Novel androgen receptor signal inhibitors (ARAT) and taxane-based chemotherapy are crucial agents for treating metastatic castration-resistant prostate cancer (mCRPC). Docetaxel (DTX) is commonly used as a primary chemotherapy, and cabazitaxel …

The digestive system is a major source of cancer, with colorectal cancer being the most commonly diagnosed type in Japan in the year 2019 [ 1 ]. The development of cancer chemotherapy has significantly improved the prognosis of cancer patients; …

Prophylactic pegylated granulocyte colony-stimulating factor (G-CSF) during cancer chemotherapy is typically administered on or after the day following the completion of chemotherapy (Days 2, 3, 4, or 5). No consensus has been established on which …

Lung cancer is the predominant cause of mortality in many countries [ 1 ] and presents a significant public health challenge. Most lung cancer cases are diagnosed at an advanced stage, necessitating comprehensive and systematic pharmacotherapy as …

Moyamoya disease (MMD) is a chronic occlusive cerebrovascular disease with the development of a network of abnormal vessels. Immune inflammation is associated with the occurrence and development of MMD. However, the mechanisms underlying the …

CSF (Cerebro Spinal Fluid) rhinorrhoea occurs when the fluid leaks from subarachnoid space into the nasal cavity. The study aims to find out the prevalence and demographic distribution of CSF leak and to describe the site of the CSF leak along …

Infections that are unusually severe or caused by opportunistic pathogens are a hallmark of primary immunodeficiency (PID). Anti-cytokine autoantibodies (ACA) are an emerging cause of acquired immunodeficiency mimicking PID. Nocardia spp. are …

Granulocyte colony-stimulating factor (G-CSF) decreases the incidence, duration, and severity of febrile neutropenia (FN); however, dose reduction or withdrawal is often preferred in the management of adverse events in the treatment of urothelial …

The purpose of this study is to predict the mRNA expression of CSF1R in HGG non-invasively using MRI (magnetic resonance imaging) omics technology and to evaluate the correlation between the established radiomics model and prognosis. We …

Brain metastases most commonly arise in patients with lung cancer, breast cancer, and melanoma. Brain metastases are generally associated with poor quality of life and pose distinctive clinical challenges [ 1 , 2 ]. Precision medicine and the use …

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically and clinically heterogeneous disorder with predominant neurological involvement [ 1 , 2 ]. The disease is caused by a genetic mutation in …

Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive loss of memory and cognitive functions due to continuous neuron damage and resultant increases in affected areas of the brain [ 1 ], which refers to the …

Myelodysplastic syndrome/Myeloproliferative neoplasm (MDS/MPN) overlap syndromes are recently identified entities that have been quite difficult to define due to overlapping morphological features and absence of a specific molecular abnormality.

Infektionen bei neutropenischen Patienten nach Chemotherapie manifestieren sich meistens durch Fieber (febrile Neutropenie, FN). Zu den wichtigsten Determinanten des FN-Risikos gehören der Chemotherapietyp, die Dosisintensität und …