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01.12.2012 | Review | Ausgabe 1/2012 Open Access

Cancer Cell International 1/2012

TRAIL and vitamins: opting for keys to castle of cancer proteome instead of open sesame

Cancer Cell International > Ausgabe 1/2012
Ammad Ahmad Farooqi, Shahzad Bhatti, Muhammad Ismail
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Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2867-12-22) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

All authors contributed equally to the development of the ideas and the writing of this review. All authors read and approved the final manuscript.


Cancer is a multifaceted molecular disorder that is modulated by a combination of genetic, metabolic and signal transduction aberrations, which severely impair the normal homeostasis of cell growth and death. Accumulating findings highlight the fact that different genetic alterations, such as mutations in tumor suppressor genes, might be related to distinct and differential sensitivity to targeted therapies. It is becoming increasingly apparent that a multipronged approach that addresses genetic milieu (alterations in upstream and/or parallel pathways) eventually determines the response of individual tumors to therapy. Cancerous cells often acquire the ability to evade death by attenuating cell death pathways that normally function to eliminate damaged and harmful cells. Therefore impaired cell death nanomachinery and withdrawal of death receptors from cell surface are some of major determinants for the development of chemotherapeutic resistance encountered during treatment. It is therefore essential to emphasize underlying factors which predispose cells to refractoriness against TRAIL mediated cell death pathway and the relevant regulatory components involved. We bring to limelight the strategies to re-sensitize TRAIL resistant cells via vitamins to induce apoptosis.
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