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Clinical and Translational Oncology

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01.05.2015 | Research Article

Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma

verfasst von: M. Askari, M. Darabi, R. Zare Mahmudabadi, M. Oboodiat, S. Fayezi, Z. Mostakhdemin Hosseini, A. Pirzadeh

Erschienen in: Clinical and Translational Oncology | Ausgabe 5/2015

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Abstract

Purpose

Oral squamous cell carcinoma (OSCC) is a remarkable health problem worldwide, but its pathogenesis remains unknown. The aim of this study was to compare fat composition and secretory phospholipase-A2 (sPLA2) activity between the malignant and adjacent normal squamous tissues in patients with OSCC.

Methods

Paired samples of malignant squamous and adjacent normal-appearing tissues were collected from 27 patients with OSCC. The fatty acid composition in the obtained tissues was determined by gas liquid chromatography. Tissue enzyme activities of sPLA2 were measured using the standard assay with Diheptanoyl Thio-Phosphatidylcholine as substrate.

Results

In the OSCC tissue, the level of stearic acid (18:0) and activity of sPLA2 were higher (P < 0.001), and the levels of oleic acid (18:1n-9) and linoleic acid (18:2n-6) were lower than that in the adjacent normal-appearing squamous tissue (P < 0.001). The activity of sPLA2 in OSCC was strongly negatively correlated with the amount of 18:2n-6 (r = −0.41, P < 0.001). Negative significant associations were observed between the OSCC invasion and tissue levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHE).

Conclusion

The changes in the fatty acid composition and sPLA2 activity may be regarded as indicators of altered lipid metabolism occurring in vivo during squamous cell carcinogenesis.

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Titel: Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma
verfasst von: M. Askari
M. Darabi
R. Zare Mahmudabadi
M. Oboodiat
S. Fayezi
Z. Mostakhdemin Hosseini
A. Pirzadeh
Publikationsdatum: 01.05.2015
Verlag: Springer Milan
Erschienen in: Clinical and Translational Oncology / Ausgabe 5/2015
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI: https://doi.org/10.1007/s12094-014-1242-2

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23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma

Abstract

Purpose

Methods

Results

Conclusion

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ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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