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Erschienen in: Critical Care 5/2010

01.10.2010 | Commentary

Tight glycemic control: what do we really know, and what should we expect?

verfasst von: Stanley A Nasraway Jr, Rishi Rattan

Erschienen in: Critical Care | Ausgabe 5/2010

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Abstract

Tight glycemic control has engendered large numbers of investigations, with conflicting results. The world has largely embraced intensive insulin as a practice, but applies this therapy with great variability in the manner of glucose control and measurement. The present commentary reviews what we actually know with certainty from this vast sea of literature, and what we can expect looking forward.
Literatur
1.
Zurück zum Zitat Chase JG, Pretty CG, Pfeifer L, Shaw GM, Preiser J-C, Le Compte AJ, Lin J, Hewett D, Moorhead KT, Desaive T: Organ failure and tight glycemic control in the SPRINT study. Crit Care 2010, 14: R154. 10.1186/cc9224PubMedCentralCrossRefPubMed Chase JG, Pretty CG, Pfeifer L, Shaw GM, Preiser J-C, Le Compte AJ, Lin J, Hewett D, Moorhead KT, Desaive T: Organ failure and tight glycemic control in the SPRINT study. Crit Care 2010, 14: R154. 10.1186/cc9224PubMedCentralCrossRefPubMed
2.
Zurück zum Zitat Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in critically ill patients. N Engl J Med 2001, 345: 1359-1367. 10.1056/NEJMoa011300CrossRefPubMed Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in critically ill patients. N Engl J Med 2001, 345: 1359-1367. 10.1056/NEJMoa011300CrossRefPubMed
3.
Zurück zum Zitat Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R: Intensive insulin therapy in the medical ICU. N Engl J Med 2006, 354: 449-461. 10.1056/NEJMoa052521CrossRefPubMed Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R: Intensive insulin therapy in the medical ICU. N Engl J Med 2006, 354: 449-461. 10.1056/NEJMoa052521CrossRefPubMed
4.
Zurück zum Zitat Krinsley JS: Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 2004, 79: 992-1000. 10.4065/79.8.992CrossRefPubMed Krinsley JS: Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 2004, 79: 992-1000. 10.4065/79.8.992CrossRefPubMed
5.
Zurück zum Zitat Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K: Intensive insulin therapy and pentastarch resuscitation for severe sepsis. N Engl J Med 2008, 358: 125-139. 10.1056/NEJMoa070716CrossRefPubMed Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K: Intensive insulin therapy and pentastarch resuscitation for severe sepsis. N Engl J Med 2008, 358: 125-139. 10.1056/NEJMoa070716CrossRefPubMed
6.
Zurück zum Zitat Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Dellomo R, Cook D, Dodek P, Henderson WR, Hébert PC, Heritier S, Heyland DK, McArthur C, McDonald E, Mitchell I, Myburgh JA, Norton R, Potter J, Robinson BG, Ronco JJ: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009, 360: 1283-1297. 10.1056/NEJMoa0810625CrossRefPubMed Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Dellomo R, Cook D, Dodek P, Henderson WR, Hébert PC, Heritier S, Heyland DK, McArthur C, McDonald E, Mitchell I, Myburgh JA, Norton R, Potter J, Robinson BG, Ronco JJ: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009, 360: 1283-1297. 10.1056/NEJMoa0810625CrossRefPubMed
7.
Zurück zum Zitat Treggiara MM, Karir V, Yanez ND, Weiss NS, Daniel S, Deem SA: Intensive insulin therapy and mortality in critically ill patients. Crit Care 2008, 12: R29. 10.1186/cc6807CrossRef Treggiara MM, Karir V, Yanez ND, Weiss NS, Daniel S, Deem SA: Intensive insulin therapy and mortality in critically ill patients. Crit Care 2008, 12: R29. 10.1186/cc6807CrossRef
8.
Zurück zum Zitat Annane D, Carlou A, Maxime V, Azoulay E, D'honneur G, Timsit JF, Cohen Y, Wolf M, Fartoukh M, Adrie C, Santré C, Bollaert PE, Mathonet A, Amathieu R, Tabah A, Clec'h C, Mayaud J, Lejeune J, Chevret S: Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial. JAMA 2010, 303: 341-348. 10.1001/jama.2010.516CrossRefPubMed Annane D, Carlou A, Maxime V, Azoulay E, D'honneur G, Timsit JF, Cohen Y, Wolf M, Fartoukh M, Adrie C, Santré C, Bollaert PE, Mathonet A, Amathieu R, Tabah A, Clec'h C, Mayaud J, Lejeune J, Chevret S: Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial. JAMA 2010, 303: 341-348. 10.1001/jama.2010.516CrossRefPubMed
9.
Zurück zum Zitat De la Rosa GDC, Donado JH, Restrepo AH, Quintero AM, González LG, Saldarriaga NE, Bedoya M, Toro JM, Velásquez JB, Valencia JC, Arango CM, Aleman PH, Vasquez EM, Chavarriaga JC, Yepes A, Pulido W, Cadavid CA: Strict glycaemic control in patients hospitalized in a mixed medical and surgical intensive care unit: a randomized clinical trial. Crit Care 2008, 12: R120. 10.1186/cc7017PubMedCentralCrossRef De la Rosa GDC, Donado JH, Restrepo AH, Quintero AM, González LG, Saldarriaga NE, Bedoya M, Toro JM, Velásquez JB, Valencia JC, Arango CM, Aleman PH, Vasquez EM, Chavarriaga JC, Yepes A, Pulido W, Cadavid CA: Strict glycaemic control in patients hospitalized in a mixed medical and surgical intensive care unit: a randomized clinical trial. Crit Care 2008, 12: R120. 10.1186/cc7017PubMedCentralCrossRef
10.
Zurück zum Zitat Preiser JC, Devos P, Ruiz-Santana S, Mélot C, Annane D, Groeneveld J, Iapichino G, Leverve X, Nitenberg G, Singer P, Wernerman J, Joannidis M, Stecher A, Chioléro R: A prospective randomized multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study. Intensive Care Med 2009, 35: 1738-1748. 10.1007/s00134-009-1585-2CrossRefPubMed Preiser JC, Devos P, Ruiz-Santana S, Mélot C, Annane D, Groeneveld J, Iapichino G, Leverve X, Nitenberg G, Singer P, Wernerman J, Joannidis M, Stecher A, Chioléro R: A prospective randomized multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study. Intensive Care Med 2009, 35: 1738-1748. 10.1007/s00134-009-1585-2CrossRefPubMed
11.
Zurück zum Zitat Chase JG, Shaw G, Le Compte A, Lonergan T, Willacy M, Wong XW, Lin J, Lotz T, Lee D, Hann C: Implementation and evaluation of the SPRINT protocol for tight glycaemic control in critically ill patients: a clinical practice change. Crit Care 2008, 12: R49. 10.1186/cc6868PubMedCentralCrossRefPubMed Chase JG, Shaw G, Le Compte A, Lonergan T, Willacy M, Wong XW, Lin J, Lotz T, Lee D, Hann C: Implementation and evaluation of the SPRINT protocol for tight glycaemic control in critically ill patients: a clinical practice change. Crit Care 2008, 12: R49. 10.1186/cc6868PubMedCentralCrossRefPubMed
12.
Zurück zum Zitat Nasraway SA: Sepsis research: we must change course. Crit Care Med 1999, 27: 427-430. 10.1097/00003246-199902000-00054CrossRefPubMed Nasraway SA: Sepsis research: we must change course. Crit Care Med 1999, 27: 427-430. 10.1097/00003246-199902000-00054CrossRefPubMed
13.
Zurück zum Zitat Falciglia M, Freyberg RW, Almenoff PL, D'Alessio DA, Render ML: Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. Crit Care Med 2009, 37: 3001-3009. 10.1097/CCM.0b013e3181b083f7PubMedCentralCrossRefPubMed Falciglia M, Freyberg RW, Almenoff PL, D'Alessio DA, Render ML: Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. Crit Care Med 2009, 37: 3001-3009. 10.1097/CCM.0b013e3181b083f7PubMedCentralCrossRefPubMed
14.
Zurück zum Zitat Griesdale DEG, de Souza RJ, van Dam RM, Heyland DK, Cook DJ, Malhotra A, Dhaliwal R, Henderson WR, Chittock DR, Finfer S, Talmor D: Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. Can Med Assoc J 2009, 180: 821-827. 10.1503/cmaj.090206CrossRef Griesdale DEG, de Souza RJ, van Dam RM, Heyland DK, Cook DJ, Malhotra A, Dhaliwal R, Henderson WR, Chittock DR, Finfer S, Talmor D: Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. Can Med Assoc J 2009, 180: 821-827. 10.1503/cmaj.090206CrossRef
15.
Zurück zum Zitat Finney SJ, Zekveld C, Elia A, Evans TW: Glucose control and mortality in critically ill patients. JAMA 2003, 31: 634-635. Finney SJ, Zekveld C, Elia A, Evans TW: Glucose control and mortality in critically ill patients. JAMA 2003, 31: 634-635.
16.
Zurück zum Zitat Juneja R, Roudebush CP, Nasraway SA, Golas AA, Jacobi J, Carroll J, Nelson D, Abad VJ, Flanders SJ: Computerized intensive insulin dosing can mitigate hypoglycemia and achieve tight glycemic control when glucose measurement is performed frequently and on time. Crit Care 2009, 13: R163. 10.1186/cc8129PubMedCentralCrossRefPubMed Juneja R, Roudebush CP, Nasraway SA, Golas AA, Jacobi J, Carroll J, Nelson D, Abad VJ, Flanders SJ: Computerized intensive insulin dosing can mitigate hypoglycemia and achieve tight glycemic control when glucose measurement is performed frequently and on time. Crit Care 2009, 13: R163. 10.1186/cc8129PubMedCentralCrossRefPubMed
17.
Zurück zum Zitat Kanji S, Buffie J, Hutton B, Bunting PS, Singh A, McDonald K, Fergusson D, McIntyre LA, Hebert PC: Reliability of point-of-care testing for glucose measurement in critically ill adults. Crit Care Med 2005, 33: 2778-2785. 10.1097/01.CCM.0000189939.10881.60CrossRefPubMed Kanji S, Buffie J, Hutton B, Bunting PS, Singh A, McDonald K, Fergusson D, McIntyre LA, Hebert PC: Reliability of point-of-care testing for glucose measurement in critically ill adults. Crit Care Med 2005, 33: 2778-2785. 10.1097/01.CCM.0000189939.10881.60CrossRefPubMed
19.
Zurück zum Zitat Cook CB, Abad V, Kongable G, Hanseon Y, McMahon D: The status of glucose control in U.S. intensive care units [abstract]. Crit Care Med 2008, 36: sA68. 10.1097/CCM.0b013e31817c00b0CrossRef Cook CB, Abad V, Kongable G, Hanseon Y, McMahon D: The status of glucose control in U.S. intensive care units [abstract]. Crit Care Med 2008, 36: sA68. 10.1097/CCM.0b013e31817c00b0CrossRef
Metadaten
Titel
Tight glycemic control: what do we really know, and what should we expect?
verfasst von
Stanley A Nasraway Jr
Rishi Rattan
Publikationsdatum
01.10.2010
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 5/2010
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9236

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