Erschienen in:
22.06.2020 | Original Article
Ticagrelor Versus Clopidogrel in Patients with Late or Very Late Stent Thrombosis
verfasst von:
Jinying Zhou, Yu Tan, Chen Liu, Peng Zhou, Zhaoxue Sheng, Jiannan Li, Runzhen Chen, Hanjun Zhao, Li Song, Hongbing Yan
Erschienen in:
Cardiovascular Drugs and Therapy
|
Ausgabe 5/2020
Einloggen, um Zugang zu erhalten
Abstract
Purpose
To compare the effect of ticagrelor with clopidogrel in reducing the risk of ischemic cardiovascular events in patients with late or very late stent thrombosis (LST/VLST) after primary percutaneous coronary intervention (PCI).
Methods
A total of 4538 patients with acute coronary syndrome were screened for angiographically determined LST/VLST. Two hundred and forty-one patients were included in the analysis and grouped according to ticagrelor (n = 81) or clopidogrel (n = 160) at discharge. The clinical outcome was major adverse cardiovascular events (MACE) defined as death, myocardial infarction (MI), ischemic stroke, and revascularization during the 1-yr follow-up period.
Results
After propensity score matching, 65 pairs were generated. The incidence of MACE was significantly lower in the ticagrelor group compared with the clopidogrel group (9.3% vs. 21.5%, log-rank p = 0.048). However, no difference was observed in event rates of death, MI, ischemic stroke, and revascularization between the ticagrelor group and the clopidogrel group.
Conclusion
Following successful primary PCI, patients with LST/VLST who received ticagrelor had fewer ischemic cardiovascular events at 1-yr follow-up, compared with those who received clopidogrel.