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Erschienen in: Pediatric Cardiology 4/2008

01.07.2008 | Original Article

Tissue Doppler-Derived Diastolic Myocardial Velocities Are Abnormal in Pediatric Cardiac Transplant Recipients in the Absence of Endomyocardial Rejection

verfasst von: Sebastian Strigl, Rose Hardy, Julie S. Glickstein, Daphne T. Hsu, Linda J. Addonizio, Jacqueline M. Lamour, Ashwin Prakash

Erschienen in: Pediatric Cardiology | Ausgabe 4/2008

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Abstract

The aim of this study was to evaluate diastolic function in pediatric cardiac transplant recipients free of acute rejection using tissue Doppler. E′ and A′ velocities at the mitral, septal, and tricuspid annuli in 31 pediatric heart transplant recipients free of acute rejection were compared with 28 controls and with previously published pediatric normative data. E′ velocities were lower in the transplant group at the mitral (0.13 ± 0.04 vs. 0.2 ± 0.04 m/s, p < 0.0001), septal (0.1 ± 0.03 vs. 0.14 ± 0.03 m/s, p = 0.001), and tricuspid annuli (0.1 ± 0.04 vs. 0.17 ± 0.04 m/s, p < 0.0001). A′ velocities were also lower in the transplant group at the septal (0.04 ± 0.01 vs. 0.06 ± 0.01 m/s, p = 0.001) and tricuspid annuli (0.06 ± 0.02 vs. 0.1 ± 0.03 m/s, p < 0.00001). E′ and A′ were abnormally low at the mitral annulus in 31% and 13%, septal annulus in 50% and 21%, and tricuspid annulus in 63% and 36% of the subjects, respectively. Abnormalities in tissue Doppler-derived diastolic myocardial velocities are common in pediatric cardiac transplant recipients free of acute rejection.
Literatur
1.
Zurück zum Zitat Abali G, Tokgozoglu L, Ozcebe OI, Aytemir K, Nazli N (2005) Which Doppler parameters are load independent? A study in normal volunteers after blood donation. J Am Soc Echocardiogr 18:1260–1265PubMedCrossRef Abali G, Tokgozoglu L, Ozcebe OI, Aytemir K, Nazli N (2005) Which Doppler parameters are load independent? A study in normal volunteers after blood donation. J Am Soc Echocardiogr 18:1260–1265PubMedCrossRef
2.
Zurück zum Zitat Asante-Korang A, Fickey M, Boucek MM, Boucek RJ (2004) Diastolic performance assessed by tissue Doppler after pediatric heart transplantation. J Heart Lung Transplant 23:865–872PubMedCrossRef Asante-Korang A, Fickey M, Boucek MM, Boucek RJ (2004) Diastolic performance assessed by tissue Doppler after pediatric heart transplantation. J Heart Lung Transplant 23:865–872PubMedCrossRef
3.
Zurück zum Zitat Cardim N, Oliveira AG, Longo S, et al. (2003) Doppler tissue imaging: regional myocardial function in hypertrophic cardiomyopathy and in athlete’s heart. J Am Soc Echocardiogr 16:223–232PubMedCrossRef Cardim N, Oliveira AG, Longo S, et al. (2003) Doppler tissue imaging: regional myocardial function in hypertrophic cardiomyopathy and in athlete’s heart. J Am Soc Echocardiogr 16:223–232PubMedCrossRef
4.
Zurück zum Zitat Eidem BW, McMahon CJ, Cohen RR, et al. (2004) Impact of cardiac growth on Doppler tissue imaging velocities: a study in healthy children. J Am Soc Echocardiogr 17:212–221PubMedCrossRef Eidem BW, McMahon CJ, Cohen RR, et al. (2004) Impact of cardiac growth on Doppler tissue imaging velocities: a study in healthy children. J Am Soc Echocardiogr 17:212–221PubMedCrossRef
5.
Zurück zum Zitat Fyfe DA, Ketchum D, Lewis R, et al. (2006) Tissue Doppler imaging detects severely abnormal myocardial velocities that identify children with pre-terminal cardiac graft failure after heart transplantation. [Abstract]. J Heart Lung Transplant 25:510–517PubMedCrossRef Fyfe DA, Ketchum D, Lewis R, et al. (2006) Tissue Doppler imaging detects severely abnormal myocardial velocities that identify children with pre-terminal cardiac graft failure after heart transplantation. [Abstract]. J Heart Lung Transplant 25:510–517PubMedCrossRef
6.
Zurück zum Zitat Fyfe DA, Mahle WT, Kanter KR, Wu G, Vincent RN, Ketchum DL (2003) Reduction of tricuspid annular Doppler tissue velocities in pediatric heart transplant patients. J Heart Lung Transplant 22:553–559PubMedCrossRef Fyfe DA, Mahle WT, Kanter KR, Wu G, Vincent RN, Ketchum DL (2003) Reduction of tricuspid annular Doppler tissue velocities in pediatric heart transplant patients. J Heart Lung Transplant 22:553–559PubMedCrossRef
7.
Zurück zum Zitat Galiuto L, Ignone G, DeMaria AN (1998) Contraction and relaxation velocities of the normal left ventricle using pulsed-wave tissue Doppler echocardiography. Am J Cardiol 81:609–614PubMedCrossRef Galiuto L, Ignone G, DeMaria AN (1998) Contraction and relaxation velocities of the normal left ventricle using pulsed-wave tissue Doppler echocardiography. Am J Cardiol 81:609–614PubMedCrossRef
8.
Zurück zum Zitat Heidenreich PA, Hancock SL, Vagelos RH, Lee BK, Schnittger I (2005) Diastolic dysfunction after mediastinal irradiation. Am Heart J 150:977–982PubMedCrossRef Heidenreich PA, Hancock SL, Vagelos RH, Lee BK, Schnittger I (2005) Diastolic dysfunction after mediastinal irradiation. Am Heart J 150:977–982PubMedCrossRef
9.
Zurück zum Zitat Ho CY, Sweitzer NK, McDonough B, et al. (2002) Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy. Circulation 105:2992–2997PubMedCrossRef Ho CY, Sweitzer NK, McDonough B, et al. (2002) Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy. Circulation 105:2992–2997PubMedCrossRef
10.
Zurück zum Zitat Hsiao SH, Huang WC, Sy CL, Lin SK, Lee TY, Liu CP (2005) Doppler tissue imaging and color M-mode flow propagation velocity: are they really preload independent? J Am Soc Echocardiogr 18:1277–1284PubMedCrossRef Hsiao SH, Huang WC, Sy CL, Lin SK, Lee TY, Liu CP (2005) Doppler tissue imaging and color M-mode flow propagation velocity: are they really preload independent? J Am Soc Echocardiogr 18:1277–1284PubMedCrossRef
11.
Zurück zum Zitat Nagueh SF, Bachinski LL, Meyer D, et al. (2001) Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy. Circulation 104:128–130PubMed Nagueh SF, Bachinski LL, Meyer D, et al. (2001) Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy. Circulation 104:128–130PubMed
12.
Zurück zum Zitat Nagueh SF, Middleton KJ, Kopelen HA, Zoghbi WA, Quinones MA (1997) Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol 30:1527–1533PubMedCrossRef Nagueh SF, Middleton KJ, Kopelen HA, Zoghbi WA, Quinones MA (1997) Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol 30:1527–1533PubMedCrossRef
13.
Zurück zum Zitat Nagueh SF, Sun H, Kopelen HA, Middleton KJ, Khoury DS (2001) Hemodynamic determinants of the mitral annulus diastolic velocities by tissue Doppler. J Am Coll Cardiol 37:278–285PubMedCrossRef Nagueh SF, Sun H, Kopelen HA, Middleton KJ, Khoury DS (2001) Hemodynamic determinants of the mitral annulus diastolic velocities by tissue Doppler. J Am Coll Cardiol 37:278–285PubMedCrossRef
14.
Zurück zum Zitat Nikitin NP, Witte KK, Thackray SD, de Silva R, Clark AL, Cleland JG (2003) Longitudinal ventricular function: normal values of atrioventricular annular and myocardial velocities measured with quantitative two-dimensional color Doppler tissue imaging. J Am Soc Echocardiogr 16:906–921PubMedCrossRef Nikitin NP, Witte KK, Thackray SD, de Silva R, Clark AL, Cleland JG (2003) Longitudinal ventricular function: normal values of atrioventricular annular and myocardial velocities measured with quantitative two-dimensional color Doppler tissue imaging. J Am Soc Echocardiogr 16:906–921PubMedCrossRef
15.
Zurück zum Zitat Oki T, Tabata T, Yamada H, Wakatsuki T, et al. (1997) Clinical application of pulsed Doppler tissue imaging for assessing abnormal left ventricular relaxation. Am J Cardiol 79:921–928PubMedCrossRef Oki T, Tabata T, Yamada H, Wakatsuki T, et al. (1997) Clinical application of pulsed Doppler tissue imaging for assessing abnormal left ventricular relaxation. Am J Cardiol 79:921–928PubMedCrossRef
16.
Zurück zum Zitat Ommen SR, Nishimura RA, Appleton CP, et al. (2000) Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: a comparative simultaneous Doppler-catheterization study. Circulation 102:1788–1794PubMed Ommen SR, Nishimura RA, Appleton CP, et al. (2000) Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: a comparative simultaneous Doppler-catheterization study. Circulation 102:1788–1794PubMed
17.
Zurück zum Zitat Pauliks LB, Pietra BA, Kirby S, et al. (2005) Altered ventricular mechanics in cardiac allografts: a tissue Doppler study in 30 children without prior rejection history. J Heart Lung Transplant 24:1804–1813PubMedCrossRef Pauliks LB, Pietra BA, Kirby S, et al. (2005) Altered ventricular mechanics in cardiac allografts: a tissue Doppler study in 30 children without prior rejection history. J Heart Lung Transplant 24:1804–1813PubMedCrossRef
18.
Zurück zum Zitat Prakash A, Printz BF, Lamour JM, Addonizio LJ, Glickstein JS (2004) Myocardial performance index in pediatric patients after cardiac transplantation. J Am Soc Echocardiogr 17:439–442PubMedCrossRef Prakash A, Printz BF, Lamour JM, Addonizio LJ, Glickstein JS (2004) Myocardial performance index in pediatric patients after cardiac transplantation. J Am Soc Echocardiogr 17:439–442PubMedCrossRef
19.
Zurück zum Zitat Sohn DW, Chai IH, Lee DJ, et al. (1997) Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol 30:474–480PubMedCrossRef Sohn DW, Chai IH, Lee DJ, et al. (1997) Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol 30:474–480PubMedCrossRef
20.
Zurück zum Zitat Tumuklu MM, Erkorkmaz U, Ocal A (2007) The impact of hypertension and hypertension-related left ventricle hypertrophy on right ventricle function. Echocardiography 24:374–384PubMedCrossRef Tumuklu MM, Erkorkmaz U, Ocal A (2007) The impact of hypertension and hypertension-related left ventricle hypertrophy on right ventricle function. Echocardiography 24:374–384PubMedCrossRef
Metadaten
Titel
Tissue Doppler-Derived Diastolic Myocardial Velocities Are Abnormal in Pediatric Cardiac Transplant Recipients in the Absence of Endomyocardial Rejection
verfasst von
Sebastian Strigl
Rose Hardy
Julie S. Glickstein
Daphne T. Hsu
Linda J. Addonizio
Jacqueline M. Lamour
Ashwin Prakash
Publikationsdatum
01.07.2008
Verlag
Springer-Verlag
Erschienen in
Pediatric Cardiology / Ausgabe 4/2008
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI
https://doi.org/10.1007/s00246-007-9188-6

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