nach oben

Erschienen in:

23.01.2019 | Case Report

Tracer Accumulation in Relation to Venous Thrombus on ¹⁸F-DOPA PET/CT in a Case of Persistent Hyperinsulinemic Hypoglycemia of Infancy

verfasst von: Saurabh Arora, Nishikant Avinash Damle, Averilicia Passah, Rajni Sharma, Harish Goyal, Shreedharan Thankarajan Arunraj, Priyanka Gupta, Manisha Jana

Erschienen in: Nuclear Medicine and Molecular Imaging | Ausgabe 2/2019

Einloggen, um Zugang zu erhalten

Abstract

¹⁸F-DOPA PET/CT is commonly done in patients with persistent hyperinsulinemic hypoglycemia of infancy (PHHI) to look for any focal lesion in the pancreas. We present the findings in a 20-day-old neonate with PHHI who underwent ¹⁸F-DOPA PET/CT. The scan showed diffuse uptake in the pancreas with no focal lesion, physiologic excretion into the genito-urinary system, and interestingly tracer accumulation was seen in the inferior vena cava and ilio-femoral veins which is a non-physiological site for tracer accumulation. The uptake corresponded to a large venous thrombus which was confirmed by a venous Doppler.

Sann L. Neonatal hypoglycemia. Biol Neonate. 1990;58:16–21.CrossRefPubMed

Hawdon JM, Ward Platt MP, Aynsley-Green A. Prevention and management of neonatal hypoglycemia. Arch Dis Child. 1994;70:60–4.CrossRef

Land JM. Hypoglycemia in the neonate: how and when is it important? Dev Neurosci. 1994;16:307–12.CrossRefPubMed

Kahler SG. Metabolic disorders associated with neonatal hypoglycemia. NeoReviews. 2004;5:377–81.CrossRef

Capito C, Khen-Dunlop N, Ribeiro MJ, et al. Value of 18F-fluoro-L-dopa PET in the preoperative localization of focal lesions in congenital hyperinsulinism. Radiology. 2009;253:216–22.CrossRefPubMed

Lee Y. Current developments in imaging for deep vein thrombosis. Hong Kong Med J. 2015;21:96–7.CrossRefPubMed

Prandoni P, Piccioli A. Venous thromboembolism and cancer: a two-way clinical association. Front Biosci. 1997;2:12–20.CrossRef

Hessov I, Bojsen-Møller M, Melsen F. Experimental infusion thrombophlebitis. A comparison between glucose and frutcose and 5% and 10% glucose solution. Intensive Care Med. 1979;5:79–81.CrossRefPubMed

Lowe GD. Virchow’s triad revisited: abnormal flow. Pathophysiol Haemost Thromb. 2003;33:455–7.CrossRefPubMed

10.

Houshmand S, Salavati A, Hess S, et al. The role of molecular imaging in diagnosis of deep vein thrombosis. Am J Nucl Med Mol Imaging. 2014;4:406–25.PubMedPubMedCentral

11.

Miceli M, Atoui R, Walker R, et al. Diagnosis of deep septic thrombophlebitis in cancer patients by fluorine-18 fluorodeoxyglucose positron emission tomography scanning: a preliminary report. J Clin Oncol. 2004;22:1949–56.CrossRefPubMed

12.

Meintjes M, Endozo R, Dickson J, et al. 18F-DOPA PET and enhanced CT imaging for congenital hyperinsulinism: initial UK experience from a technologist’s perspective. Nucl Med Commun. 2013;34:601.CrossRefPubMed

13.

Garnett ES, Firnau G, Nahmias C. Dopamine visualized in the basal ganglia of living man. Nature. 1983;305:137–8.CrossRefPubMed

14.

Youland RS, Kitange GJ, Peterson TE, et al. The role of LAT1 in (18)F-DOPA uptake in malignant gliomas. J Neuro-Oncol. 2013;111:11–8.CrossRef

Titel: Tracer Accumulation in Relation to Venous Thrombus on 18F-DOPA PET/CT in a Case of Persistent Hyperinsulinemic Hypoglycemia of Infancy
verfasst von: Saurabh Arora
Nishikant Avinash Damle
Averilicia Passah
Rajni Sharma
Harish Goyal
Shreedharan Thankarajan Arunraj
Priyanka Gupta
Manisha Jana
Publikationsdatum: 23.01.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Nuclear Medicine and Molecular Imaging / Ausgabe 2/2019
Print ISSN: 1869-3474
Elektronische ISSN: 1869-3482
DOI: https://doi.org/10.1007/s13139-018-00568-5

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Tracer Accumulation in Relation to Venous Thrombus on ¹⁸F-DOPA PET/CT in a Case of Persistent Hyperinsulinemic Hypoglycemia of Infancy

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2019

Development of Predictive Models in Patients with Epiphora Using Lacrimal Scintigraphy and Machine Learning

Progress of Coordination and Utilization of Zirconium-89 for Positron Emission Tomography (PET) Studies

Promotion of Nuclear Medicine-Related Sciences in Developing Countries

Perspective in Nuclear Theranostics Using Exosome for the Brain

Gallbladder Paraganglioma Associated with SDHD Mutation: a Potential Pitfall on 18F-FDOPA PET Imaging

Theranostics in India: a Particularly Exquisite Concept or an Experimental Tool