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06.04.2018 | Original Paper | Ausgabe 10/2018

AIDS and Behavior 10/2018

Trajectories of Depressive Symptoms Among a Population of HIV-Infected Men and Women in Routine HIV Care in the United States

AIDS and Behavior > Ausgabe 10/2018
Angela M. Bengtson, Brian W. Pence, Kimberly A. Powers, Mark A. Weaver, Matthew J. Mimiaga, Bradley N. Gaynes, Conall O’Cleirigh, Katerina Christopoulos, W. Christopher Mathews, Heidi Crane, Michael Mugavero
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s10461-018-2109-2) contains supplementary material, which is available to authorized users.
Presentation A version of this work was presented at the 50th Society for Epidemiological Research (SER) Meeting June 21–23, 2017 in Seattle, Washington.


Depressive symptoms vary in severity and chronicity. We used group-based trajectory models to describe trajectories of depressive symptoms (measured using the Patient Health Questionnaire-9) and predictors of trajectory group membership among 1493 HIV-infected men (84%) and 292 HIV-infected women (16%). At baseline, 29% of women and 26% of men had depressive symptoms. Over a median of 30 months of follow-up, we identified four depressive symptom trajectories for women (labeled “low” [experienced by 56% of women], “mild/moderate” [24%], “improving” [14%], and “severe” [6%]) and five for men (“low” [61%], “mild/moderate” [14%], “rebounding” [5%], “improving” [13%], and “severe” [7%]). Baseline antidepressant prescription, panic symptoms, and prior mental health diagnoses were associated with more severe or dynamic depressive symptom trajectories. Nearly a quarter of participants experienced some depressive symptoms, highlighting the need for improved depression management. Addressing more severe or dynamic depressive symptom trajectories may require interventions that additionally address mental health comorbidities.

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