Skip to main content
Erschienen in:

18.07.2023 | Traditionelle chinesische Medizin | Zertifizierte Fortbildung

Gastroösophageale Refluxerkrankung (GERD) aus Sicht der westlichen Medizin und aus der Perspektive der Traditionellen Chinesischen Medizin (TCM)

verfasst von: Ute Giuliani

Erschienen in: Chinesische Medizin / Chinese Medicine | Ausgabe 2/2023

zum CME-Kurs Einloggen, um Zugang zu erhalten

Zusammenfassung

Die gastroösophageale Refluxerkrankung (GERD) ist eine häufige Volkskrankheit, die ca. 40 % der Weltbevölkerung betrifft. Die GERD beschränkt die Lebensqualität (QoL), ist häufig mit einer Dauerverordnung und potenziellen Neben‑/Wechselwirkungen von Protonenpumpenhemmern (PPI) verbunden und weist einen relevanten gesundheitsökonomischen Aspekt auf. Patienten fragen immer wieder nach Alternativen zu PPI, westlich gibt es keine adäquate symptomlindernde Option.
Die Traditionelle Chinesische Medizin (TCM) mit ihrer mehr als 2000-jährigen Erfahrung und Bewährung bietet sich als wirksame komplementäre Option an. Nach der aktuellen Studienlage ist bei GERD eine additive Akupunktur zur westlichen Therapie mit PPI zu befürworten. Akupunktur in Kombination mit westlicher Standardtherapie führt zu einer besseren Symptomreduktion und kann v. a. bei PPI-refraktären Patienten eine gute Option sein. Akupunktur und chinesische Phytotherapie zeigen bei der GERD-Behandlung keine schweren unerwünschten Nebenwirkungen. Chinesische Phytotherapie führt zu einer Symptomreduktion bei GERD und weist einen besseren Langzeiteffekt auf als PPI. Die Evidenz für TCM-Phytotherapie bei GERD ist jedoch gering. Die Studien weisen größtenteils ein schlechtes Studiendesign und geringe Fallzahlen auf. Zudem arbeitet die TCM mit individuellen Therapiekonzepten entsprechend der chinesischen Diagnose. Bei dieser Heterogenität der Patientengruppen ist die TCM nicht für westliche evidenzbasierte Medizin (EBM) geeignet. Eine Option wären hier westliche randomisierte kontrollierte Studien (RCT) nach dem Vorbild der in China durchgeführten „TCM-Syndrom-Studien“, die die Patientengruppen entsprechend der gleichen chinesischen Diagnose randomisieren.
Nach der untersuchten Studienlage bleibt TCM bei GERD eine erfahrungsbasierte Medizin. Bei geringem Nebenwirkungsprofil und positiven Trends in den Studien kann jedoch den PPI-refraktären GERD-Patienten und den Patienten mit nicht erosiver Refluxkrankheit (NERD) mit psychischer Komorbidität TCM als wirksame Option empfohlen werden.
Literatur
Zurück zum Zitat Allampati S, Lopez R, Thota P. Use of a positional therapy device significantly improves nocturnal gastroesophageal reflux symptoms. Dis Esophagus. 2017;30(3):1–7.PubMed Allampati S, Lopez R, Thota P. Use of a positional therapy device significantly improves nocturnal gastroesophageal reflux symptoms. Dis Esophagus. 2017;30(3):1–7.PubMed
Zurück zum Zitat Bajbouj M, Becker V, Philip V. High-dose esomeprazole for treatment of symptomatic refractory gastroesophageal reflux disease—a prospective pH metry/impedance-controlled study. Digestion. 2009;80:112–8.PubMed Bajbouj M, Becker V, Philip V. High-dose esomeprazole for treatment of symptomatic refractory gastroesophageal reflux disease—a prospective pH metry/impedance-controlled study. Digestion. 2009;80:112–8.PubMed
Zurück zum Zitat Becher A, El-Serag H. Systematic review: the association between symptomatic response to proton pump inhibitors and health-related quality of life in patients with gastro oesophageal reflux disease. Aliment Pharmacol Ther. 2011;34:618–27.PubMed Becher A, El-Serag H. Systematic review: the association between symptomatic response to proton pump inhibitors and health-related quality of life in patients with gastro oesophageal reflux disease. Aliment Pharmacol Ther. 2011;34:618–27.PubMed
Zurück zum Zitat Chen W. 50 case clinical observation of the use of Juan Ni Yin decoction in the treatment of reflux esophagitis with liver and stomach constraint heat. Jiangsu J Tradit Chin Med. 2015;47:3. Chen W. 50 case clinical observation of the use of Juan Ni Yin decoction in the treatment of reflux esophagitis with liver and stomach constraint heat. Jiangsu J Tradit Chin Med. 2015;47:3.
Zurück zum Zitat Chen P, Cui X. Effect of Banxia Houpu decoction with Zuo Jin pills in the treatment of 42 cases of NERD. China J Guang Ming Chin Med. 2010;25:7. Chen P, Cui X. Effect of Banxia Houpu decoction with Zuo Jin pills in the treatment of 42 cases of NERD. China J Guang Ming Chin Med. 2010;25:7.
Zurück zum Zitat Cheng Y, Zhang X‑I, Wang G, et al. Influence of Shugan Hewei Decoction on periphery esophageal visceral sensitivity in non-erosive gastroesophageal reflux disease model rats. Liaoning J Tradit Chin Med. 2012;39:11. Cheng Y, Zhang X‑I, Wang G, et al. Influence of Shugan Hewei Decoction on periphery esophageal visceral sensitivity in non-erosive gastroesophageal reflux disease model rats. Liaoning J Tradit Chin Med. 2012;39:11.
Zurück zum Zitat Chi M. A clinical study on the efficacy of Yun Shugan San in the treatment of non-erosive reflux disease. Zhejiang J Tradit Chin Med. 2009;44:10. Chi M. A clinical study on the efficacy of Yun Shugan San in the treatment of non-erosive reflux disease. Zhejiang J Tradit Chin Med. 2009;44:10.
Zurück zum Zitat Dallemagne B, Weertz J, Markiewics S, et al. Clinical results of laparoscopic fundoplication ten years after surgery. Surg Endosc. 2006;20:159–65.PubMed Dallemagne B, Weertz J, Markiewics S, et al. Clinical results of laparoscopic fundoplication ten years after surgery. Surg Endosc. 2006;20:159–65.PubMed
Zurück zum Zitat Dent J, Brun J, Frederick A. An evidence-based appraisal of reflux disease management—the Genval Workshop Report. Gut. 1999;44(Suppl 2):1–16. Dent J, Brun J, Frederick A. An evidence-based appraisal of reflux disease management—the Genval Workshop Report. Gut. 1999;44(Suppl 2):1–16.
Zurück zum Zitat DeVault K, Castell D. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol. 2005;100(1):190–200.PubMed DeVault K, Castell D. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol. 2005;100(1):190–200.PubMed
Zurück zum Zitat Dickman R, Schiff E, Holland A, et al. Clinical trial: acupuncture vs. doubling the proton pump inhibitor dose in refractory heartburn. Aliment Pharmacol Ther. 2007;27(10):1333–44. Dickman R, Schiff E, Holland A, et al. Clinical trial: acupuncture vs. doubling the proton pump inhibitor dose in refractory heartburn. Aliment Pharmacol Ther. 2007;27(10):1333–44.
Zurück zum Zitat Ee HC, Li GY, et al. GERD: an alternative perspective. Psychosomatics. 2016;57:142–51. Review Article. Ee HC, Li GY, et al. GERD: an alternative perspective. Psychosomatics. 2016;57:142–51. Review Article.
Zurück zum Zitat El-Serag H, Becher A, Jones R. Systematic review: persistent reflux symptoms on proton pump inhibitor therapy in primary care and community studies. Aliment Pharmacol Ther. 2010;32:720–37.PubMed El-Serag H, Becher A, Jones R. Systematic review: persistent reflux symptoms on proton pump inhibitor therapy in primary care and community studies. Aliment Pharmacol Ther. 2010;32:720–37.PubMed
Zurück zum Zitat El-Serag H, Sweet S, Winchester C, Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014;63(6):871–80.PubMed El-Serag H, Sweet S, Winchester C, Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014;63(6):871–80.PubMed
Zurück zum Zitat Engelhardt U. Skript Block 13c: Chinesische Diätetik. München: Carl-Hermann Hempen; 2018. Engelhardt U. Skript Block 13c: Chinesische Diätetik. München: Carl-Hermann Hempen; 2018.
Zurück zum Zitat Fass R, Sontag S, Traxler B, Sostek M. Treatment of patients with persistent heartburn symptoms: a double-blind, randomized trial. Clin Gastroenterol Hepatol. 2006;4:50–6.PubMed Fass R, Sontag S, Traxler B, Sostek M. Treatment of patients with persistent heartburn symptoms: a double-blind, randomized trial. Clin Gastroenterol Hepatol. 2006;4:50–6.PubMed
Zurück zum Zitat Hamada A, Ishii J, Doi K, et al. Increased risk of exacerbating gastrointestinal disease among elderly patients following treatment with calcium channel blockers. J Clin Pharm Ther. 2008;33(6):619–24.PubMed Hamada A, Ishii J, Doi K, et al. Increased risk of exacerbating gastrointestinal disease among elderly patients following treatment with calcium channel blockers. J Clin Pharm Ther. 2008;33(6):619–24.PubMed
Zurück zum Zitat Hattori T, Fujitsuka N, Asakawa A, Inui A. A strategy using Rikkunshito (Liu-Jun-Zi-Tang), a Japanese traditional medicine, to treat gastrointestinal disease. In: Basics of evidence based herbal medicine. Kerala: Research Signpost Press; 2010. S. 149–60. Hattori T, Fujitsuka N, Asakawa A, Inui A. A strategy using Rikkunshito (Liu-Jun-Zi-Tang), a Japanese traditional medicine, to treat gastrointestinal disease. In: Basics of evidence based herbal medicine. Kerala: Research Signpost Press; 2010. S. 149–60.
Zurück zum Zitat Hempel H, Abraham N, El-Serag H. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med. 2005;145:199–211. Hempel H, Abraham N, El-Serag H. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med. 2005;145:199–211.
Zurück zum Zitat Hempen C‑H. Skript Block 19b: Magen-Darm-Erkrankungen. München: Carl-Hermann Hempen; 2019. Hempen C‑H. Skript Block 19b: Magen-Darm-Erkrankungen. München: Carl-Hermann Hempen; 2019.
Zurück zum Zitat Herold G. Innere Medizin. Köln: Arzt + Information; 2018. S. 436–40. Herold G. Innere Medizin. Köln: Arzt + Information; 2018. S. 436–40.
Zurück zum Zitat Hungin P, Hill C, Molloy-Bland M, Raghunath A. Systematic review: patterns of proton pump inhibitor use and adherence in gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2012;10:109–16.PubMed Hungin P, Hill C, Molloy-Bland M, Raghunath A. Systematic review: patterns of proton pump inhibitor use and adherence in gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2012;10:109–16.PubMed
Zurück zum Zitat Ip S, Tatsioni A, Conant A. Predictors of clinical outcomes following fundoplication for gastroesophageal reflux disease remain insufficiently defined: a systematic review. Am J Gastroenterol. 2009;104:752–8.PubMed Ip S, Tatsioni A, Conant A. Predictors of clinical outcomes following fundoplication for gastroesophageal reflux disease remain insufficiently defined: a systematic review. Am J Gastroenterol. 2009;104:752–8.PubMed
Zurück zum Zitat Iwakiri K, Kinoshita Y, Habu Y. Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015. J Gastroenterol. 2016;51:751–67.PubMed Iwakiri K, Kinoshita Y, Habu Y. Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015. J Gastroenterol. 2016;51:751–67.PubMed
Zurück zum Zitat Johnson T, Gerson L, Hershcovici T. Systematic review: the effects of carbonated beverages on gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2010;31:607–14.PubMed Johnson T, Gerson L, Hershcovici T. Systematic review: the effects of carbonated beverages on gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2010;31:607–14.PubMed
Zurück zum Zitat Kaltenbach T, Crockett S, Gerson L. Are lifestyle measures effective in patients with gastroesophageal reflux disease? An evidence-based approach. Arch Intern Med. 2006;166:965–71.PubMed Kaltenbach T, Crockett S, Gerson L. Are lifestyle measures effective in patients with gastroesophageal reflux disease? An evidence-based approach. Arch Intern Med. 2006;166:965–71.PubMed
Zurück zum Zitat Kamolz T, Granderath F, Pointner R. Does major depression in patients with gastroesophageal reflux disease affect the outcome of laparoscopic antireflux surgery? Surg Endosc. 2003;17:55–60.PubMed Kamolz T, Granderath F, Pointner R. Does major depression in patients with gastroesophageal reflux disease affect the outcome of laparoscopic antireflux surgery? Surg Endosc. 2003;17:55–60.PubMed
Zurück zum Zitat Katz P, Gerson L, Vela M. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108:308–28.PubMed Katz P, Gerson L, Vela M. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108:308–28.PubMed
Zurück zum Zitat Koop H, Fuchs K, Labenz J. S2k guideline: gastroesophageal reflux disease guided by the German Society of Gastroenterology: AWMR register no. 021-013. Z Gastroenterol. 2014;52:1299–346.PubMed Koop H, Fuchs K, Labenz J. S2k guideline: gastroesophageal reflux disease guided by the German Society of Gastroenterology: AWMR register no. 021-013. Z Gastroenterol. 2014;52:1299–346.PubMed
Zurück zum Zitat Kuyumcu S. Erkrankungen des Ösophagus. In: Lüscher T, Steffel J, Hrsg. Magen-Darm-Trakt. Berlin Heidelberg: Springer; 2013. S. 47–56. Kuyumcu S. Erkrankungen des Ösophagus. In: Lüscher T, Steffel J, Hrsg. Magen-Darm-Trakt. Berlin Heidelberg: Springer; 2013. S. 47–56.
Zurück zum Zitat Labenz J. Leitlinie Gastroösophageale Refluxkrankheit 2022: Was ist neu? MMW Fortschr Med. 2022;18:40–4. Labenz J. Leitlinie Gastroösophageale Refluxkrankheit 2022: Was ist neu? MMW Fortschr Med. 2022;18:40–4.
Zurück zum Zitat Labenz J, Feußner H. Therapieresistente Refluxkrankheit. Gastroenterologe. 2009;4:393–402. Labenz J, Feußner H. Therapieresistente Refluxkrankheit. Gastroenterologe. 2009;4:393–402.
Zurück zum Zitat Li Z, Xiao G, Chen Y. Correlation studies between TCM syndromes and psychological factors in gastroesophageal reflux disease. Jiangsu J Tradit Chin Med. 2009;41:7. Li Z, Xiao G, Chen Y. Correlation studies between TCM syndromes and psychological factors in gastroesophageal reflux disease. Jiangsu J Tradit Chin Med. 2009;41:7.
Zurück zum Zitat Ling W, Li Y, Jiang W, et al. Common mechanism of pathogenesis in gastrointestinal diseases implied by consistent efficacy of single Chinese medicine formula: a PRISMA-compliant systematic review and meta-analysis. Medicine. 2015;94(27):e1111.PubMedPubMedCentral Ling W, Li Y, Jiang W, et al. Common mechanism of pathogenesis in gastrointestinal diseases implied by consistent efficacy of single Chinese medicine formula: a PRISMA-compliant systematic review and meta-analysis. Medicine. 2015;94(27):e1111.PubMedPubMedCentral
Zurück zum Zitat Liu W, Wang Z, Han W, Xia Z. Epidemiology studies of TCM syndromes in gastroesophageal reflux disease. Beijing J Tradit Chin Med. 2008;27:4. Liu W, Wang Z, Han W, Xia Z. Epidemiology studies of TCM syndromes in gastroesophageal reflux disease. Beijing J Tradit Chin Med. 2008;27:4.
Zurück zum Zitat Locke GR 3rd, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112(5):1448–56.PubMed Locke GR 3rd, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112(5):1448–56.PubMed
Zurück zum Zitat Lund I, Lundeberg T. Are minimal, superficial or sham acupuncture procedures acceptable as inert placebo controls? Acupunct Med. 2006;24:13–5.PubMed Lund I, Lundeberg T. Are minimal, superficial or sham acupuncture procedures acceptable as inert placebo controls? Acupunct Med. 2006;24:13–5.PubMed
Zurück zum Zitat Lundell L, Dent J, Bennett J, et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut. 1999;45(2):172–80.PubMedPubMedCentral Lundell L, Dent J, Bennett J, et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut. 1999;45(2):172–80.PubMedPubMedCentral
Zurück zum Zitat Luo Y. Spezielle Erkrankungen des Verdauungssystems. Beijing: Volksverlag für Hygiene Beijing; 2005. Luo Y. Spezielle Erkrankungen des Verdauungssystems. Beijing: Volksverlag für Hygiene Beijing; 2005.
Zurück zum Zitat Ma Y, Hu X. Clinical research of gastroesophageal reflux treated with Shiguankang granule. Tianjin J Tradit Chin Med. 2013;30(3):138–41. Ma Y, Hu X. Clinical research of gastroesophageal reflux treated with Shiguankang granule. Tianjin J Tradit Chin Med. 2013;30(3):138–41.
Zurück zum Zitat Mainie I, Tutuian R, Shay S, et al. Acid and nonacid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring. Gut. 2006;55(10):1398–402.PubMedPubMedCentral Mainie I, Tutuian R, Shay S, et al. Acid and nonacid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring. Gut. 2006;55(10):1398–402.PubMedPubMedCentral
Zurück zum Zitat Martinez-Serna T, Tercero F, Filipi C, et al. Symptom priority ranking in the care of gastroesophageal reflux: a review of 1,850 cases. Dig Dis. 1999;17(4):219–24.PubMed Martinez-Serna T, Tercero F, Filipi C, et al. Symptom priority ranking in the care of gastroesophageal reflux: a review of 1,850 cases. Dig Dis. 1999;17(4):219–24.PubMed
Zurück zum Zitat Mogami S, Hattori T. Beneficial effects of Rikkunshito, a Japanese Kampo medicine, on gastrointestinal dysfunction and anorexia in combination with western drug: a systematic review. Evid Based Complement Alternat Med. 2014;2014:519035.PubMedPubMedCentral Mogami S, Hattori T. Beneficial effects of Rikkunshito, a Japanese Kampo medicine, on gastrointestinal dysfunction and anorexia in combination with western drug: a systematic review. Evid Based Complement Alternat Med. 2014;2014:519035.PubMedPubMedCentral
Zurück zum Zitat Ness-Jensen E, Lindam A, Lagergren J, Hyeem K. Weight loss and reduction in gastroesophageal reflux. A prospective population-based cohort study: The HUNT study. Am J Gastroenterol. 2013;108:376–82.PubMed Ness-Jensen E, Lindam A, Lagergren J, Hyeem K. Weight loss and reduction in gastroesophageal reflux. A prospective population-based cohort study: The HUNT study. Am J Gastroenterol. 2013;108:376–82.PubMed
Zurück zum Zitat Nordenstedt H, Zheng Z, Cameron A, et al. Postmenopausal hormone therapy as a risk factor for gastroesophageal reflux symptoms among female twins. Gastroenterology. 2008;134(4):921–8.PubMed Nordenstedt H, Zheng Z, Cameron A, et al. Postmenopausal hormone therapy as a risk factor for gastroesophageal reflux symptoms among female twins. Gastroenterology. 2008;134(4):921–8.PubMed
Zurück zum Zitat Pandolfino J, El-Serag H, Zhang Q. Obesity: a challenge to esophagogastric junction integrity. Gastroenterology. 2006;130:639–49.PubMed Pandolfino J, El-Serag H, Zhang Q. Obesity: a challenge to esophagogastric junction integrity. Gastroenterology. 2006;130:639–49.PubMed
Zurück zum Zitat Pandolfino J, Kwiatek M, Kahrilas P. The pathophysiologic basis for epidemiologic trends in gastroesophageal reflux disease. Gastroenterol Clin North Am. 2008;37:827–43.PubMed Pandolfino J, Kwiatek M, Kahrilas P. The pathophysiologic basis for epidemiologic trends in gastroesophageal reflux disease. Gastroenterol Clin North Am. 2008;37:827–43.PubMed
Zurück zum Zitat Person E, Rife C, Freeman J, et al. Novel sleep positioning device reduces gastroesophageal reflux: a randomized controlled trial. J Clin Gastroenterol. 2015;49(8):655–9.PubMed Person E, Rife C, Freeman J, et al. Novel sleep positioning device reduces gastroesophageal reflux: a randomized controlled trial. J Clin Gastroenterol. 2015;49(8):655–9.PubMed
Zurück zum Zitat Savarino E, Marabotto E, Zentilin P, et al. The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease. Dig Liver Dis. 2011;43(7):542–7.PubMed Savarino E, Marabotto E, Zentilin P, et al. The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease. Dig Liver Dis. 2011;43(7):542–7.PubMed
Zurück zum Zitat Sifrim D, Zerbib F. Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors. Gut. 2012;61:1340–54.PubMed Sifrim D, Zerbib F. Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors. Gut. 2012;61:1340–54.PubMed
Zurück zum Zitat Subramanian C, Triadafilopoulos G. Refractory gastro-esophageal reflux disease. Gastroenterol Rep. 2015;3(1):41–53. Subramanian C, Triadafilopoulos G. Refractory gastro-esophageal reflux disease. Gastroenterol Rep. 2015;3(1):41–53.
Zurück zum Zitat Sun Y, Zhu S, Ma S, Deng Y. TCM syndrome analysis of 260 cases of GERD. Jiangsu J Tradit Chin Med. 2004;25:12. Sun Y, Zhu S, Ma S, Deng Y. TCM syndrome analysis of 260 cases of GERD. Jiangsu J Tradit Chin Med. 2004;25:12.
Zurück zum Zitat Tang X, Li B, Feng Y. Correlation analysis between quality of life and reflux related symptoms, syndrome of in-coordination between liver and stomach of patients with gastroesophageal reflux disease. Global Tradit Chin Med. 2011;4:1. Tang X, Li B, Feng Y. Correlation analysis between quality of life and reflux related symptoms, syndrome of in-coordination between liver and stomach of patients with gastroesophageal reflux disease. Global Tradit Chin Med. 2011;4:1.
Zurück zum Zitat Teschke R, Wolff A, Frenzel C, et al. Herbal traditional Chinese medicine and its evidence base in gastrointestinal disorders. World J Gastroenterol. 2015;21(15):4466–90.PubMedPubMedCentral Teschke R, Wolff A, Frenzel C, et al. Herbal traditional Chinese medicine and its evidence base in gastrointestinal disorders. World J Gastroenterol. 2015;21(15):4466–90.PubMedPubMedCentral
Zurück zum Zitat Thibault R, Coron E, Sebille V. Antireflux surgery for non-erosive and erosive reflux disease in community practice. Aliment Pharmacol Ther. 2006;24:621–32.PubMed Thibault R, Coron E, Sebille V. Antireflux surgery for non-erosive and erosive reflux disease in community practice. Aliment Pharmacol Ther. 2006;24:621–32.PubMed
Zurück zum Zitat Tokashiki R, Okamoto I, Funato N, Suzuki M. Rikkunshito improves globus sensation in patients with proton-pump inhibitor-refractory laryngopharyngeal reflux. World J Gastroenterol. 2013;19(31):5118–24.PubMedPubMedCentral Tokashiki R, Okamoto I, Funato N, Suzuki M. Rikkunshito improves globus sensation in patients with proton-pump inhibitor-refractory laryngopharyngeal reflux. World J Gastroenterol. 2013;19(31):5118–24.PubMedPubMedCentral
Zurück zum Zitat Tominaga K, Arakawa T. Kampo medicines for gastrointestinal tract disorders: a review of basic science and clinical evidence and their future application. J Gastroenterol. 2013;48(4):452–62.PubMedPubMedCentral Tominaga K, Arakawa T. Kampo medicines for gastrointestinal tract disorders: a review of basic science and clinical evidence and their future application. J Gastroenterol. 2013;48(4):452–62.PubMedPubMedCentral
Zurück zum Zitat Tominaga K, Iwakiri R, Fujimoto K. Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan. J Gastroenterol. 2011;47(3):284–92.PubMed Tominaga K, Iwakiri R, Fujimoto K. Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan. J Gastroenterol. 2011;47(3):284–92.PubMed
Zurück zum Zitat Tominaga K, Kato M, Takeda H, et al. A randomized, placebo-controlled, double-blind clinical trial of rikkunshito for patients with non-erosive reflux disease refractory to proton-pump inhibitor: the G‑PRIDE study. J Gastroenterol. 2014;49(10):1392–405.PubMed Tominaga K, Kato M, Takeda H, et al. A randomized, placebo-controlled, double-blind clinical trial of rikkunshito for patients with non-erosive reflux disease refractory to proton-pump inhibitor: the G‑PRIDE study. J Gastroenterol. 2014;49(10):1392–405.PubMed
Zurück zum Zitat Tutuian R. Adverse effects of drugs on the esophagus. Best Pract Res Clin Gastroenterol. 2010;24(2):91–7.PubMed Tutuian R. Adverse effects of drugs on the esophagus. Best Pract Res Clin Gastroenterol. 2010;24(2):91–7.PubMed
Zurück zum Zitat Vakil N, van Zanten S, Kahrilas P, et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101(8):1900–20.PubMed Vakil N, van Zanten S, Kahrilas P, et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101(8):1900–20.PubMed
Zurück zum Zitat Venables T, Newland R, Patel A, et al. Omeprazole 10 milligrams once daily, omeprazole 20 milligrams once daily, or ranitidine 150 milligrams twice daily, evaluated as initial therapy for the relief of symptoms of gastro-oesophageal reflux disease in general practice. Scand J Gastroenterol. 1997;32(10):965–73.PubMed Venables T, Newland R, Patel A, et al. Omeprazole 10 milligrams once daily, omeprazole 20 milligrams once daily, or ranitidine 150 milligrams twice daily, evaluated as initial therapy for the relief of symptoms of gastro-oesophageal reflux disease in general practice. Scand J Gastroenterol. 1997;32(10):965–73.PubMed
Zurück zum Zitat Wang H, Ma S, Zhu S‑I. Effect of Shugan He wei decoction on the LES calcuim channel mechanism of rabbits. Lishizhen Med Mater Med Res. 2013;24:5. Wang H, Ma S, Zhu S‑I. Effect of Shugan He wei decoction on the LES calcuim channel mechanism of rabbits. Lishizhen Med Mater Med Res. 2013;24:5.
Zurück zum Zitat Wilder-Smith C, Röhss K, Bokel S, et al. The effects of dose and timing of esomeprazole administration on 24‑h, daytime and night-time acid inhibition in healthy volunteers. Aliment Pharmacol Ther. 2010;32:1249–56.PubMed Wilder-Smith C, Röhss K, Bokel S, et al. The effects of dose and timing of esomeprazole administration on 24‑h, daytime and night-time acid inhibition in healthy volunteers. Aliment Pharmacol Ther. 2010;32:1249–56.PubMed
Zurück zum Zitat Wu J, Mui L, Cheung C. Obesity is associated with increased transient lower esophageal sphincter relaxation. Gastroenterology. 2007;132:883–9.PubMed Wu J, Mui L, Cheung C. Obesity is associated with increased transient lower esophageal sphincter relaxation. Gastroenterology. 2007;132:883–9.PubMed
Zurück zum Zitat Yanai M, Mochiki E, Ogawa A, et al. Intragastric administration of rikkunshito stimulates upper gastrointestinal motility and gastric emptying in conscious dogs. J Gastroenterol. 2013;48(5):611–9.PubMed Yanai M, Mochiki E, Ogawa A, et al. Intragastric administration of rikkunshito stimulates upper gastrointestinal motility and gastric emptying in conscious dogs. J Gastroenterol. 2013;48(5):611–9.PubMed
Zurück zum Zitat Zhang X, Cheng Y, Zhang Y, Zhu S‑I. Effect of Shugan Hewei Decoction central mechanism in nonerosive gastroesophageal reflux disease. Acta Univ Tradit Med Sinensis Pharmacol Shanghai. 2012;26:4. Zhang X, Cheng Y, Zhang Y, Zhu S‑I. Effect of Shugan Hewei Decoction central mechanism in nonerosive gastroesophageal reflux disease. Acta Univ Tradit Med Sinensis Pharmacol Shanghai. 2012;26:4.
Zurück zum Zitat Zhang X, Zhu S, Cheng Y. Effects of Shugan Hewei Decoction on non-erosive gastroesophageal reflux disease with anxiety and depression. Chin Arch Tradit Chin Med. 2014;32:9. Zhang X, Zhu S, Cheng Y. Effects of Shugan Hewei Decoction on non-erosive gastroesophageal reflux disease with anxiety and depression. Chin Arch Tradit Chin Med. 2014;32:9.
Zurück zum Zitat Zhao Y, Liu Z, Li L, et al. Systematic review of randomized controlled trials of traditional Chinese medicine treatment of non-acute bronchial asthma complicated by Gastroesophageal reflux. J Tradit Chin Med. 2012;32(1):12–8.PubMed Zhao Y, Liu Z, Li L, et al. Systematic review of randomized controlled trials of traditional Chinese medicine treatment of non-acute bronchial asthma complicated by Gastroesophageal reflux. J Tradit Chin Med. 2012;32(1):12–8.PubMed
Zurück zum Zitat Zhou A, Duan G, Li Z, et al. Relationship between psychological factor and TCM syndrome types of gastroesophageal reflux disease. J Luzou Med Coll. 2006;29:4. Zhou A, Duan G, Li Z, et al. Relationship between psychological factor and TCM syndrome types of gastroesophageal reflux disease. J Luzou Med Coll. 2006;29:4.
Zurück zum Zitat Zhu J, Guo Y, Liu S, et al. Acupuncture for the treatment of gastro-oesophageal reflux disease: a systematic review and meta-analysis. Acupunct Med. 2017;35(5):316–23.PubMed Zhu J, Guo Y, Liu S, et al. Acupuncture for the treatment of gastro-oesophageal reflux disease: a systematic review and meta-analysis. Acupunct Med. 2017;35(5):316–23.PubMed
Zurück zum Zitat Zhu S‑L, Sun Y, Ma S, Wang X. Multianalysis of Chinese medical syndromes of gastroesophageal regurgitation. Shanghai J Tradit Chin Med. 2006;40:10. Zhu S‑L, Sun Y, Ma S, Wang X. Multianalysis of Chinese medical syndromes of gastroesophageal regurgitation. Shanghai J Tradit Chin Med. 2006;40:10.
Metadaten
Titel
Gastroösophageale Refluxerkrankung (GERD) aus Sicht der westlichen Medizin und aus der Perspektive der Traditionellen Chinesischen Medizin (TCM)
verfasst von
Ute Giuliani
Publikationsdatum
18.07.2023
Verlag
Springer Medizin
Erschienen in
Chinesische Medizin / Chinese Medicine / Ausgabe 2/2023
Print ISSN: 0930-2786
Elektronische ISSN: 2196-5668
DOI
https://doi.org/10.1007/s00052-023-00090-8

Weitere Artikel der Ausgabe 2/2023

Chinesische Medizin / Chinese Medicine 2/2023 Zur Ausgabe

Meldungen aus der SMS

Neuer Vorstand der SMS

Kurs- und Kongressvorschau für die Schweiz

Kurse der Schweizerischen Ärztegesellschaft

Magen-Darm-Erkrankungen in der Hausarztpraxis

Häufige gastrointestinale Krankheiten in der niedergelassenen Praxis sind Thema in diesem aufgezeichneten MMW-Webinar. Welche Differenzialdiagnosen bei Oberbauchbeschwerden sollten Sie kennen? Wie gelingt eine erfolgreiche probiotische Behandlung bei Reizdarm? Welche neuen Entwicklungen und praktischen Aspekte gibt es bei Diagnostik und Behandlung der chronisch entzündlichen Darmerkrankungen?