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Erschienen in: Clinical and Experimental Medicine 3/2018

26.05.2018 | Original Article

Tight correlation between FoxM1 and FoxP3+ Tregs in gastric cancer and their clinical significance

verfasst von: Xiaoxiao Li, Kai Ma, Shanai Song, Fangzhen Shen, Tao Kuang, Yingqian Zhu, Zimin Liu

Erschienen in: Clinical and Experimental Medicine | Ausgabe 3/2018

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Abstract

The aim of the present study was to investigate the expression of Forkhead box transcription M1 (FoxM1) and Forkhead box transcription P3 (FoxP3) in gastric cancer tissues in order to reveal any correlation between FoxM1, FoxP3 and clinicopathological parameters. Their clinical significance in gastric cancer was also investigated. Immunohistochemistry was used to detect the expression of FoxM1 and FoxP3 in gastric cancer and para-cancer tissues. The clinical significance of FoxM1 and FoxP3 in gastric cancer was explored, and the association between FoxM1 and FoxP3 was further analyzed. As a result, the overexpression of FoxM1 and FoxP3 was evident in gastric cancer (P < 0.001). FoxM1 overexpression was showed to be correlated with late AJCC stage (P = 0.025), while positive tumoral FoxP3 expression was associated with deeper invasion (P = 0.020), lymph node metastasis (P = 0.019) and later AJCC stage (P = 0.024). Overexpression of FoxM1 or FoxP3 was revealed to be negative prognostic factors for survival duration (P < 0.05), whereas only FoxM1 was shown to be independently associated with prognosisin gastric cancer after multivariate analysis (P = 0.020). A significant and positive correlation between FoxM1 and FoxP3 expressions was finally confirmed (P = 0.001). This significantly positive correlation between FoxM1 and FoxP3 prompts that FoxM1 may induce immune inhibition by recruiting FoxP3+ Tregs, leading to the progression of carcinogenesis, invasion and metastasis.
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Metadaten
Titel
Tight correlation between FoxM1 and FoxP3+ Tregs in gastric cancer and their clinical significance
verfasst von
Xiaoxiao Li
Kai Ma
Shanai Song
Fangzhen Shen
Tao Kuang
Yingqian Zhu
Zimin Liu
Publikationsdatum
26.05.2018
Verlag
Springer International Publishing
Erschienen in
Clinical and Experimental Medicine / Ausgabe 3/2018
Print ISSN: 1591-8890
Elektronische ISSN: 1591-9528
DOI
https://doi.org/10.1007/s10238-018-0505-6

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