75 % IT | IT > 50 % to IT < or = 75 % (does not include 50 % and includes 75 %) |
Infarct area 75–100 % IT | IT > 75 % to IT < or = 100 % (does not include 75 % and includes 100 %) |
Statistics
Results
Animals
LV end-diastolic volume (ml) | 123.6 ± 32.6 | |||
LV end-systolic volume (ml) | 72.8 ± 26.4 | |||
LV stroke volume (ml) | 50.7 ± 11.5 | |||
LV ejection fraction (%) | 42.0 ± 8.7 | |||
LV ejection fraction (%) per model (p = 0.05) | 35.7 ± 3.9 | (Model 1) | 43.3 ± 9 | (Model 2) |
Heart rate | 92.7 ± 20.7 | |||
Myocardium volume (ml) | 111 ± 15.6 | |||
Infarct volume (ml) | 15.6 ± 4.1 | |||
Infarct volume (ml) per model (p = 0.75) | 16.1 ± 2.2 | (Model 1) | 15.5 ± 4.4 | (Model 2) |
LV area (cm2) | 102.7 ± 13.8 | |||
Infarct area 0 % IT (cm2) | 68.2 ± 12.8 | (66.1 ± 6.1 %) | ||
Infarct area 0–25 % IT (cm2) | 10.6 ± 3.2 | (10.5 ± 3.3 %) | ||
Infarct area 25–50 % IT (cm2) | 6.5 ± 3.5 | (6.3 ± 3.4 %) | ||
Infarct area 50–75 % IT (cm2) | 6.4 ± 2.2 | (6.4 ± 2.6 %) | ||
Infarct area 75–100 % IT (cm2) | 10.9 ± 7.3 | (10.5 ± 6.3 %) | ||
Infarct areas (cm2) per model | ||||
Infarct area 0 % IT (cm2) (p = 0.72) | 72.6 ± 22.1 | (Model 1) | 67.3 ± 10.9 | (Model 2) |
Infarct area 0–25 % IT (cm2) (p = 0.54) | 12.4 ± 4.8 | (Model 1) | 10.2 ± 2.9 | (Model 2) |
Infarct area 25–50 % IT (cm2) (p = 0.24) | 10.2 ± 4.5 | (Model 1) | 5.7 ± 2.9 | (Model 2) |
Infarct area 50–75 % IT (cm2) (p = 0.88) | 3.7 ± 3.7 | (Model 1) | 11.7 ± 6.5 | (Model 2) |
Infarct area 75–100 % IT (cm2) (p = 0.38) | 3.8 ± 3.9 | (Model 1) | 12.4 ± 6.7 | (Model 2) |
Data acquisition
Electromechanical mapping points | ||||
Total number of EMM points | 2867 | |||
EMM points used for registration | 2590 | |||
Points per animal | 152.3 ± 55 | |||
Registration error (mm) | 3.01 ± 1.94 | |||
Registration error (mm) per model (p = 0.32) | 3.22 ± 1.87 | (Model 1) | 3.0 ± 1.82 | (Model 2) |
Points used for projection and analysis | ||||
Total number of EMM points | 1581 | |||
Points per animal | 93 ± 27.2 | |||
Points per infarct transmurality area used for projection and analysis | ||||
0 % IT | 50.2 ± 18.4 | 0.7 ± 0.3 points/cm2
| ||
0–25 % IT | 9.7 ± 6.2 | 0.9 ± 0.5 points/cm2
| ||
25–50 % IT | 8.0 ± 4.3 | 1.4 ± 0.7 points/cm2
| (p < 0.05) | |
50–75 % IT | 6.3 ± 5.6 | 0.9 ± 0.6 points/cm2
| ||
75–100 % IT | 18.7 ± 14.2 | 1.5 ± 0.8 points/cm2
|
Image registration
Analysis
Parameter | R2 (%) |
---|---|
UV | 15 |
BV | 10 |
LLS | 3 |