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Erschienen in: Brain Structure and Function 4/2022

23.03.2022 | Original Article

Tracing in vivo the dorsal loop of the optic radiation: convergent perspectives from tractography and electrophysiology compared to a neuroanatomical ground truth

verfasst von: Rizzi Michele, Sartori Ivana, Del Vecchio Maria, Berta Luca, Lizio Domenico, Zauli Flavia Maria, De Benedictis Alessandro, Sarubbo Silvio, Al-Orabi Khalid, Mariani Valeria, Avanzini Pietro

Erschienen in: Brain Structure and Function | Ausgabe 4/2022

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Abstract

The temporo-parietal junction (TPJ) is a cortical area contributing to a multiplicity of visual, language-related, and cognitive functions. In line with this functional richness, also the organization of the underlying white matter is highly complex and includes several bundles. The few studies tackling the outcome and neurological burdens of surgical operations addressing TPJ document the presence of language disturbances and visual field damages, with the latter hardly recovered in time. This observation advocates for identifying and functionally monitoring the optic radiation (OR) bundles that cross the white matter below the TPJ. In the present study, we adopted a multimodal approach to address the anatomo-functional correlates of the OR’s dorsal loop. In particular, we combined cadavers’ dissection with tractographic and electrophysiological data collected in drug-resistant epileptic patients explored by stereoelectroencephalography (SEEG). Cadaver dissection allowed us to appreciate the course and topography of the dorsal loop. More surprisingly, both tractographic and electrophysiological observations converged on a unitary picture highly coherent with the data obtained by neuroanatomical observation. The combination of diverse and multimodal observations allows overcoming the limitations intrinsic to single methodologies, defining a unitary picture which makes it possible to investigate the dorsal loop both presurgically and at the individual patient level, ultimately contributing to limit the postsurgical damages. Notwithstanding, such a combined approach could serve as a model of investigation for future neuroanatomical inquiries tackling white matter fibers anatomy and function through SEEG-derived neurophysiological data.
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Metadaten
Titel
Tracing in vivo the dorsal loop of the optic radiation: convergent perspectives from tractography and electrophysiology compared to a neuroanatomical ground truth
verfasst von
Rizzi Michele
Sartori Ivana
Del Vecchio Maria
Berta Luca
Lizio Domenico
Zauli Flavia Maria
De Benedictis Alessandro
Sarubbo Silvio
Al-Orabi Khalid
Mariani Valeria
Avanzini Pietro
Publikationsdatum
23.03.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
Brain Structure and Function / Ausgabe 4/2022
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-021-02430-5

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