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Toxoplasma gondii 

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  1. Open Access 01.12.2024 | OriginalPaper

    Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology

    Infectious diseases incorporate a wide range of conditions that significantly threaten the health of humans [ 26 ].. Humans are commonly infected with multiple pathogens simultaneously or consecutively, and synergistic and antagonistic pathogenic …

  2. Open Access 01.12.2024 | OriginalPaper

    Seromolecular study on the prevalence and risk factors of Toxoplasma gondii infection in pregnant women referred to a gynecology hospital in Urmia, northwest part of Iran in 2022

    Toxoplasmosis is a frequent infection among the human population. The infection can cause devastating complications for the fetus during pregnancy. The present study aimed to determine the serological and molecular prevalence of the infection and …

  3. Open Access 01.12.2024 | OriginalPaper

    Genetic diversity and seroprevalence of Toxoplasma gondii in COVID‑19 patients; a first case-control study in Iran

    Toxoplasma gondii as an intracellular parasite can infect approximately one-third of the residents worldwide [ 1 ]. Nearly, 39.3% of the population of Iran and 35.1-41% of people in the Northwest Iran are infected with toxoplasmosis [ 2 , 3 ].

  4. Open Access 01.12.2024 | OriginalPaper

    A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice

    Traumatic brain injury (TBI) is a key contributor to global morbidity that lacks effective treatments. Microbial infections are common in TBI patients, and their presence could modify the physiological response to TBI. It is estimated that …

  5. Open Access 15.12.2023 | OriginalPaper

    Genotyping of European Toxoplasma gondii strains by a new high-resolution next-generation sequencing-based method

    Toxoplasma gondii is a zoonotic protozoon that infects a large variety of warm-blooded species and can cause clinical disease in animals and humans. Felids are the definitive hosts of this parasite with sexual reproduction stage occurring only in …

  6. 21.03.2023 | ReviewPaper

    Toxoplasma gondii infections in pediatric neurosurgery

    Toxoplasma gondii is a parasite that is estimated to infect one-third of the world’s population. It is acquired by ingesting contaminated water and food specially undercooked meat, contact with domestic or wild feline feces, and during pregnancy …

  7. 15.08.2023 | OriginalPaper

    Serological and molecular detection of Toxoplasma gondii in ß. thalassemia patients

    Toxoplasma gondii is a worldwide opportunistic protozoan causing life-threatening infection in immunocompromised patients, while frequently asymptomatic in immunocompetent individuals. The current study aimed to detect T. gondii; serologically and …

  8. 26.09.2023 | OriginalPaper

    Performances of ICT Toxoplasma IgG-IgM test in comparison with Vidas® toxo competition to determine the immune status against Toxoplasma gondii

    Toxoplasmosis is a ubiquitous parasitic infection caused by Toxoplasma gondii (Tg). In immunocompetent people, the infection may be asymptomatic with the induction of an immune response that may prevent reinfection or transmission to the fetus in …

  9. Open Access 01.12.2023 | OriginalPaper

    Berberine improves inhibitory avoidance memory impairment of Toxoplasma gondii-infected rat model of ketamine-induced schizophrenia

    T. gondii is an obligate intracellular protozoan parasite that causes toxoplasmosis in a wide range of homeothermic hosts. Approximately one-third of the human population is infected by brain parasites, especially T. gondii [ 1 ]. Numerous studies …

  10. Open Access 01.12.2023 | OriginalPaper

    Prophylactic antineoplastic activity of Toxoplasma gondii RH derived antigen against ehrlich solid carcinoma with evidence of shared antigens by comparative immunoblotting

    Since immune-suppression is one of cancer hallmarks, cancer-immunotherapy has emerged as a revolutionized weapon to fight cancer [ 1 – 3 ]. Unfortunately, upon using cancer antigens in immunotherapy, an immune tolerance is induced due to the …

  11. 13.06.2023 | OriginalPaper

    The effects of intracellular iron availability on the outcome of Toxoplasma gondii infection in mice

    Toxoplasma gondii (T. gondii) is a parasite that obtains the iron it needs for its own metabolism from the host-cell iron pool. In this work, we aimed to investigate if iron supplementation or deficiency affected the course of T. gondii infection.

  12. 14.06.2023 | OriginalPaper

    Toxoplasma gondii genotyping in AIDS patients using high resolution melt analysis (HRM analysis) in Khuzestan province, southwest Iran

    Toxoplasmosis is a parasitic zoonotic disease caused by Toxoplasma gondii, a common protozoan in the Apicomplexa phylum. Several studies in Iran have demonstrated the presence of the parasite in various hosts, but no data on T. gondii genotyping …

  13. 22.06.2023 | OriginalPaper

    Ivermectin modulated cerebral γ-aminobutyric acid (GABA) and reduced the number of chronic Toxoplasma gondii cysts significantly in the brains of immunocompromised mice

    Disruption of GABAergic signaling could exaggerate the inflammatory reaction associated with Toxoplasma gondii infection, as well as produce neurophysiological consequences including seizures that occur within the brain tissues. The current study …

  14. Open Access 24.04.2023 | OriginalPaper

    A ring trial to harmonize Toxoplasma gondii microsatellite typing: comparative analysis of results and recommendations for optimization

    A ring trial among five European laboratories was organized to reach consistency in microsatellite (MS) typing of the zoonotic parasite Toxoplasma gondii. Three sample sets were circulated and analyzed by each laboratory following a previously …

  15. Open Access 01.12.2023 | OriginalPaper

    First description of congenital toxoplasmosis after maternal coinfection with Toxoplasma gondii and severe acute respiratory syndrome coronavirus 2: a case report

    Up to two billion people worldwide are infected by the protozoan parasite Toxoplasma gondii ( T. gondii ) [ 1 , 2 ]. Of these, approximately 190,100 cases per year account for congenital toxoplasmosis; and hence, this disease is considered by the …

  16. 04.02.2023 | OriginalPaper

    Toxoplasma gondii infection in patients with brain tumors in Southern Iran: a case-control study

    Considerable evidence points to a dominant role of inflammation in tumor pathology. The biological response of the immune system can be triggered by Toxoplasma gondii as a common brain-tropic parasite. The aim of this study was to investigate an …

  17. Open Access 01.05.2023 | OriginalPaper

    Toxoplasma gondii-derived antigen modifies tumor microenvironment of Ehrlich solid carcinoma murine model and enhances immunotherapeutic activity of cyclophosphamide

    Pathogen-based cancer vaccine is a promising immunotherapeutic weapon to stimulate cancer immunosuppressive state. Toxoplasma gondii is a potent immunostimulant, and low-dose infection was linked to cancer resistance. Our goal was to evaluate the …

  18. 16.01.2023 | OriginalPaper

    Serological evidence of anti-Toxoplasma gondii antibodies and haematological and serum biochemical alterations in wild rats and humans in Nigeria

    Rats serve as carriers of Toxoplasma gondii, an obligate intracellular protozoan parasite that causes a global zoonotic disease referred to as toxoplasmosis, and thus play a very important role in the epidemiology of the disease. This study …

  19. 16.11.2022 | OriginalPaper

    Prevalence and genetic characterization of Toxoplasma gondii strains isolated from 31 wild Passeriformes collected in North-Central Oklahoma

    Passerine birds are widely distributed and adapted to various habitats, therefore they are commonly exposed to, and infected with Toxoplasma gondii. The purpose of our project was to determine the prevalence and genotypes of T. gondii in 31 …

  20. 08.04.2022 | ReviewPaper

    Toxoplasma gondii vaccine candidates: a concise review

    Toxoplasma gondii is an obligate intracellular parasite that causes toxoplasmosis. It has been shown that the severity of symptoms depends on the functioning of the host immune system. Although T. gondii infection typically does not lead to severe …

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