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09.09.2017 | Original Article

Tingenone, a pentacyclic triterpene, induces peripheral antinociception due to cannabinoid receptors activation in mice

verfasst von: C. C. Veloso, R. C. M. Ferreira, V. G. Rodrigues, L. P. Duarte, A. Klein, I. D. Duarte, T. R. L. Romero, A. C. Perez

Erschienen in: Inflammopharmacology | Ausgabe 1/2018

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Abstract

Several works have shown that triterpenes induce peripheral antinociception by activation of cannabinoid receptors and endocannabinoids; besides, several research groups have reported activation of cannabinoid receptors in peripheral antinociception. The aim of this study was to assess the involvement of the cannabinoid system in the antinociceptive effect induced by tingenone against hyperalgesia evoked by prostaglandin E₂ (PGE₂) at peripheral level. The paw pressure test was used and the hyperalgesia was induced by intraplantar injection of PGE₂ (2 μg/paw). All drugs were injected subcutaneously in the hind paws of male Swiss mice. Tingenone (200 µg/paw) administered into the right hind paw induced a local antinociceptive effect, that was antagonized by AM630, a selective antagonist to CB₂ cannabinoid receptor. AM251, a selective antagonist to CB₁ cannabinoid receptor, did not alter the peripheral antinociceptive effect of tingenone. MAFP, a fatty acid amide hydrolase (FAAH) inhibitor; VDM11, an anandamide reuptake inhibitor; and JZL184, monoacylglycerol lipase (MAGL) inhibitor did not potentiate the peripheral antinociceptive effect of the lower dose of tingenone (50 µg/paw). The results suggest that tingenone induced a peripheral antinociceptive effect via cannabinoid receptor activation. Therefore, this study suggests a pharmacological potential for a new analgesic drug.

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Titel: Tingenone, a pentacyclic triterpene, induces peripheral antinociception due to cannabinoid receptors activation in mice
verfasst von: C. C. Veloso
R. C. M. Ferreira
V. G. Rodrigues
L. P. Duarte
A. Klein
I. D. Duarte
T. R. L. Romero
A. C. Perez
Publikationsdatum: 09.09.2017
Verlag: Springer International Publishing
Erschienen in: Inflammopharmacology / Ausgabe 1/2018
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-017-0391-7

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Tingenone, a pentacyclic triterpene, induces peripheral antinociception due to cannabinoid receptors activation in mice

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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