nach oben

Erschienen in:

16.01.2022 | Research Letter

Thyroid hormone treatment and SARS-CoV-2 infection

verfasst von: Efthymia Pappa, Pagona Gourna, Georgios Galatas, Asimina Romiou, Ifigeneia Kiki, Lemonia Panagiotou, Constantinos Christopoulos

Erschienen in: Endocrine | Ausgabe 2/2022

Einloggen, um Zugang zu erhalten

Excerpt

It has recently been reported that the incidence of COVID-19 might be higher in people who are on thyroid hormone substitution treatment (THS) with levothyroxine [1]. The significance of such an association is obvious, given that levothyroxine is one of the most prescribed medications worldwide (currently the second most prescribed drug in the USA) [2]. Based on experimental evidence from animal models of coronavirus disease, it has been speculated that thyroid hormones propagate cellular internalization and replication of SARS-Cov-2 through interaction with plasma membrane integrins [3]. …

A. Bacle, Y. Malledant, M. Mercerolle, C. Pronier, N. Nesseler, C. Barbazan, R. Garlantezec, Thyroid substitution may be a risk factor for Covid-19. Endocrine 73(3), 507–508 (2021). https://doi.org/10.1007/s12020-021-02791-1CrossRefPubMed

S.P. Kane, ClinCalc DrugStats Database. https://clincalc.com/DrugStats/ (2021) Accessed November 2021.

P.J. Davis, H.Y. Lin, A. Hercbergs, K.A. Keating, S.A. Mousa, Coronaviruses and Integrin αvβ3: does thyroid hormone modify the relationship? Endocr. Res. 45(3), 210–215 (2020). https://doi.org/10.1080/07435800.2020.1767127CrossRefPubMed

S. Livadas, C. Bothou, I. Androulakis, A. Boniakos, N. Angelopoulos, L. Duntas, Levothyroxine replacement therapy and overuse: a timely diagnostic approach. Thyroid 28, 1580–1586 (2018). https://doi.org/10.1089/thy.2018.0014CrossRef

M. van Gerwen, M. Alsen, C. Little, J. Barlow, L. Naymagon, D. Tremblay, C.F. Sinclair, E. Genden, Outcomes of patients with hypothyroidism and COVID-19: A Retrospective Cohort Study. Front. Endocrinol. 11, 565 (2020). https://doi.org/10.3389/fendo.2020.00565CrossRef

T.H. Brix, L. Hegedüs, J. Hallas, L.C. Lund, Risk and course of SARS-CoV-2 infection in patients treated for hypothyroidism and hyperthyroidism. Lancet Diabetes Endocrinol. 9(4), 197–199 (2021). https://doi.org/10.1016/S2213-8587(21)00028-0CrossRefPubMedPubMedCentral

S.Y. Kim, D.M. Yoo, C.Y. Min, H.G. Choi, The effects of previous thyroid disease on the susceptibility to, morbidity of, and mortality due to COVID-19: A Nationwide Cohort Study in South Korea. J. Clin. Med. 10(16), 3522 (2021). https://doi.org/10.3390/jcm10163522CrossRefPubMedPubMedCentral

M. Bhargava, M.R. Runyon, D. Smirnov, J. Lei, T.J. Groppoli, C.N. Mariash, O.D. Wangensteen, D.H. Ingbar, Triiodo-L-thyronine rapidly stimulates alveolar fluid clearance in normal and hyperoxia-injured lungs. Am. J. Respiratory Crit. Care Med. 178(5), 506–512 (2008). https://doi.org/10.1164/rccm.200709-1429OCCrossRef

G. Yu, A. Tzouvelekis, R. Wang, J.D. Herazo-Maya, G.H. Ibarra, A. Srivastava, J. de Castro, G. DeIuliis, F. Ahangari, T. Woolard, N. Aurelien, R. Arrojo E Drigo, Y. Gan, M. Graham, X. Liu, R.J. Homer, T.S. Scanlan, P. Mannam, P.J. Lee, E.L. Herzog, A.C. Bianco, N. Kaminski, Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nat. Med. 24(1), 39–49 (2018). https://doi.org/10.1038/nm.4447CrossRefPubMed

10.

R. Baldelli, E. Nicastri, N. Petrosillo, L. Marchioni, A. Gubbiotti, I. Sperduti, P. Di Giacinto, L. Rizza, F. Rota, M. Franco, A. Lania, G. Aimaretti, G. Ippolito, P. Zuppi, Thyroid dysfunction in COVID-19 patients. J. Endocrinological Investig. 44(12), 2735–2739 (2021). https://doi.org/10.1007/s40618-021-01599-0CrossRef

11.

S. Lang, Y. Liu, X. Qu, R. Lu, W. Fu, W. Zhang, H. Wang, T. Hong, Association between thyroid function and prognosis of COVID-19: A Retrospective Observational Study. Endocr. Res. 46(4), 170–177 (2021). https://doi.org/10.1080/07435800.2021.1924770CrossRefPubMed

12.

J. Gong, D.K. Wang, H. Dong, Q.S. Xia, Z.Y. Huang, Y. Zhao, X. Chen, F. Yuan, J.B. Li, F.E. Lu, Prognostic significance of low TSH concentration in patients with COVID-19 presenting with non-thyroidal illness syndrome. BMC Endocr. Disord. 21(1), 111 (2021). https://doi.org/10.1186/s12902-021-00766-xCrossRefPubMedPubMedCentral

13.

F. Beltrão, D. Beltrão, G. Carvalhal, F. Beltrão, A. Brito, K. Capistrano, I. Bastos, F. Hecht, C. Daltro, A.C. Bianco, M. Gonçalves, H.E. Ramos, Thyroid hormone levels during hospital admission inform disease severity and mortality in COVID-19 Patients. Thyroid 31(11), 1639–1649 (2021). https://doi.org/10.1089/thy.2021.0225CrossRefPubMed

14.

University of Minnesota: Phase II randomized, intervention versus non-intervention, multi-center study of the effects of thyroid hormone (T3) on Extravascular Lung Water (EVLW) in Subjects With Acute Respiratory Distress Syndrome (ARDS). NCT04115514. https://clinicaltrials.gov/ct2/show/NCT04115514/ (2021). Accessed November 2021.

15.

K. Galioto, J. Olson, Experimental therapy may speed COVID recovery. Star Tribune. https://www.startribune.com/hormone-boost-could-be-covid-19-key/572944532 (2020). Accessed November 2021.

Titel: Thyroid hormone treatment and SARS-CoV-2 infection
verfasst von: Efthymia Pappa
Pagona Gourna
Georgios Galatas
Asimina Romiou
Ifigeneia Kiki
Lemonia Panagiotou
Constantinos Christopoulos
Publikationsdatum: 16.01.2022
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 2/2022
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-021-02957-x

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Thyroid hormone treatment and SARS-CoV-2 infection

Excerpt

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin

Springer Medizin

Excerpt

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2022

Low prevalence of diabetic retinopathy in patients with long-term type 1 diabetes and current good glycemic control - one-center retrospective assessment

The genetic polymorphisms of key genes in WNT pathway (LRP5 and AXIN1) was associated with osteoporosis susceptibility in Chinese Han population

Spontaneous extracapsular parathyroid adenoma hemorrhage: when surgery is required?

Quantitative T1 mapping MRI for the assessment of extraocular muscle fibrosis in thyroid-associated ophthalmopathy

Risk factors of skip lateral cervical lymph node metastasis in papillary thyroid carcinoma: a systematic review and meta-analysis

18F-Fluorocholine-PET combined with contrast-enhanced CT for localizing hyperfunctioning parathyroid glands and optimizing surgical treatment in patients with hyperparathyroidism

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin