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Erschienen in: European Radiology 1/2019

20.06.2018 | Vascular-Interventional

Transcatheter arterial embolisation for acute lower gastrointestinal haemorrhage: a single-centre study

verfasst von: Joon Ho Kwon, Man-Deuk Kim, Kichang Han, Woosun Choi, Yong Seek Kim, Junhyung Lee, Gyoung Min Kim, Jong Yun Won, Do Yun Lee

Erschienen in: European Radiology | Ausgabe 1/2019

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Abstract

Objective

To investigate the safety and efficacy of transcatheter arterial embolisation (TAE) in the management of lower gastrointestinal bleeding (LGIB) and to identify predictors of clinical outcomes.

Methods

Between December 2005 and April 2017, 274 patients underwent diagnostic angiography for signs and symptoms of LGIB; 134 patients with positive angiographic findings were retrospectively analysed. The technical success of TAE and clinical outcomes, including recurrent bleeding, major complications, and in-hospital mortality were evaluated. The associations of various clinical and technical factors with clinical outcomes were analysed. Predictors for clinical outcomes were evaluated using univariate and multivariate logistic regression analyses.

Results

A total of 134 patients (mean age, 59.7 years; range, 14–82 years) underwent TAE for LGIB. The bleeding foci were in the small bowel in 74 patients (55.2%), colon in 35 (26.1%), and rectum in 25 (18.7%). Technical success was achieved in 127 patients (94.8%). The clinical success rate was 63% (80/127). The rates of recurrent bleeding, major complications, and in-hospital mortality were 27.9% (31/111), 18.5% (23/124), and 23.6% (33/127), respectively. Superselective embolisation and the use of N-butyl cyanoacrylate (NBCA) were significant prognostic factors associated with reduced recurrent bleeding (OR, 0.258; p = 0.004 for superselective embolisation, OR, 0.313; p = 0.01 for NBCA) and fewer major complications (OR, 0.087; p ˂ 0.001 for superselective embolisation, OR, 0.272; p = 0.007 for NBCA).

Conclusions

TAE is an effective treatment modality for LGIB. Superselective embolisation is essential to reduce recurrent bleeding and avoid major complications. NBCA appears to be a preferred embolic agent.

Key Points

• Transcatheter arterial Embolisation (TAE) is a safe and effective treatment for lower gastrointestinal tract haemorrhage.
• Superselective embolisation is essential to improve outcomes.
• N-butyl cyanoacrylate (NBCA) appears to be a preferred embolic agent with better clinical outcomes.
Literatur
1.
Zurück zum Zitat Longstreth GF (1997) Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study. Am J Gastroenterol 92:419–424PubMed Longstreth GF (1997) Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study. Am J Gastroenterol 92:419–424PubMed
2.
Zurück zum Zitat Abbas SM, Bissett IP, Holden A, Woodfield JC, Parry BR, Duncan D (2005) Clinical variables associated with positive angiographic localization of lower gastrointestinal bleeding. ANZ J Surg 75:953–957CrossRef Abbas SM, Bissett IP, Holden A, Woodfield JC, Parry BR, Duncan D (2005) Clinical variables associated with positive angiographic localization of lower gastrointestinal bleeding. ANZ J Surg 75:953–957CrossRef
3.
Zurück zum Zitat Maleux G, Roeflaer F, Heye S et al (2009) Long-term outcome of transcatheter embolotherapy for acute lower gastrointestinal hemorrhage. Am J Gastroenterol 104:2042–2046CrossRef Maleux G, Roeflaer F, Heye S et al (2009) Long-term outcome of transcatheter embolotherapy for acute lower gastrointestinal hemorrhage. Am J Gastroenterol 104:2042–2046CrossRef
4.
Zurück zum Zitat Barnert J, Messmann H (2009) Diagnosis and management of lower gastrointestinal bleeding. Nat Rev Gastroenterol Hepatol 6:637–646CrossRef Barnert J, Messmann H (2009) Diagnosis and management of lower gastrointestinal bleeding. Nat Rev Gastroenterol Hepatol 6:637–646CrossRef
5.
Zurück zum Zitat Defreyne L, Vanlangenhove P, De Vos M et al (2001) Embolisation as a first approach with endoscopically unmanageable acute nonvariceal gastrointestinal hemorrhage. Radiology 218:739–748CrossRef Defreyne L, Vanlangenhove P, De Vos M et al (2001) Embolisation as a first approach with endoscopically unmanageable acute nonvariceal gastrointestinal hemorrhage. Radiology 218:739–748CrossRef
6.
Zurück zum Zitat Kuo WT, Lee DE, Saad WE, Patel N, Sahler LG, Waldman DL (2003) Superselective microcoil embolisation for the treatment of lower gastrointestinal hemorrhage. J Vasc Interv Radiol 14:1503–1509CrossRef Kuo WT, Lee DE, Saad WE, Patel N, Sahler LG, Waldman DL (2003) Superselective microcoil embolisation for the treatment of lower gastrointestinal hemorrhage. J Vasc Interv Radiol 14:1503–1509CrossRef
7.
Zurück zum Zitat Urbano J, Manuel Cabrera J, Franco A, Alonso-Burgos A (2014) Selective arterial embolisation with ethylene-vinyl alcohol copolymer for control of massive lower gastrointestinal bleeding: feasibility and initial experience. J Vasc Interv Radiol 25:839–846CrossRef Urbano J, Manuel Cabrera J, Franco A, Alonso-Burgos A (2014) Selective arterial embolisation with ethylene-vinyl alcohol copolymer for control of massive lower gastrointestinal bleeding: feasibility and initial experience. J Vasc Interv Radiol 25:839–846CrossRef
8.
Zurück zum Zitat Kickuth R, Rattunde H, Gschossmann J, Inderbitzin D, Ludwig K, Triller J (2008) Acute lower gastrointestinal hemorrhage: minimally invasive management with microcatheter embolisation. J Vasc Interv Radiol 19:1289–1296.e1282CrossRef Kickuth R, Rattunde H, Gschossmann J, Inderbitzin D, Ludwig K, Triller J (2008) Acute lower gastrointestinal hemorrhage: minimally invasive management with microcatheter embolisation. J Vasc Interv Radiol 19:1289–1296.e1282CrossRef
9.
Zurück zum Zitat Jae HJ, Chung JW, Kim HC et al (2008) Experimental study on acute ischaemic small bowel changes induced by superselective embolisation of superior mesenteric artery branches with N-butyl cyanoacrylate. J Vasc Interv Radiol 19:755–763CrossRef Jae HJ, Chung JW, Kim HC et al (2008) Experimental study on acute ischaemic small bowel changes induced by superselective embolisation of superior mesenteric artery branches with N-butyl cyanoacrylate. J Vasc Interv Radiol 19:755–763CrossRef
10.
Zurück zum Zitat Ikoma A, Kawai N, Sato M et al (2010) Ischaemic effects of transcatheter arterial embolisation with N-butyl cyanoacrylate-lipiodol on the colon in a Swine model. Cardiovasc Intervent Radiol 33:1009–1015CrossRef Ikoma A, Kawai N, Sato M et al (2010) Ischaemic effects of transcatheter arterial embolisation with N-butyl cyanoacrylate-lipiodol on the colon in a Swine model. Cardiovasc Intervent Radiol 33:1009–1015CrossRef
11.
Zurück zum Zitat Kodani M, Yata S, Ohuchi Y, Ihaya T, Kaminou T, Ogawa T (2016) Safety and Risk of Superselective Transcatheter Arterial Embolisation for Acute Lower Gastrointestinal Hemorrhage with N-Butyl Cyanoacrylate: Angiographic and Colonoscopic Evaluation. J Vasc Interv Radiol 27:824–830CrossRef Kodani M, Yata S, Ohuchi Y, Ihaya T, Kaminou T, Ogawa T (2016) Safety and Risk of Superselective Transcatheter Arterial Embolisation for Acute Lower Gastrointestinal Hemorrhage with N-Butyl Cyanoacrylate: Angiographic and Colonoscopic Evaluation. J Vasc Interv Radiol 27:824–830CrossRef
12.
Zurück zum Zitat O'Connor SD, Taylor AJ, Williams EC, Winter TC (2009) Coagulation concepts update. AJR Am J Roentgenol 193:1656–1664CrossRef O'Connor SD, Taylor AJ, Williams EC, Winter TC (2009) Coagulation concepts update. AJR Am J Roentgenol 193:1656–1664CrossRef
13.
Zurück zum Zitat Patel IJ, Davidson JC, Nikolic B et al (2012) Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image-guided interventions. J Vasc Interv Radiol 23:727–736CrossRef Patel IJ, Davidson JC, Nikolic B et al (2012) Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image-guided interventions. J Vasc Interv Radiol 23:727–736CrossRef
14.
Zurück zum Zitat Angle JF, Siddiqi NH, Wallace MJ et al (2010) Quality improvement guidelines for percutaneous transcatheter embolisation: Society of Interventional Radiology Standards of Practice Committee. J Vasc Interv Radiol 21:1479–1486CrossRef Angle JF, Siddiqi NH, Wallace MJ et al (2010) Quality improvement guidelines for percutaneous transcatheter embolisation: Society of Interventional Radiology Standards of Practice Committee. J Vasc Interv Radiol 21:1479–1486CrossRef
15.
Zurück zum Zitat Wiesner W, Khurana B, Ji H, Ros PR (2003) CT of acute bowel ischaemia. Radiology 226:635–650CrossRef Wiesner W, Khurana B, Ji H, Ros PR (2003) CT of acute bowel ischaemia. Radiology 226:635–650CrossRef
16.
Zurück zum Zitat Huang CC, Lee CW, Hsiao JK et al (2011) N-butyl cyanoacrylate embolisation as the primary treatment of acute hemodynamically unstable lower gastrointestinal hemorrhage. J Vasc Interv Radiol 22:1594–1599CrossRef Huang CC, Lee CW, Hsiao JK et al (2011) N-butyl cyanoacrylate embolisation as the primary treatment of acute hemodynamically unstable lower gastrointestinal hemorrhage. J Vasc Interv Radiol 22:1594–1599CrossRef
17.
Zurück zum Zitat Koh DC, Luchtefeld MA, Kim DG et al (2009) Efficacy of transarterial embolisation as definitive treatment in lower gastrointestinal bleeding. Colorectal Dis 11:53–59CrossRef Koh DC, Luchtefeld MA, Kim DG et al (2009) Efficacy of transarterial embolisation as definitive treatment in lower gastrointestinal bleeding. Colorectal Dis 11:53–59CrossRef
18.
Zurück zum Zitat Tan KK, Wong D, Sim R (2008) Superselective embolisation for lower gastrointestinal hemorrhage: an institutional review over 7 years. World J Surg 32:2707–2715CrossRef Tan KK, Wong D, Sim R (2008) Superselective embolisation for lower gastrointestinal hemorrhage: an institutional review over 7 years. World J Surg 32:2707–2715CrossRef
19.
Zurück zum Zitat Kwak HS, Han YM, Lee ST (2009) The clinical outcomes of transcatheter microcoil embolisation in patients with active lower gastrointestinal bleeding in the small bowel. Korean J Radiol 10:391–397CrossRef Kwak HS, Han YM, Lee ST (2009) The clinical outcomes of transcatheter microcoil embolisation in patients with active lower gastrointestinal bleeding in the small bowel. Korean J Radiol 10:391–397CrossRef
20.
Zurück zum Zitat Gillespie CJ, Sutherland AD, Mossop PJ, Woods RJ, Keck JO, Heriot AG (2010) Mesenteric embolisation for lower gastrointestinal bleeding. Dis Colon Rectum 53:1258–1264CrossRef Gillespie CJ, Sutherland AD, Mossop PJ, Woods RJ, Keck JO, Heriot AG (2010) Mesenteric embolisation for lower gastrointestinal bleeding. Dis Colon Rectum 53:1258–1264CrossRef
21.
Zurück zum Zitat Lipof T, Sardella WV, Bartus CM, Johnson KH, Vignati PV, Cohen JL (2008) The efficacy and durability of super-selective embolisation in the treatment of lower gastrointestinal bleeding. Dis Colon Rectum 51:301–305CrossRef Lipof T, Sardella WV, Bartus CM, Johnson KH, Vignati PV, Cohen JL (2008) The efficacy and durability of super-selective embolisation in the treatment of lower gastrointestinal bleeding. Dis Colon Rectum 51:301–305CrossRef
22.
Zurück zum Zitat Sheth R, Someshwar V, Warawdekar G (2006) Treatment of acute lower gastrointestinal hemorrhage by superselective transcatheter embolisation. Indian J Gastroenterol 25:290–294PubMed Sheth R, Someshwar V, Warawdekar G (2006) Treatment of acute lower gastrointestinal hemorrhage by superselective transcatheter embolisation. Indian J Gastroenterol 25:290–294PubMed
23.
Zurück zum Zitat d’Othee BJ, Surapaneni P, Rabkin D, Nasser I, Clouse M (2006) Microcoil embolisation for acute lower gastrointestinal bleeding. Cardiovasc Intervent Radiol 29:49–58CrossRef d’Othee BJ, Surapaneni P, Rabkin D, Nasser I, Clouse M (2006) Microcoil embolisation for acute lower gastrointestinal bleeding. Cardiovasc Intervent Radiol 29:49–58CrossRef
24.
Zurück zum Zitat Hur S, Jae HJ, Lee M, Kim HC, Chung JW (2014) Safety and efficacy of transcatheter arterial embolisation for lower gastrointestinal bleeding: a single-centre experience with 112 patients. J Vasc Interv Radiol 25:10–19CrossRef Hur S, Jae HJ, Lee M, Kim HC, Chung JW (2014) Safety and efficacy of transcatheter arterial embolisation for lower gastrointestinal bleeding: a single-centre experience with 112 patients. J Vasc Interv Radiol 25:10–19CrossRef
25.
Zurück zum Zitat Kim PH, Tsauo J, Shin JH, Yun SC (2017) Transcatheter Arterial Embolisation of Gastrointestinal Bleeding with N-Butyl Cyanoacrylate: A Systematic Review and Meta-Analysis of Safety and Efficacy. J Vasc Interv Radiol 28:522–531.e525CrossRef Kim PH, Tsauo J, Shin JH, Yun SC (2017) Transcatheter Arterial Embolisation of Gastrointestinal Bleeding with N-Butyl Cyanoacrylate: A Systematic Review and Meta-Analysis of Safety and Efficacy. J Vasc Interv Radiol 28:522–531.e525CrossRef
26.
Zurück zum Zitat Frodsham A, Berkmen T, Ananian C, Fung A (2009) Initial experience using N-butyl cyanoacrylate for embolisation of lower gastrointestinal hemorrhage. J Vasc Interv Radiol 20:1312–1319CrossRef Frodsham A, Berkmen T, Ananian C, Fung A (2009) Initial experience using N-butyl cyanoacrylate for embolisation of lower gastrointestinal hemorrhage. J Vasc Interv Radiol 20:1312–1319CrossRef
27.
Zurück zum Zitat Yata S, Ihaya T, Kaminou T et al (2013) Transcatheter arterial embolisation of acute arterial bleeding in the upper and lower gastrointestinal tract with N-butyl-2-cyanoacrylate. J Vasc Interv Radiol 24:422–431CrossRef Yata S, Ihaya T, Kaminou T et al (2013) Transcatheter arterial embolisation of acute arterial bleeding in the upper and lower gastrointestinal tract with N-butyl-2-cyanoacrylate. J Vasc Interv Radiol 24:422–431CrossRef
28.
Zurück zum Zitat Vaidya S, Tozer KR, Chen J (2008) An overview of embolic agents. Semin Interv Radiol 25:204–215CrossRef Vaidya S, Tozer KR, Chen J (2008) An overview of embolic agents. Semin Interv Radiol 25:204–215CrossRef
29.
Zurück zum Zitat Loffroy R, Guiu B, D'Athis P et al (2009) Arterial embolotherapy for endoscopically unmanageable acute gastroduodenal hemorrhage: predictors of early rebleeding. Clin Gastroenterol Hepatol 7:515–523CrossRef Loffroy R, Guiu B, D'Athis P et al (2009) Arterial embolotherapy for endoscopically unmanageable acute gastroduodenal hemorrhage: predictors of early rebleeding. Clin Gastroenterol Hepatol 7:515–523CrossRef
30.
Zurück zum Zitat Aina R, Oliva VL, Therasse E et al (2001) Arterial embolotherapy for upper gastrointestinal hemorrhage: outcome assessment. J Vasc Interv Radiol 12:195–200CrossRef Aina R, Oliva VL, Therasse E et al (2001) Arterial embolotherapy for upper gastrointestinal hemorrhage: outcome assessment. J Vasc Interv Radiol 12:195–200CrossRef
31.
Zurück zum Zitat Yonemitsu T, Kawai N, Sato M et al (2009) Evaluation of transcatheter arterial embolisation with gelatin sponge particles, microcoils, and n-butyl cyanoacrylate for acute arterial bleeding in a coagulopathic condition. J Vasc Interv Radiol 20:1176–1187CrossRef Yonemitsu T, Kawai N, Sato M et al (2009) Evaluation of transcatheter arterial embolisation with gelatin sponge particles, microcoils, and n-butyl cyanoacrylate for acute arterial bleeding in a coagulopathic condition. J Vasc Interv Radiol 20:1176–1187CrossRef
32.
Zurück zum Zitat Hongsakul K, Pakdeejit S, Tanutit P (2014) Outcome and predictive factors of successful transarterial embolisation for the treatment of acute gastrointestinal hemorrhage. Acta Radiol 55:186–194CrossRef Hongsakul K, Pakdeejit S, Tanutit P (2014) Outcome and predictive factors of successful transarterial embolisation for the treatment of acute gastrointestinal hemorrhage. Acta Radiol 55:186–194CrossRef
33.
Zurück zum Zitat Schenker MP, Duszak R Jr, Soulen MC et al (2001) Upper gastrointestinal hemorrhage and transcatheter embolotherapy: clinical and technical factors impacting success and survival. J Vasc Interv Radiol 12:1263–1271CrossRef Schenker MP, Duszak R Jr, Soulen MC et al (2001) Upper gastrointestinal hemorrhage and transcatheter embolotherapy: clinical and technical factors impacting success and survival. J Vasc Interv Radiol 12:1263–1271CrossRef
34.
Zurück zum Zitat Encarnacion CE, Kadir S, Beam CA, Payne CS (1992) Gastrointestinal bleeding: treatment with gastrointestinal arterial embolisation. Radiology 183:505–508CrossRef Encarnacion CE, Kadir S, Beam CA, Payne CS (1992) Gastrointestinal bleeding: treatment with gastrointestinal arterial embolisation. Radiology 183:505–508CrossRef
35.
Zurück zum Zitat Koo HJ, Shin JH, Kim HJ et al (2015) Clinical outcome of transcatheter arterial embolisation with N-butyl-2-cyanoacrylate for control of acute gastrointestinal tract bleeding. AJR Am J Roentgenol 204:662–668CrossRef Koo HJ, Shin JH, Kim HJ et al (2015) Clinical outcome of transcatheter arterial embolisation with N-butyl-2-cyanoacrylate for control of acute gastrointestinal tract bleeding. AJR Am J Roentgenol 204:662–668CrossRef
36.
Zurück zum Zitat Loffroy R, Rao P, Ota S, De Lin M, Kwak BK, Geschwind JF (2010) Embolisation of acute nonvariceal upper gastrointestinal hemorrhage resistant to endoscopic treatment: results and predictors of recurrent bleeding. Cardiovasc Intervent Radiol 33:1088–1100CrossRef Loffroy R, Rao P, Ota S, De Lin M, Kwak BK, Geschwind JF (2010) Embolisation of acute nonvariceal upper gastrointestinal hemorrhage resistant to endoscopic treatment: results and predictors of recurrent bleeding. Cardiovasc Intervent Radiol 33:1088–1100CrossRef
37.
Zurück zum Zitat Dempsey DT, Burke DR, Reilly RS, McLean GK, Rosato EF (1990) Angiography in poor-risk patients with massive nonvariceal upper gastrointestinal bleeding. Am J Surg 159:282–286CrossRef Dempsey DT, Burke DR, Reilly RS, McLean GK, Rosato EF (1990) Angiography in poor-risk patients with massive nonvariceal upper gastrointestinal bleeding. Am J Surg 159:282–286CrossRef
38.
Zurück zum Zitat Larson G, Schmidt T, Gott J, Bond S, O'Connor CA, Richardson JD (1986) Upper gastrointestinal bleeding: predictors of outcome. Surgery 100:765–773PubMed Larson G, Schmidt T, Gott J, Bond S, O'Connor CA, Richardson JD (1986) Upper gastrointestinal bleeding: predictors of outcome. Surgery 100:765–773PubMed
39.
Zurück zum Zitat Choudari CP, Rajgopal C, Elton RA, Palmer KR (1994) Failures of endoscopic therapy for bleeding peptic ulcer: an analysis of risk factors. Am J Gastroenterol 89:1968–1972PubMed Choudari CP, Rajgopal C, Elton RA, Palmer KR (1994) Failures of endoscopic therapy for bleeding peptic ulcer: an analysis of risk factors. Am J Gastroenterol 89:1968–1972PubMed
Metadaten
Titel
Transcatheter arterial embolisation for acute lower gastrointestinal haemorrhage: a single-centre study
verfasst von
Joon Ho Kwon
Man-Deuk Kim
Kichang Han
Woosun Choi
Yong Seek Kim
Junhyung Lee
Gyoung Min Kim
Jong Yun Won
Do Yun Lee
Publikationsdatum
20.06.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 1/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-018-5587-8

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