Erschienen in:

11.07.2018 | Case Report

Three renal failure cases successfully treated with ombitasvir/paritaprevir/ritonavir for genotype 1b hepatitis C virus reinfection after liver transplantation

verfasst von: Noriaki Orita, Tetsuro Shimakami, Hajime Sunagozaka, Rika Horii, Kouki Nio, Tekeshi Terashima, Noriho Iida, Masaaki Kitahara, Hajime Takatori, Kazunori Kawaguchi, Kazuya Kitamura, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko

Erschienen in: Clinical Journal of Gastroenterology | Ausgabe 1/2019

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Abstract

We report three cases of genotype 1b hepatitis C virus (HCV) reinfection after liver transplantation. When antiviral treatment was considered, all three patients had renal dysfunction and had been treated with immunosuppressive agents for a long time; one with tacrolimus (TAC) and the others with cyclosporine A (CyA). Therefore, the possible antiviral regimens among direct-acting antivirals (DAA) were limited and so we treated all three patients with ombitasvir/paritaprevir/ritonavir (OBV/PTV/r). Because ritonavir is known to markedly increase the blood concentration of TAC and CyA through drug–drug interactions, close monitoring of blood concentrations of TAC or CyA and dose adjustments of immunosuppressive agents were needed. Sustained virus response was achieved in all the patients treated, and there were no adverse effects or transplant rejection. OBV/PTV/r might be a useful DAA regimen for patients with genotype 1 HCV reinfection in the setting of renal dysfunction.

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Titel: Three renal failure cases successfully treated with ombitasvir/paritaprevir/ritonavir for genotype 1b hepatitis C virus reinfection after liver transplantation
verfasst von: Noriaki Orita
Tetsuro Shimakami
Hajime Sunagozaka
Rika Horii
Kouki Nio
Tekeshi Terashima
Noriho Iida
Masaaki Kitahara
Hajime Takatori
Kazunori Kawaguchi
Kazuya Kitamura
Kuniaki Arai
Taro Yamashita
Yoshio Sakai
Tatsuya Yamashita
Eishiro Mizukoshi
Masao Honda
Shuichi Kaneko
Publikationsdatum: 11.07.2018
Verlag: Springer Japan
Erschienen in: Clinical Journal of Gastroenterology / Ausgabe 1/2019
Print ISSN: 1865-7257
Elektronische ISSN: 1865-7265
DOI: https://doi.org/10.1007/s12328-018-0884-y

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Three renal failure cases successfully treated with ombitasvir/paritaprevir/ritonavir for genotype 1b hepatitis C virus reinfection after liver transplantation

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