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Erschienen in:

01.11.2009

Tissue Transglutaminase Can Be Involved in Airway Inflammation of Toluene Diisocyanate-Induced Occupational Asthma

verfasst von: Gyu-Young Hur, Sung-Ho Kim, Sang Myun Park, Young-Min Ye, Cheol-Woo Kim, An-Soo Jang, Choon-Sik Park, Chein Soo Hong, Hae-Sim Park

Erschienen in: Journal of Clinical Immunology | Ausgabe 6/2009

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Abstract

Background

This study was conducted to evaluate whether tissue transglutaminase (tTG) may be involved in airway inflammation of toluene diisocyanate-induced occupational asthma (TDI-OA).

Methods

We enrolled 93 patients with TDI-OA, 177 asymptomatic exposed subjects, 43 patients with allergic asthma, and 70 unexposed normal controls. The prevalence of serum immunoglobulin G (IgG) to tTG in the TDI-OA group (20.2%) was significantly higher than that in the three other groups (P < 0.001).

Results

TDI-OA patients with serum IgG to tTG had significantly lower methacholine PC₂₀ values (P < 0.02) and significantly higher prevalence of specific immunoglobulin E to vapor type TDI–human serum albumin conjugate (P < 0.01; r ² = 0.411, P < 0.05). TDI exposure could increase tTG activity via reactive oxygen species (ROS) production, which was found to cross-link with cytokeratin 19 on immunoblot analysis.

Conclusion

Therefore, TDI exposure may activate tTG via ROS-mediated mechanism in the airway epithelium leading to persistent airway inflammation in TDI-OA patients.

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Titel: Tissue Transglutaminase Can Be Involved in Airway Inflammation of Toluene Diisocyanate-Induced Occupational Asthma
verfasst von: Gyu-Young Hur
Sung-Ho Kim
Sang Myun Park
Young-Min Ye
Cheol-Woo Kim
An-Soo Jang
Choon-Sik Park
Chein Soo Hong
Hae-Sim Park
Publikationsdatum: 01.11.2009
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 6/2009
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-009-9314-8

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Tissue Transglutaminase Can Be Involved in Airway Inflammation of Toluene Diisocyanate-Induced Occupational Asthma

Abstract

Background

Methods

Results

Conclusion

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