Erschienen in:
01.12.2013 | Case Report
Transformation of a giant cell tumor of bone into a secondary malignant fibrous histiocytoma
verfasst von:
J. Bruns, O. Yazigee, G. Delling, W. Fiedler, C. H. Lohmann, W. Rüther
Erschienen in:
European Orthopaedics and Traumatology
|
Ausgabe 4/2013
Einloggen, um Zugang zu erhalten
Excerpt
Spontaneous malignant transformation of giant cell tumor (GCT) of the bone is not uncommon [
6,
7,
9‐
11,
29]. Malignant transformation has been defined by many authors as a sarcoma associated with a benign typical GCT at presentation or as a sarcoma arising at the site of a preexisting GCT [
6,
11] resulting in osteosarcoma, fibrosarcoma, or malignant histiocytoma [
5,
31]. Many authors have reported a strong association between preventive radiation therapy in the treatment of GCT and secondary malignant transformation of the GCT [
6,
8,
11,
23,
28,
37] and/or after several local recurrences of GCT [
15,
18,
19]. However, malignant transformation without association to radiation therapy has also been reported [
5,
8]. We report a case of GCT with transformation into a secondary malignant fibrous histiocytoma that developed after local GCT recurrence and had no association to adjuvant radiation therapy. …