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Erschienen in: CardioVascular and Interventional Radiology 2/2017

03.11.2016 | Clinical Investigation

Transcatheter Arterial Embolization for Primary Postpartum Hemorrhage: Predictive Factors of Need for Embolic Material Conversion of Gelatin Sponge Particles to N-Butyl Cyanoacrylate

verfasst von: Yukichi Tanahashi, Satoshi Goshima, Hiroshi Kondo, Tomohiro Ando, Yoshifumi Noda, Hiroshi Kawada, Nobuyuki Kawai, Junichi Kotoku, Shigeru Furui, Masayuki Matsuo

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 2/2017

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Abstract

Purpose

To identify predictive factors for embolic material conversion to N-butyl cyanoacrylate (NBCA) for the treatment of primary postpartum hemorrhage (PPH) after failed transcatheter arterial embolization (TAE) using gelatin sponge (GS).

Materials and Methods

Institutional review board approval was obtained. We retrospectively studied 62 consecutive women with primary PPH who underwent TAE between January 2006 and March 2015. Five of them were excluded for the following: cardiopulmonary arrest at arrival (n = 1), uterine inversion (n = 1), and hysterectomy after TAE (n = 3). Remaining 57 women (age range, 21–43 years; mean, 32.6 years) comprised study population. TAE was initially performed using GS in all cases and then converted to NBCA after two embolizations using GS with persistent hemodynamic instability or vaginal bleeding. The patients’ background, uterine height, vital signs, laboratory tests, disseminated intravascular coagulation score, and details of procedure were reviewed. Univariate and multivariate analyses were performed to determine factors related to embolic material conversion.

Results

Technical success rate was 100%. Fourteen patients (25%) needed embolic material conversion to NBCA. Univariate analysis showed that uterine height, systolic blood pressure (sBP), and hemoglobin level were significantly related to embolic material conversion to NBCA (P = 0.029, 0.030, and 0.042). Logistic regression analysis showed that uterine height (odds ratio, 1.37; P = 0.025) and sBP (odds ratio, 0.96; P = 0.003) were associated with embolic material conversion to NBCA.

Conclusion

Uterine height and sBP can be predictive factors for embolic material conversion to NBCA for the treatment of PPH.

Level of Evidence

Level 4, Case Control Study
Literatur
2.
3.
Zurück zum Zitat Hong TM, Tseng HS, Lee RC, Wang JH, Chang CY. Uterine artery embolization: an effective treatment for intractable obstetric haemorrhage. Clin Radiol. 2004;59(1):96–101.CrossRefPubMed Hong TM, Tseng HS, Lee RC, Wang JH, Chang CY. Uterine artery embolization: an effective treatment for intractable obstetric haemorrhage. Clin Radiol. 2004;59(1):96–101.CrossRefPubMed
5.
Zurück zum Zitat Lee HY, Shin JH, Kim J, Yoon HK, Ko GY, Won HS, et al. Primary postpartum hemorrhage: outcome of pelvic arterial embolization in 251 patients at a single institution. Radiology. 2012;264(3):903–9. doi:10.1148/radiol.12111383.CrossRefPubMed Lee HY, Shin JH, Kim J, Yoon HK, Ko GY, Won HS, et al. Primary postpartum hemorrhage: outcome of pelvic arterial embolization in 251 patients at a single institution. Radiology. 2012;264(3):903–9. doi:10.​1148/​radiol.​12111383.CrossRefPubMed
6.
Zurück zum Zitat Deux JF, Bazot M, Le Blanche AF, Tassart M, Khalil A, Berkane N, et al. Is selective embolization of uterine arteries a safe alternative to hysterectomy in patients with postpartum hemorrhage? AJR Am J Roentgenol. 2001;177(1):145–9. doi:10.2214/ajr.177.1.1770145.CrossRefPubMed Deux JF, Bazot M, Le Blanche AF, Tassart M, Khalil A, Berkane N, et al. Is selective embolization of uterine arteries a safe alternative to hysterectomy in patients with postpartum hemorrhage? AJR Am J Roentgenol. 2001;177(1):145–9. doi:10.​2214/​ajr.​177.​1.​1770145.CrossRefPubMed
7.
Zurück zum Zitat Dohan A, Soyer P, Subhani A, Hequet D, Fargeaudou Y, Morel O, et al. Postpartum hemorrhage resulting from pelvic pseudoaneurysm: a retrospective analysis of 588 consecutive cases treated by arterial embolization. Cardiovasc Interv Radiol. 2013;36(5):1247–55. doi:10.1007/s00270-013-0668-1.CrossRef Dohan A, Soyer P, Subhani A, Hequet D, Fargeaudou Y, Morel O, et al. Postpartum hemorrhage resulting from pelvic pseudoaneurysm: a retrospective analysis of 588 consecutive cases treated by arterial embolization. Cardiovasc Interv Radiol. 2013;36(5):1247–55. doi:10.​1007/​s00270-013-0668-1.CrossRef
9.
Zurück zum Zitat Kim GM, Yoon CJ, Seong NJ, Kang SG, Kim YJ. Postpartum haemorrhage from ruptured pseudoaneurysm: efficacy of transcatheter arterial embolisation using N-butyl-2-cyanoacrylate. Eur Radiol. 2013;23(8):2344–9. doi:10.1007/s00330-013-2830-1.CrossRefPubMed Kim GM, Yoon CJ, Seong NJ, Kang SG, Kim YJ. Postpartum haemorrhage from ruptured pseudoaneurysm: efficacy of transcatheter arterial embolisation using N-butyl-2-cyanoacrylate. Eur Radiol. 2013;23(8):2344–9. doi:10.​1007/​s00330-013-2830-1.CrossRefPubMed
10.
Zurück zum Zitat Park KJ, Shin JH, Yoon HK, Gwon DI, Ko GY, Sung KB. Postpartum hemorrhage from extravasation or pseudoaneurysm: efficacy of transcatheter arterial embolization using N-butyl cyanoacrylate and comparison with gelatin sponge particle. J Vasc Interv Radiol. 2015;26(2):154–61. doi:10.1016/j.jvir.2014.10.001.CrossRefPubMed Park KJ, Shin JH, Yoon HK, Gwon DI, Ko GY, Sung KB. Postpartum hemorrhage from extravasation or pseudoaneurysm: efficacy of transcatheter arterial embolization using N-butyl cyanoacrylate and comparison with gelatin sponge particle. J Vasc Interv Radiol. 2015;26(2):154–61. doi:10.​1016/​j.​jvir.​2014.​10.​001.CrossRefPubMed
11.
Zurück zum Zitat Kanematsu M, Watanabe H, Kondo H, Goshima S, Kato H, Furui T, et al. Postpartum hemorrhage in coagulopathic patients: preliminary experience with uterine arterial embolization with N-butyl cyanoacrylate. J Vasc Interv Radiol. 2011;22(12):1773–6. doi:10.1016/j.jvir.2011.08.016.CrossRefPubMed Kanematsu M, Watanabe H, Kondo H, Goshima S, Kato H, Furui T, et al. Postpartum hemorrhage in coagulopathic patients: preliminary experience with uterine arterial embolization with N-butyl cyanoacrylate. J Vasc Interv Radiol. 2011;22(12):1773–6. doi:10.​1016/​j.​jvir.​2011.​08.​016.CrossRefPubMed
12.
Zurück zum Zitat ATLS Subcommittee, American College of Surgeons’ Committee on Trauma, International ATLS working group. Advanced trauma life support (ATLS®): the ninth edition. J Trauma Acute Care Surg. 2013;74(5):1363–13639. doi:10.1097/TA.0b013e31828b82f5. ATLS Subcommittee, American College of Surgeons’ Committee on Trauma, International ATLS working group. Advanced trauma life support (ATLS®): the ninth edition. J Trauma Acute Care Surg. 2013;74(5):1363–13639. doi:10.​1097/​TA.​0b013e31828b82f5​.
13.
Zurück zum Zitat Takeuchi Y, Morishita H, Sato Y, Hamaguchi S, Sakamoto N, Tokue H, et al. Guidelines for the use of NBCA in vascular embolization devised by the Committee of Practice Guidelines of the Japanese Society of Interventional Radiology (CGJSIR), 2012 edition. Jpn J Radiol. 2014;32(8):500–17. doi:10.1007/s11604-014-0328-7.CrossRefPubMed Takeuchi Y, Morishita H, Sato Y, Hamaguchi S, Sakamoto N, Tokue H, et al. Guidelines for the use of NBCA in vascular embolization devised by the Committee of Practice Guidelines of the Japanese Society of Interventional Radiology (CGJSIR), 2012 edition. Jpn J Radiol. 2014;32(8):500–17. doi:10.​1007/​s11604-014-0328-7.CrossRefPubMed
14.
Zurück zum Zitat Stoesslein F, Ditscherlein G, Romaniuk PA. Experimental studies on new liquid embolization mixtures (histoacryl-lipiodol, histoacryl-panthopaque). Cardiovasc Interv Radiol. 1982;5(5):264–7.CrossRef Stoesslein F, Ditscherlein G, Romaniuk PA. Experimental studies on new liquid embolization mixtures (histoacryl-lipiodol, histoacryl-panthopaque). Cardiovasc Interv Radiol. 1982;5(5):264–7.CrossRef
15.
Zurück zum Zitat Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M, Scientific Subcommittee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemotasis. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86(5):1327–30.PubMed Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M, Scientific Subcommittee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemotasis. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86(5):1327–30.PubMed
16.
Zurück zum Zitat Wada H, Thachil J, Di Nisio M, Mathew P, Kurosawa S, Gando S, et al. Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines. J Thromb Haemost. 2013. doi:10.1111/jth.12155. Wada H, Thachil J, Di Nisio M, Mathew P, Kurosawa S, Gando S, et al. Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines. J Thromb Haemost. 2013. doi:10.​1111/​jth.​12155.
18.
Zurück zum Zitat Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175–91.CrossRefPubMed Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175–91.CrossRefPubMed
20.
Zurück zum Zitat Brown BJ, Heaston DK, Poulson AM, Gabert HA, Mineau DE, Miller FJ Jr. Uncontrollable postpartum bleeding: a new approach to hemostasis through angiographic arterial embolization. Obstet Gynecol. 1979;54(3):361–5.PubMed Brown BJ, Heaston DK, Poulson AM, Gabert HA, Mineau DE, Miller FJ Jr. Uncontrollable postpartum bleeding: a new approach to hemostasis through angiographic arterial embolization. Obstet Gynecol. 1979;54(3):361–5.PubMed
21.
Zurück zum Zitat Ratnam LA, Gibson M, Sandhu C, Torrie P, Chandraharan E, Belli AM. Transcatheter pelvic arterial embolisation for control of obstetric and gynaecological haemorrhage. J Obstet Gynaecol. 2008;28(6):573–9. doi:10.1080/01443610802273374.CrossRefPubMed Ratnam LA, Gibson M, Sandhu C, Torrie P, Chandraharan E, Belli AM. Transcatheter pelvic arterial embolisation for control of obstetric and gynaecological haemorrhage. J Obstet Gynaecol. 2008;28(6):573–9. doi:10.​1080/​0144361080227337​4.CrossRefPubMed
22.
Zurück zum Zitat Fargeaudou Y, Soyer P, Morel O, Sirol M, le Dref O, Boudiaf M, et al. Severe primary postpartum hemorrhage due to genital tract laceration after operative vaginal delivery: successful treatment with transcatheter arterial embolization. Eur Radiol. 2009;19(9):2197–203. doi:10.1007/s00330-009-1413-7.CrossRefPubMed Fargeaudou Y, Soyer P, Morel O, Sirol M, le Dref O, Boudiaf M, et al. Severe primary postpartum hemorrhage due to genital tract laceration after operative vaginal delivery: successful treatment with transcatheter arterial embolization. Eur Radiol. 2009;19(9):2197–203. doi:10.​1007/​s00330-009-1413-7.CrossRefPubMed
26.
Zurück zum Zitat Soyer P, Dohan A, Dautry R, Guerrache Y, Ricbourg A, Gayat E, et al. Transcatheter arterial embolization for postpartum hemorrhage: indications, technique, results, and complications. Cardiovasc Interv Radiol. 2015;38(5):1068–81. doi:10.1007/s00270-015-1054-y.CrossRef Soyer P, Dohan A, Dautry R, Guerrache Y, Ricbourg A, Gayat E, et al. Transcatheter arterial embolization for postpartum hemorrhage: indications, technique, results, and complications. Cardiovasc Interv Radiol. 2015;38(5):1068–81. doi:10.​1007/​s00270-015-1054-y.CrossRef
28.
Zurück zum Zitat Lee NK, Kim S, Kim CW, Lee JW, Jeon UB, Suh DS. Identification of bleeding sites in patients with postpartum hemorrhage: MDCT compared with angiography. AJR Am J Roentgenol. 2010;194(2):383–90. doi:10.2214/AJR.09.3073.CrossRefPubMed Lee NK, Kim S, Kim CW, Lee JW, Jeon UB, Suh DS. Identification of bleeding sites in patients with postpartum hemorrhage: MDCT compared with angiography. AJR Am J Roentgenol. 2010;194(2):383–90. doi:10.​2214/​AJR.​09.​3073.CrossRefPubMed
31.
Zurück zum Zitat Yonemitsu T, Kawai N, Sato M, Sonomura T, Takasaka I, Nakai M, et al. Comparison of hemostatic durability between N-butyl cyanoacrylate and gelatin sponge particles in transcatheter arterial embolization for acute arterial hemorrhage in a coagulopathic condition in a swine model. Cardiovasc Interv Radiol. 2010;33(6):1192–7. doi:10.1007/s00270-010-9863-5.CrossRef Yonemitsu T, Kawai N, Sato M, Sonomura T, Takasaka I, Nakai M, et al. Comparison of hemostatic durability between N-butyl cyanoacrylate and gelatin sponge particles in transcatheter arterial embolization for acute arterial hemorrhage in a coagulopathic condition in a swine model. Cardiovasc Interv Radiol. 2010;33(6):1192–7. doi:10.​1007/​s00270-010-9863-5.CrossRef
32.
Zurück zum Zitat Yonemitsu T, Kawai N, Sato M, Tanihata H, Takasaka I, Nakai M, et al. Evaluation of transcatheter arterial embolization with gelatin sponge particles, microcoils, and n-butyl cyanoacrylate for acute arterial bleeding in a coagulopathic condition. J Vasc Interv Radiol. 2009;20(9):1176–87. doi:10.1016/j.jvir.2009.06.005.CrossRefPubMed Yonemitsu T, Kawai N, Sato M, Tanihata H, Takasaka I, Nakai M, et al. Evaluation of transcatheter arterial embolization with gelatin sponge particles, microcoils, and n-butyl cyanoacrylate for acute arterial bleeding in a coagulopathic condition. J Vasc Interv Radiol. 2009;20(9):1176–87. doi:10.​1016/​j.​jvir.​2009.​06.​005.CrossRefPubMed
Metadaten
Titel
Transcatheter Arterial Embolization for Primary Postpartum Hemorrhage: Predictive Factors of Need for Embolic Material Conversion of Gelatin Sponge Particles to N-Butyl Cyanoacrylate
verfasst von
Yukichi Tanahashi
Satoshi Goshima
Hiroshi Kondo
Tomohiro Ando
Yoshifumi Noda
Hiroshi Kawada
Nobuyuki Kawai
Junichi Kotoku
Shigeru Furui
Masayuki Matsuo
Publikationsdatum
03.11.2016
Verlag
Springer US
Erschienen in
CardioVascular and Interventional Radiology / Ausgabe 2/2017
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-016-1496-x

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