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Erschienen in: Cardiovascular Drugs and Therapy 1/2011

01.12.2011

Tolvaptan for Heart Failure Patients with Volume Overload

verfasst von: Masatsugu Hori

Erschienen in: Cardiovascular Drugs and Therapy | Sonderheft 1/2011

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Excerpt

Edema is defined as a state of extracellular fluid accumulation, mostly of intercellular fluid, and clinically as a state where the subcutaneous tissues become enlarged because of the accumulation of interstitial fluid. Edema is often observed in daily clinical practice and the most serious causes include heart failure (HF), hepatic cirrhosis, and nephrotic syndrome. …
Literatur
2.
Zurück zum Zitat Schrier RW, Abraham WT. Hormones and hemodynamics in heart failure. N Engl J Med. 1999;341:577–85.PubMedCrossRef Schrier RW, Abraham WT. Hormones and hemodynamics in heart failure. N Engl J Med. 1999;341:577–85.PubMedCrossRef
3.
Zurück zum Zitat Goldsmith SR, Gheorghiade M. Vasopressin antagonism in heart failure. J Am Coll Cardiol. 2005;46:1785–91.PubMedCrossRef Goldsmith SR, Gheorghiade M. Vasopressin antagonism in heart failure. J Am Coll Cardiol. 2005;46:1785–91.PubMedCrossRef
4.
Zurück zum Zitat Rivera-Santos A, Star R. Sodium: volume depletion and hyponatremia. In: Seldin D, Giebisch G, editors. Diuretic agents—clinical physiology and pharmacology. San Diego: Academic; 1997. p. 559–69. Rivera-Santos A, Star R. Sodium: volume depletion and hyponatremia. In: Seldin D, Giebisch G, editors. Diuretic agents—clinical physiology and pharmacology. San Diego: Academic; 1997. p. 559–69.
5.
Zurück zum Zitat Palmer BF. Potassium disturbances associated with the use of diuretics. In: Seldin D, Giebisch G, editors. Diuretic agents—clinical physiology and pharmacology. San Diego: Academic; 1997. p. 571–83. Palmer BF. Potassium disturbances associated with the use of diuretics. In: Seldin D, Giebisch G, editors. Diuretic agents—clinical physiology and pharmacology. San Diego: Academic; 1997. p. 571–83.
6.
Zurück zum Zitat Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med. 1999;341:709–17.PubMedCrossRef Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med. 1999;341:709–17.PubMedCrossRef
7.
Zurück zum Zitat Zannad F, McMurray JJ, Krum H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. 2011;364:11–21.PubMedCrossRef Zannad F, McMurray JJ, Krum H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. 2011;364:11–21.PubMedCrossRef
9.
Zurück zum Zitat Cuffe MS, Califf RM, Adams KF, et al. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. JAMA. 2002;287:1541–7.PubMedCrossRef Cuffe MS, Califf RM, Adams KF, et al. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. JAMA. 2002;287:1541–7.PubMedCrossRef
10.
Zurück zum Zitat Kim SR, Hasunuma T, Sato O, et al. Pharmacokinetics, pharmacodynamics and safety of tolvaptan, a novel, oral, selective nonpeptide AVP V2-receptor antagonist: results of single- and multiple-dose studies in healthy Japanese male volunteers. Cardiovasc Drugs Ther. 2011; submitted. Kim SR, Hasunuma T, Sato O, et al. Pharmacokinetics, pharmacodynamics and safety of tolvaptan, a novel, oral, selective nonpeptide AVP V2-receptor antagonist: results of single- and multiple-dose studies in healthy Japanese male volunteers. Cardiovasc Drugs Ther. 2011; submitted.
11.
Zurück zum Zitat Matsuzaki M, Hori M, Izumi T, et al. Effects of tolvaptan on volume overload in Japanese patients with heart failure: Results of a phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Cardiovasc Drugs Ther. 2011; submitted. Matsuzaki M, Hori M, Izumi T, et al. Effects of tolvaptan on volume overload in Japanese patients with heart failure: Results of a phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Cardiovasc Drugs Ther. 2011; submitted.
12.
Zurück zum Zitat Matsuzaki M, Hori M, Izumi T, et al. Efficacy and safety of tolvaptan in heart failure patients with volume overload despite the standard treatment with conventional diuretics: a phase III, randomized, double-blind, placebo-controlled study (QUEST Study). Cardiovasc Drugs Ther. 2011; submitted. Matsuzaki M, Hori M, Izumi T, et al. Efficacy and safety of tolvaptan in heart failure patients with volume overload despite the standard treatment with conventional diuretics: a phase III, randomized, double-blind, placebo-controlled study (QUEST Study). Cardiovasc Drugs Ther. 2011; submitted.
13.
Zurück zum Zitat Fukunami M, Matsuzaki M, Hori M, et al. Efficacy and safety of tolvaptan in heart failure patients with sustained volume overload despite the use of conventional diuretics: a phase III open-label study. Cardiovasc Drugs Ther. 2011; submitted. Fukunami M, Matsuzaki M, Hori M, et al. Efficacy and safety of tolvaptan in heart failure patients with sustained volume overload despite the use of conventional diuretics: a phase III open-label study. Cardiovasc Drugs Ther. 2011; submitted.
14.
Zurück zum Zitat Inomata T, Izumi T, Matsuzaki M, et al. Phase III clinical pharmacology study of tolvaptan. Cardiovasc Drugs Ther. 2011; submitted. Inomata T, Izumi T, Matsuzaki M, et al. Phase III clinical pharmacology study of tolvaptan. Cardiovasc Drugs Ther. 2011; submitted.
15.
Zurück zum Zitat Onogawa T, Sakamoto Y, Nakamura S, et al. Effects of tolvaptan on systemic and renal hemodynamic function in dogs with congestive heart failure. Cardiovasc Drugs Ther. 2011; submitted. Onogawa T, Sakamoto Y, Nakamura S, et al. Effects of tolvaptan on systemic and renal hemodynamic function in dogs with congestive heart failure. Cardiovasc Drugs Ther. 2011; submitted.
16.
Zurück zum Zitat Miyazaki T, Sakamoto Y, Yamashita T, et al. Anti-edematous effects of tolvaptan in experimental rodent models. Cardiovasc Drugs Ther. 2011; submitted. Miyazaki T, Sakamoto Y, Yamashita T, et al. Anti-edematous effects of tolvaptan in experimental rodent models. Cardiovasc Drugs Ther. 2011; submitted.
17.
Zurück zum Zitat Furukawa M, Hirota M, Okumura H, et al. Nonclinical pharmacokinetics of tolvaptan. Cardiovasc Drugs Ther. 2011; submitted. Furukawa M, Hirota M, Okumura H, et al. Nonclinical pharmacokinetics of tolvaptan. Cardiovasc Drugs Ther. 2011; submitted.
18.
Zurück zum Zitat Oi A, Ito N, Morishita K, et al. Nonclinical safety profile of tolvaptan. Cardiovasc Drugs Ther. 2011; submitted. Oi A, Ito N, Morishita K, et al. Nonclinical safety profile of tolvaptan. Cardiovasc Drugs Ther. 2011; submitted.
19.
Zurück zum Zitat Yamamura Y, Nakamura S, Itoh S, et al. OPC-41061, a highly potent human vasopressin V2-receptor antagonist: pharmacological profile and aquaretic effect by single and multiple oral dosing in rats. J Pharmacol Exp Ther. 1998;287:860–7.PubMed Yamamura Y, Nakamura S, Itoh S, et al. OPC-41061, a highly potent human vasopressin V2-receptor antagonist: pharmacological profile and aquaretic effect by single and multiple oral dosing in rats. J Pharmacol Exp Ther. 1998;287:860–7.PubMed
20.
Zurück zum Zitat Miyazaki T, Fujiki H, Yamamura Y, Nakamura S, Mori T. Tolvaptan, an orally active vasopressin V(2)-receptor antagonist - pharmacology and clinical trials. Cardiovasc Drug Rev. 2007;25:1–13.PubMedCrossRef Miyazaki T, Fujiki H, Yamamura Y, Nakamura S, Mori T. Tolvaptan, an orally active vasopressin V(2)-receptor antagonist - pharmacology and clinical trials. Cardiovasc Drug Rev. 2007;25:1–13.PubMedCrossRef
21.
Zurück zum Zitat Hirano T, Yamamura Y, Nakamura S, Onogawa T, Mori T. Effects of the V(2)-receptor antagonist OPC-41061 and the loop diuretic furosemide alone and in combination in rats. J Pharmacol Exp Ther. 2000;292:288–94.PubMed Hirano T, Yamamura Y, Nakamura S, Onogawa T, Mori T. Effects of the V(2)-receptor antagonist OPC-41061 and the loop diuretic furosemide alone and in combination in rats. J Pharmacol Exp Ther. 2000;292:288–94.PubMed
22.
Zurück zum Zitat Costello-Boerrigter LC, Smith WB, Boerrigter G, et al. Vasopressin-2-receptor antagonism augments water excretion without changes in renal hemodynamics or sodium and potassium excretion in human heart failure. Am J Physiol Ren Physiol. 2006;290:F273–8.CrossRef Costello-Boerrigter LC, Smith WB, Boerrigter G, et al. Vasopressin-2-receptor antagonism augments water excretion without changes in renal hemodynamics or sodium and potassium excretion in human heart failure. Am J Physiol Ren Physiol. 2006;290:F273–8.CrossRef
Metadaten
Titel
Tolvaptan for Heart Failure Patients with Volume Overload
verfasst von
Masatsugu Hori
Publikationsdatum
01.12.2011
Verlag
Springer US
Erschienen in
Cardiovascular Drugs and Therapy / Ausgabe Sonderheft 1/2011
Print ISSN: 0920-3206
Elektronische ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-011-6298-4

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