The treatment paradigm for locally advanced rectal cancer has changed in recent years. Neoadjuvant radiochemotherapy followed by total mesorectal excision and postoperative chemotherapy has been the standard of care since many years. With this …

Diabetes mellitus is a metabolic disorder that is increasingly prevalent among women of reproductive age [ 1 ]. Maternal diabetes can be categorized into two subtypes: pre-gestational diabetes mellitus (PGDM) and gestational diabetes mellitus …

The United States lacks contemporary, publicly available, autologous oocyte assisted reproductive technology (ART) age-stratified outcome data for patients > 42 years old. After 2015, the CDC aggregated outcome data beyond age 42 or 43, depending …

Endornaviruses accumulate in their hosts as non-enveloped double-stranded RNA molecules, although it is now thought that they evolved from positive-sense RNA viruses [ 1 , 2 ]. The monopartite RNA genomes of endornaviruses encode a single …

The endometrium is the innermost layer of the uterus, which undergoes dynamic histological, physiological and molecular changes that allow it to synchronize with embryo development, facilitate embryo implantation, and ultimately, establish a …

Pregnancy is one of the most important stages of a woman’s life. Although it may be a positive experience for most pregnant women, it is often a stressful experience along with physiological and psychological changes [ 1 ]. Tensions and worries in …

During the menopausal transition, the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the pituitary increases to compensate for the declining estradiol levels due to a decrease in ovarian function. Based on changes …

Mental illness affects one in six adults [ 1 ], and accounts for 11% of the global burden of disease [ 2 ]. Mental illnesses are defined in this paper as serious psychiatric disorders characterized by “a change in cognition, emotion, or behaviour …

Pelvic fixation remains a challenging and controversial area in spine surgery. Anatomy, bone quality, and biomechanical forces are some reasons why surgeons continue to explore and study options for fixation in spinal deformity patients. Pelvic …

Large amounts of germline sequencing data have recently become available and we sought to compare these results with population-based family history data. Family studies are able to describe aggregation of any defined cancers in families. The …

Strokes impact millions of Americans and are projected to increase in prevalence by 20% over the next 10 years [ 1 , 2 ]. However, a given individual’s needs after stroke vary widely as a function of the stroke extent and location. Post-stroke …