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Current Colorectal Cancer Reports

Erschienen in:

09.10.2018 | Radiation Therapy and Radiation Therapy Innovations in Colorectal Cancer (JY Wo, Section Editor)

Total Neoadjuvant Therapy (TNT) in Rectal Cancer

verfasst von: Sarah J. Stephens, Christopher G. Willett, Manisha Palta, Brian G. Czito

Erschienen in: Current Colorectal Cancer Reports | Ausgabe 6/2018

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Abstract

Purpose of Review

This review summarizes the relevant literature on the use of total neoadjuvant therapy (TNT) for patients with locally advanced rectal cancer. It highlights the most notable literature published and briefly discusses future directions.

Recent Findings

Recent randomized trials evaluating TNT show improved rates of pathologic complete response and patient treatment tolerance with this approach.

Summary

The rationale for TNT includes the poor patient tolerance of adjuvant chemotherapy and the persistent risk of distant disease in patients with locally advanced rectal cancer, despite improvements in local control. Randomized trials have focused on short-term pathologic endpoints. Ongoing phase 3 trials are evaluating long-term disease-related outcomes, allowing for a more thorough evaluation of this treatment paradigm. TNT may also facilitate organ preservation in appropriately selected patients.

SEER Cancer Statistics [Available from: https://seer.cancer.gov/statfacts/html/colorect.html.

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Titel: Total Neoadjuvant Therapy (TNT) in Rectal Cancer
verfasst von: Sarah J. Stephens
Christopher G. Willett
Manisha Palta
Brian G. Czito
Publikationsdatum: 09.10.2018
Verlag: Springer US
Erschienen in: Current Colorectal Cancer Reports / Ausgabe 6/2018
Print ISSN: 1556-3790
Elektronische ISSN: 1556-3804
DOI: https://doi.org/10.1007/s11888-018-0415-8

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24.04.2024 | DGIM 2024 | Nachrichten

Springer Medizin

Total Neoadjuvant Therapy (TNT) in Rectal Cancer

Abstract

Purpose of Review

Recent Findings

Summary

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