Pregnancy loss (PL) is defined as the spontaneous demise of a pregnancy before the fetus reaches viability, which is a significant negative life event and impacts 10–15% of clinically recognized pregnancies. Recurrent pregnancy loss (RPL) refers …

Intrahepatic cholestasis during pregnancy (ICP) is a common complication of pregnancy, characterized by elevated bile acid levels, skin pruritus, and elevated transaminase levels in the second half of pregnancy. ICP can lead to complications such …

Cardiovascular disease (CVD) is one of the most common causes of maternal death and morbidity during pregnancy in developed countries, including the United States [ 1 ]. The global prevalence of pregnancy-associated heart failure (HF) has increased …

Gestational diabetes mellitus (GDM), which is defined by the World Health Organization as glucose intolerance first recognized during pregnancy, has drawn global concern [ 1 , 2 ]. The GDM incidence is alarming, affecting 14.8% of pregnant women in …

Lymphangioleiomyomatosis(LAM) is a slow progressive, rare cystic lung disease in women of reproductive age, associated with infiltration of the lung by atypical smooth muscle like cells, leading to the cystic destruction of the lung parenchyma. As …

Non-communicating rudimentary horn pregnancy (NCRHP) is an extremely rare condition, with a reported incidence of 1:76,000 to 1:150,000 with 75 to 83% of pregnancies in non-communicating uterine horn [ 1 ]. The possible mechanism for …

Uterine rupture(UR) is a serious complication that directly jeopardizes the life of the mother and the fetus [ 1 ]. It refers to the rupture of the uterine body or the lower uterine segment in late pregnancy or during labor [ 2 ], requiring a …

Fabry disease is a rare, X-linked lysosomal storage disorder. Pathogenic variants in GLA , coding for alpha-galactosidase A (E.C. 3.2.1.22), lead to enzyme deficiency resulting in glycosphingolipid deposition-related sequelae in almost all organs.

There is increasing evidence to suggest that across child bearing years, women with mental health disorders may disproportionately experience intimate partner violence (IPV), with the experiences of IPV potentially associated with impacts on their …

Long-chain marine n -3 fatty acids (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) have anti-inflammatory effects [ 1 ] and may influence the development of type 1 diabetes [ 2 ]. Studies in experimental animals and retrospective …

Maternal mortality is an important metric for determining progress in maternal care, as illustrated by Sustainable Development Goal target 3.1 which aims to reduce the global maternal mortality ratio to less than 70 per 100,000 live births [ 1 , 2 …

Monoclonal antibodies (mAbs) are an important therapeutic modality for conditions that commonly affect women of child-bearing potential, such as autoimmune disorders [ 1 ]. Although relatively little information is available on the pharmacokinetics …

Maternal pre-pregnancy obesity (Body Mass Index [BMI] ≥ 30 kg/m 2 ) has become a major challenge of obstetric care. For example, of the mothers who gave birth in Finland in 2021, 18.4% were living with obesity at the start of their pregnancy [ 1 ].

The rate of induction of labor (IOL) is increasing [ 1 ]. Nowadays, 25–30% of labors are induced [ 2 , 3 ]. The rise in induction rates is partly explained by increased obesity and maternal age [ 1 , 4 ] and by knowledge about IOL timing in …